Baicalin as a Regulator of Peroxisome Proliferator-Activated Receptor Gamma: Alleviating Sepsis-Induced Liver Injury by Inhibiting the Cluster of Differentiation 14/Nuclear Factor Kappa B Signaling Pathway [0.03%]
汉防木素通过调控PPAR-γ信号通路抑制CD14/NF-κB信号途径缓解脓毒症肝损伤的作用及机制研究
Hui Wang,Mengmeng Guo,Xueling Zeng et al.
Hui Wang et al.
Background: Sepsis frequently results in multiple organ failure, with the liver particularly susceptible to sepsis-induced damage. The flavonoid baicalin (BA), derived from Scutellaria baicalensis, presents anti-inflammat...
The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs [0.03%]
补体系统在ANCA相关性血管炎中的作用：机制、治疗前景及未满足的临床需求
Kehinde Sunmboye,Pauline Millan
Kehinde Sunmboye
Background: ANCA-associated vasculitides (AAV) are autoimmune small-vessel vasculitides characterized by necrotizing inflammation with few immune deposits ("pauci-immune" lesions). Historically, complement was thought to ...
PRKACB Attenuates Chondrocyte Loss and Inflammation in Osteoarthritis [0.03%]
蛋白激酶A催化亚基PRKACB通过抑制软骨细胞丢失和滑膜炎症减轻骨关节炎病理进展
Weidan Xiao,Zhengmao Liu,Qijuan Zhang
Weidan Xiao
Background: Previous work revealed that protein kinase cAMP-dependent catalytic β (PRKACB) may play a crucial role in osteoarthritis (OA) development. However, the mechanism by which PRKACB plays a role in OA still needs...
Predictors of Intravenous Immunoglobulin Non-Responsiveness in Children With Kawasaki Disease [0.03%]
儿童川崎病静脉用丙种免疫球蛋白治疗无反应的预测因素分析
Yun Cheng,Biquan Chen
Yun Cheng
Background: This retrospective study assesses whether the systemic immune-inflammation index (SII) is a better predictor of intravenous immunoglobulin (IVIG) non-responsiveness (IVIG-NR) in children with Kawasaki disease ...
Negative Correlation Between Serum Ferritin and CD4+ Lymphocytes: A Retrospective Study on Kikuchi-Fujimoto Disease [0.03%]
血清 ferritin 与 CD4+ 淋巴细胞的负相关关系——关于 Kikuchi-Fujimoto 病的回顾性研究
Peng Zhong,Xiwen Sang,Yu Yang et al.
Peng Zhong et al.
Background: Kikuchi-Fujimoto disease (KFD) is a rare condition characterized by elevated serum ferritin levels and a robust immune response involving various lymphocyte subtypes. However, the relationship between ferritin...
GPR108 Negatively Regulates TLR7 Signaling in Imiquimod-Induced Psoriasiform Dermatitis [0.03%]
GPR108通过抑制TLR7信号转导负向调节咪喹莫德诱导的银屑病皮炎模型中的炎症反应
Wenwen Wang,Yuyan Zhang,Kainan Liao et al.
Wenwen Wang et al.
Objective: Psoriasis, a common chronic inflammatory skin disease, is characterized by epidermal hyperplasia and inflammatory cell infiltration. While endosomal Toll-like receptors (TLRs), particularly TLR7, are key driver...
Yiqi Daozhi Formula Reduces the M1 Polarization of Macrophages in Mice With Postoperative Ileus Through Mediating Glycolysis Metabolism [0.03%]
益气导滞方通过介导糖酵解代谢减少术后肠麻痹小鼠巨噬细胞M1极化
Wang Gang,Zhao Xuan,Wang Ye et al.
Wang Gang et al.
Background: Postoperative ileus (POI) represents a disorder of gastrointestinal function following surgical procedures, characterized by a multifaceted etiology. There is an urgent clinical need to search for treatment re...
Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis [0.03%]
TNFAIP3、IRAK1和TLR4基因多态性与类风湿关节炎患者关系的研究分析
Zhenboyang Tang,Lihui Peng,Zixia Zhao et al.
Zhenboyang Tang et al.
Objective: Rheumatoid arthritis (RA) arises from a complex interplay of polygenic susceptibility, epigenetic factors, and environmental modifiers. This study investigated the correlation between RA and Tumor necrosis fact...
Role of LIGHT in the Inflammatory Mechanisms of Psoriasis via Upregulation of Proliferation and Cytokine Production of Keratinocytes [0.03%]
LIGHT在银屑病炎症机制中的作用及其上调角质形成细胞增殖和细胞因子产生的作用
Cheng-Bin Ye,Cheng-Wen Fei,Ting Cao et al.
Cheng-Bin Ye et al.
Background: The pathogenesis of psoriasis is associated with abnormalities in immune pathways. HVEM is known as a receptor of LIGHT (homologous to lymphotoxins, inducible, and competes with HSV glycoprotein D), which is a...
Epidemiology of Mycoplasma genitalium Infections of the Genitourinary Tract Among Attendees of STI Clinic in Hangzhou, China [0.03%]
中国杭州一家性病门诊就诊者泌尿生殖道梅毒螺旋体感染的流行病学特征研究
Xinmin Qiu,Jiazhen Shi,Hongqin Gu et al.
Xinmin Qiu et al.
Objective: This study aimed to investigate the prevalence, associated clinical manifestations, and co-infection patterns of Mycoplasma genitalium (MG) infection among patients attending Venereal Disease, Urology, and Gyne...