Respiratory Syncytial Virus and COVID-19 in Hospitalized Adults in Spain: Clinical, Radiological Features and Antimicrobial Use [0.03%]
西班牙住院成人呼吸道合胞病毒和新冠肺炎的临床、放射学特征及抗菌药物使用情况
Jose-Reynaldo Homen Fernandez,Inés Armenteros,Adrián Valls Carbó et al.
Jose-Reynaldo Homen Fernandez et al.
Background: Lower respiratory tract infections (LRTIs) impose a significant global burden, with over 400 million cases annually. This study compares the clinical features of adults hospitalized with respiratory syncytial ...
The Unprecedented Influenza Epidemic of 2024/2025: Overshadowing the COVID-19 Winter Wave and Exploring Viral Interference [0.03%]
2024/2025年空前的流感大流行：掩盖COVID-19冬季浪潮并探索病毒干扰效应
Benjamin Davido
Benjamin Davido
Background: In winter 2024/2025, one of the most severe U.S. influenza epidemics since 2017, with 82 million illnesses and ~ 130,000 deaths, eclipsed a comparatively subdued SARS-CoV-2 wave (~ 20 million infections, ~540,...
Neutrophil Extracellular Traps Activate Meningeal Fibroblast to Aggravate Subarachnoid Fibrosis in Kaolin-Induced Hydrocephalus in Rats [0.03%]
中性粒细胞胞外诱捕网激活蛛网膜下腔成纤维细胞加重可乐定诱导的脑室内出血模型SD大鼠脑积水_subarachnoid fibroblast
Chao Ma,Zhou Feng,Binyuan Xiong et al.
Chao Ma et al.
Background and objectives: Subarachnoid fibrosis is the key pathology of hydrocephalus, but its underlying mechanisms remains poorly understood. In the present study, we aim to verify the hypothesis that neutrophil extrac...
The Imbalanced Patterns and Clinical Significance of Cytokines in Acute Myeloid Leukemia Microenvironment [0.03%]
急性髓系白血病微环境细胞因子不平衡模式及临床意义
Rong Wang,Keying Jing,Huijuan Zhao et al.
Rong Wang et al.
Introduction: Acute myeloid leukemia (AML) is known for its unfavorable prognosis, prompting research efforts of cytokines in the microenvironment to explore new therapeutic targets. Here, we investigated the complex cyto...
Chimeric Antigen Receptor T-Cell Therapy and Autoimmune Diseases in the Nervous System [0.03%]
嵌合抗原受体T细胞治疗与神经系统自身免疫疾病
Shun-Yu Yao,Miao-Qiao Du,Huan Yang et al.
Shun-Yu Yao et al.
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy, a revolutionary immunotherapy originally developed for hematologic malignancies, has recently gained attention for its potential in treating autoimmune disea...
Research Progress of Annexin A1 and Its Derived Peptides in the Diagnosis and Treatment of Circulatory Diseases [0.03%]
annexin a1及其衍生肽在循环系统疾病诊断与治疗中研究进展
Qiuyu Dai,Jie Zheng,Meng Fu et al.
Qiuyu Dai et al.
Background: Annexin A1 (ANXA1), a calcium-dependent phospholipid-binding protein, plays a critical role in regulating inflammation, apoptosis, immune responses, and vascular remodeling. It is increasingly recognized for i...
Clonorchis sinensis Crude Antigen Suppresses Osteoclast Differentiation via Modulation of the NF-κB and MAPK Signaling Pathway [0.03%]
姜片吸虫线虫抗原抑制破骨细胞分化通过调节NF-κB和MAPK信号通路实现
Lili Tang,Shanshan He,Buguo Ma et al.
Lili Tang et al.
Background: Clonorchis sinensis crude antigen (CsCA) is recognized for its immunomodulatory capacity in host-pathogen interactions and immune-related pathologies, its direct impact on bone remodeling cells remains underex...
Tacrolimus Trough Concentration-Escalating Bipartite Therapy (Glucocorticoids Combined With Tacrolimus) for Refractory MDA5 Antibody-Positive Clinically Amyopathic Dermatomyositis With Rapidly Progressive Interstitial Pneumonia [0.03%]
难治性MDA5抗体阳性无肌炎皮炎的环孢素 trough浓度爬坡式序贯他克莫司联合糖皮质激素治疗快速进展性间质性肺炎
Anji Xiong,Jiang Shao,Yanzao Zhao et al.
Anji Xiong et al.
Objective: This study aimed to determine the outcomes of patients that have refractory anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis with rapidly progressiv...
Electroacupuncture of Guanyuan (CV4) Acupoint Improved Pelvic Inflammatory Disease Pain by Inhibiting Neuroinflammation and Sympathetic Activity [0.03%]
电针关元穴通过抑制神经炎症和交感神经活性缓解盆腔炎性疼痛
Jinyu Qu,Yingchun Peng,Xuefang Shen et al.
Jinyu Qu et al.
Objective: To investigate the underlying mechanisms through which electroacupuncture (EA) at the Guanyuan (CV4) acupoint inhibits sympathetic activity and neurogenic inflammatory responses to relieve pain in rats with pel...
Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity [0.03%]
脾脏巨噬细胞在疟疾发病机制和免疫中的作用
Aarti Gupta,Meenu Kalkal,Jyoti Das
Aarti Gupta
Background: Malaria, caused by Plasmodium parasites, remains a leading global health concern, impacting millions of people globally. Splenic macrophages are specialized immune cells that reside in the spleen and play a pi...