Functional Characterization of an IL2RG Variant, a Case Report of X-Linked T- B + NK + SCID [0.03%]
一个X连锁T-B+NK+重症联合免疫缺陷的IL2RG变异体的功能表征（病例报告）
Kristian Assing,Emil Birch Christensen,Christoffer Dellgren et al.
Kristian Assing et al.
Objectives: Pathogenic variants in IL2RG, encoding the common γ chain (γc/CD132), usually lead to T - B + NK- X-SCID but can, occasionally, generate a T - B + NK+ phenotype. We wanted to delineate potential mechanisms f...
Integration Analysis of Metabolome and Transcriptome Reveals the Effect of Lipopolysaccharide on Ovary Response to Stimulation [0.03%]
代谢组和转录组联合分析揭示脂多糖对卵巢促排卵反应的影响
Xin Mu,Feng Zhu,Yudan Zhang et al.
Xin Mu et al.
Objective: This study aimed to elucidate the underlying mechanisms by which lipopolysaccharide (LPS) influences differential ovarian responses to controlled ovarian stimulation at the metabolite and gene levels. ...
Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient-Gene-Disease Interaction [0.03%]
冬虫夏草通过“成分-基因-疾病”相互作用靶向炎症、凋亡和氧化应激来缓解慢性阻塞性肺病症状
Zirui Zang,Yuhan Kong,Qi Kong
Zirui Zang
Objective: Cordyceps sinensis (CS) is a fungus that parasitizes the larvae and corpses of Batmadaceae insects. CS is used as a traditional Chinese medicine and has shown promising clinical efficacy in the treatment of chr...
Effects on Serum Protein Levels From One Bout of High Intensity Interval Training in Individuals With Axial Spondyloarthritis and Controls [0.03%]
高强度间歇训练对轴性脊柱关节炎患者和健康对照人群血清蛋白水平的影响
Åsa Andersson,M Charlotte Olsson,Anna Torell et al.
Åsa Andersson et al.
Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing card...
Unraveling the Clinical and Molecular Landscape of Myocardial Infarction in Behçet's Syndrome: A Comprehensive Analysis [0.03%]
贝赫切特综合征心肌梗死的临床和分子特征分析：一项综合研究
Li-Yang Zhang,Chun-Hui She,Hu Dan et al.
Li-Yang Zhang et al.
Objectives: Behçet's syndrome (BS) is a rare inflammatory disorder with life-threatening complications like myocardial infarction (MI), driven by vasculitis and immune-mediated thrombosis. This study unveils distinct cli...
The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target [0.03%]
活性氧在牙周炎中作用及其作为治疗靶点的潜力
Shuyu Yang,Xi Yang
Shuyu Yang
Background: ROS are pivotal in maintaining periodontal tissue health due to their dual role in physiological and pathological states. At physiological levels, ROS are essential for host defense, effectively eliminating pa...
Immunosuppression Efficacy via Nonlinear Modeling and Probabilistic Analysis of Human Leukocyte Antigen Match and Dose Effects on Allograft Rejection Risk [0.03%]
人类白细胞抗原匹配和剂量效应的非线性建模与概率分析对异基因移植排斥风险的免疫抑制效力
Samrajya Raj Acharya,Aayush Man Regmi,Sushil Ghimire et al.
Samrajya Raj Acharya et al.
Background: Human Leukocyte Antigen (HLA) compatibility is a key driver of kidney allograft outcomes, yet how matching interacts with immunosuppressant dosing remains unclear. This study evaluates whether low-resolution H...
Identification of Potential Common Pathogenic Mechanisms Underlying Osteoarthritis and Major Depressive Disorder Using Bioinformatics Analysis [0.03%]
利用生物信息学分析识别软骨细胞中潜在的共同发病机制以应对骨关节炎和重大抑郁症
Taiyuan Guan,Peixin Li,Sijian Su et al.
Taiyuan Guan et al.
Background: Patients with osteoarthritis (OA) exhibit an elevated risk for major depressive disorder (MDD), primarily due to chronic pain and associated disability. However, the shared molecular mechanisms underlying thes...
Clinical Efficacy and Safety of BIC/TAF/FTC in Elderly HIV-Infected Individuals in Southwest China: A Retrospective Observation Study [0.03%]
中国西南地区老年HIV感染者应用 bic/taf/ftc临床疗效及安全性观察研究
Shujing Ma,Xiaoxin Xie,Yanhua Fu et al.
Shujing Ma et al.
Background: Long-term outcome data from real-world studies of the bictegravir emtricitabine tenofovir alafenamide fumarate (B/F/TAF) regimen in the treatment of elderly patients with HIV/AIDS are still limited. This study...
Observational Study
Immunity, inflammation and disease. 2025 Nov;13(11):e70264. DOI:10.1002/iid3.70264 2025