Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly [0.03%]
一氧化氮对IL-33和TSLP的表达具有清除ROS的作用机制
Min-Jie Gong,Hai-Bao Zhang,Miao Lou et al.
Min-Jie Gong et al.
Background: Chronic rhinosinusitis (CRS) is a chronic mucosal inflammation of the nasal cavity and sinuses. It is classified into CRS without nasal polyps and CRS with nasal polyps (CRSwNP). CRSwNP has high recurrence, es...
Syringin exerts anti-inflammatory and antioxidant effects by regulating SIRT1 signaling in rat and cell models of acute myocardial infarction [0.03%]
.syringin通过调节急性心肌梗死大鼠和细胞模型中的sirtuin 1信号发挥抗炎和抗氧化作用
Di Zhao,Ketong Liu,Jian Wang et al.
Di Zhao et al.
Introduction: This study aimed to investigate the role of syringin in improving heart function during myocardial ischemia/reperfusion (I/R) and to determine whether the sirtuin 1/peroxisome proliferator-activated receptor...
Viral load of SARS-CoV-2 Omicron BA.5 is lower than that of BA.2 despite the higher infectivity of BA.5 [0.03%]
尽管BA.5的感染性更强，但其病毒载量低于BA.2
Yuna Takatsuki,Yuta Takahashi,Jun Nakajima et al.
Yuna Takatsuki et al.
Background: Sublineage BA.5 of the SARS-CoV-2 Omicron variant rapidly spread and replaced BA.2 in July 2022 in Tokyo. A high viral load can be a possible cause of high transmissibility. ...
Toxoplasma gondii, HBV, and HCV co-infection and their correlation with CD4 cells among Iranian HIV-positive patients [0.03%]
伊朗HIV阳性患者中托拉菌属宫腔支、HBV和HCV的合并感染及其与CD4细胞的相关性
Ahmadreza Bazmjoo,Mohammad Aref Bagherzadeh,Rahim Raoofi et al.
Ahmadreza Bazmjoo et al.
Introduction: Human immunodeficiency virus (HIV/AIDS) infected patients have a higher risk of opportunistic infections (OIs) depending on their immunological status, especially CD4 + cell count. Toxoplasma gondii, hepatit...
Comparative study of clinical symptoms of chronic rhinosinusitis with nasal polyps patients [0.03%]
慢性鼻窦炎伴鼻息肉患者的临床症状比较研究
Jingmin Hu,Le Wang,Ruixia Ma
Jingmin Hu
Aim: The aim of this study is to explore the clinical characteristics in chronic rhinosinusitis with nasal polyps (CRSwNP) patients with different serum specific IgE (SIgE) and eosinophilic granulocyte infiltration status...
Observational Study
Immunity, inflammation and disease. 2023 Feb;11(2):e773. DOI:10.1002/iid3.773 2023
Role of Th17 cells, Treg cells, and Th17/Treg imbalance in immune homeostasis disorders in patients with chronic obstructive pulmonary disease [0.03%]
TH17细胞、Treg细胞及失衡在慢性阻塞性肺疾病患者免疫稳态失调中的作用
Ru Ma,Hongling Su,Keping Jiao et al.
Ru Ma et al.
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, following strokes and cardiovascular diseases. Chronic lung inflammation is believed to play a role in the development of COPD. In addition, accumul...
Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage [0.03%]
SENP3丢失通过增加鼻黏膜炎症中过度活化巨噬细胞的形成来介导鼻息肉形成
Ximing Bao,Bin Liu,Yongquan Jiang et al.
Ximing Bao et al.
Background and aim: Small ubiquitin-like modifier (SUMO)-specific protease (SENP)3 is a protease molecule that responds to reactive oxygen species (ROS) with high sensitivity. However, the role of ROS and SENP3 in the for...
Gallic acid regulates immune response in a mouse model of rheumatoid arthritis [0.03%]
没食子酸通过调节小鼠类风湿关节炎模型中的免疫反应发挥抗炎作用
Siqin Liu,Jiajia Li,Le-Heng Feng
Siqin Liu
Introduction: Previous studies revealed that gallic acid (GA) exerts anti-inflammation and immuno-regulatory properties. This study aims to explore the pharmacological activities of GA in collagen-induced arthritis (CIA) ...
Are monoclonal antibodies effective in patients with severe obesity in SARS-CoV-2 infected? [0.03%]
严重肥胖的SARS-CoV-2感染患者单克隆抗体有效吗？
Claudio Ucciferri,Livia Moffa,Samanta Moffa et al.
Claudio Ucciferri et al.
It is important to block SARS-CoV-2 infection immediately with early therapies, such as monoclonal antibodies (MonoAbs). Also, several studies show that obesity is associated with a high risk of severe COVID-19 disease. We enrolled 32 SARS-...
Reduced probability of improving viro-immunological state in subjects with vertical transmission of HIV reaching adult age: A multicenter retrospective cohort study [0.03%]
有关垂直感染HIV并进入成人期的患者改善病毒-免疫状态可能性降低：一项基于多中心回顾性队列的研究
Francesca Pennati,Stefano Calza,Antonio Di Biagio et al.
Francesca Pennati et al.
Introduction: Young adults with vertical transmission (VT) of human immunodeficiency virus (HIV) represent a fragile population. This study evaluates factors associated with viro-immunological outcome of these patients. ...
Multicenter Study
Immunity, inflammation and disease. 2023 Feb;11(2):e778. DOI:10.1002/iid3.778 2023