Berberine promotes immunological outcomes and decreases neuroinflammation in the experimental model of multiple sclerosis through the expansion of Treg and Th2 cells [0.03%]
番红花素通过促进Treg和Th2细胞增殖改善多发性硬化小鼠模型的免疫学指标及神经炎症反应
Maryam J Tavaf,Azita Soltanmohammadi,Simin Zargarani et al.
Maryam J Tavaf et al.
Introduction: Among the most frequent demyelinating autoimmune disorders of the central nervous system (CNS) is multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is used as an animal model of multiple sc...
Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis [0.03%]
LINC01138敲低通过调节hsa-miR-1207-5P/KIAA0101轴来保护人软骨细胞不受IL-1β诱导的损害
Jiangtao Zhang,Genbing Lv
Jiangtao Zhang
Introduction: Long intergenic non-protein coding RNA 1138 (LINC01138) plays a vital role in human cancers. In this study, we aimed to investigate the effect of LINC01138 on the progression of osteoarthritis (OA) and explo...
Angiotensin converting enzyme 2 activation improves allergic rhinitis and suppresses Th2 cytokine release [0.03%]
血管紧张素转换酶2的激活可改善过敏性鼻炎并抑制Th2细胞因子释放
Xiuying Sun,Yu Xu,Jinhui Zhou
Xiuying Sun
Objective: Allergic rhinitis (AR) is primarily regulated by type I hypersensitivity, with Th2 and immunoglobulin E (IgE) playing essential roles. This study aimed to determine whether angiotensin converting enzyme (ACE)2 ...
By modulating miR-525-5p/Bax axis, LINC00659 promotes vascular endothelial cell apoptosis [0.03%]
LINC00659通过调控miR-525-5p/Bax信号轴促进血管内皮细胞凋亡
Xizheng Zhu,Beijia Chen,Hui Xu
Xizheng Zhu
Background: Deep vein thrombosis (DVT) is a vascular disease that has no effective treatment at present. Endothelial cells play a crucial role in the processes vasoconstriction, platelet activation, and blood coagulation ...
Role of signal transduction pathways in IL-1β-induced apoptosis: Pathological and therapeutic aspects [0.03%]
信号转导通路在IL-1β诱导的细胞凋亡中的作用：病理和治疗方面
Peixuan Wang,Hong Qian,Manxue Xiao et al.
Peixuan Wang et al.
Background: Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of...
Analysis of risk factors of fungal superinfections in viral pneumonia patients: A systematic review and meta-analysis [0.03%]
病毒性肺炎患者真菌超级感染的风险因素分析：系统评价和-meta-分析
Haiyang Ni,Hongying Yu,Qibin Lin et al.
Haiyang Ni et al.
Background: Infections with fungi, such as Aspergillus species, have been found as common complications of viral pneumonia. This study aims to determine the risk factors of fungal superinfections in viral pneumonia patien...
4-1BB and cytokines trigger human NK, γδ T, and CD8+ T cell proliferation and activation, but are not required for their effector functions [0.03%]
4-1bb和细胞因子触发人类NK、γδT和CD8⁺T增殖和活化，但不是其效应功能的必要条件
Laurent Vidard
Laurent Vidard
Introduction: This study was designed to compare the costimulatory molecules and cytokines required to trigger the proliferation and activation of natural killer (NK), γδ T, and CD8+ T cells, and gain in-depth insight i...
Emerging roles of circRNAs in leukemia and the clinical prospects: An update [0.03%]
环状RNA在白血病中的新兴作用及其临床前景：最新研究进展
Wei Deng,Rong Chao,Shengdong Zhu
Wei Deng
Background: Circular RNAs (circRNAs) are a new category of endogenous non-protein coding RNAs (ncRNAs), and show the characteristics of high conservation, stability, and tissue specificity. Due to rapid advances in next-g...
Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells [0.03%]
补体C1q通过启动子纤维母细胞和血管平滑肌细胞的C1q球状头部受体启动外源凝血
Christopher T Freda,Wei Yin,Berhane Ghebrehiwet et al.
Christopher T Freda et al.
Background: Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more ef...
The correlation of Th22 and regulatory T cells with Helicobacter pylori infection in patients with chronic gastritis [0.03%]
Th22和调节性T细胞与慢性胃炎患者幽门螺杆菌感染的相关性研究
Biyu Yao,Xiaoyan Xu,Weijie Liu et al.
Biyu Yao et al.
Objective: Helicobacter pylori is planted in the human stomach and is the most common cause of chronic gastritis, which produced specific local and systemic humoral immunity, while the associations of these immune respons...