Impaired Autophagic Flux in Adipose Tissue Aggravates Pancreatic Injury in Obesity-Related Severe Acute Pancreatitis [0.03%]
肥胖相关性重症急性胰腺炎患者脂肪组织自噬流受损加重胰腺损伤
Li-Ping Sheng,Guo-Chen Shang,Chao-Qun Han et al.
Li-Ping Sheng et al.
Background: Adipose tissue (AT) playing a crucial role in obesity-related pancreatitis. This study investigated the impact of autophagy in AT on pancreatic injury during obesity-related severe acute pancreatitis (SAP). ...
Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells [0.03%]
补体成分C1q与 adventitial成纤维细胞和血管平滑肌细胞上的C1q球形头部受体结合诱导的凝血酶生成
Christopher Thor Freda,Wei Yin,Berhane Ghebrehiwet et al.
Christopher Thor Freda et al.
Introduction: Heightened inflammatory and thrombotic processes are common hallmarks of vascular diseases. The interaction between these two processes remains unclear and a better understanding of these links can allow for...
Mast Cell-Derived CXCL4: A Key Mediator of Ferroptosis and Cardiac Damage in Septic Cardiomyopathy [0.03%]
组胺细胞衍生的CXCL4：脓毒症心肌病中铁死亡和心脏损伤的关键介质
Jing Wei,Zhi-Ying Jiang,Ling-Feng Ye et al.
Jing Wei et al.
Background: Septic cardiomyopathy (SCM) is a common and life-threatening complication of severe sepsis, with high mortality due to unclear underlying mechanisms. CXCL4, a key pro-inflammatory factor, is implicated in vari...
Modulation of Cytokines and Immune Cells by Plasma Exchange in Patients With Certain Autoimmune Neurological Diseases [0.03%]
血浆置换对某些自身免疫性神经疾病患者细胞因子和免疫细胞的调节作用
Wanquan Xu,Shuting Chai,Gang Liu et al.
Wanquan Xu et al.
Objective: Therapeutic plasma exchange (TPE) plays a crucial role in the management of autoimmune neurological disorders, although its effects on cytokines and immune cells are not fully understood. This study aimed to in...
Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF-κB Pathway [0.03%]
白芍素通过p38MAPK/NF-κB信号通路抑制椎间盘细胞活性达到治疗椎间盘退变的目的
Kai Yang,Yanping Cheng,Dan Yang
Kai Yang
Background: As a chronic musculoskeletal disorder, intervertebral disc degeneration (IDD) is a leading cause of low back pain. Inflammatory response plays a key role in the IDD progression. Albiflorin (AF), a bioactive co...
Glycemic Variability as a Predictor of Mortality in Sepsis Patients With Concurrent Persistent Inflammation, Immunosuppression, and Catabolism Syndrome [0.03%]
血糖波动在并存持续性炎症、免疫抑制和分解代谢综合征的脓毒症患者中作为死亡率预测因子的作用
Shuhang Wang,Li Liu,Bowen Li et al.
Shuhang Wang et al.
Background: Sepsis is a life-threatening condition caused by infection, which triggers dysregulated systemic inflammatory responses. Among sepsis patients, those who concurrently develop persistent inflammation, immunosup...
New Perspective: Bench to Bedside Evidence of the Role of CD8+ T Cells in Alzheimer's Disease [0.03%]
新视角：关于CD8+t细胞在阿尔茨海默病中的作用的证据从实验室到临床
Yong Peng,Shun-Yu Yao,Si-Liang Wu et al.
Yong Peng et al.
Introduction: Amyloid beta plaques and tau tangles are the primary hallmarks of Alzheimer's disease (AD). Recently, passive anti-Aβ immunotherapy for AD has markedly advanced, as supported by evidence from AD animal mode...
RANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway [0.03%]
Rankl通过OPG/RANKL/RANK/TLR4信号通路削弱内毒素致急性肺损伤
Xinrong Niu,Nurmaimeti Turson,Weilin Chen et al.
Xinrong Niu et al.
Background: Sepsis-associated acute lung injury (SA-ALI) is a critical disease marked by a dysregulated immune response to infection, causing organ dysfunction. ...
Main Protease From SARS-CoV-2 Dysregulates Glucose Handling in the C2C12 Cell Line In Vitro: A Mechanistic Study [0.03%]
SARS-CoV-2 主蛋白酶通过体内实验调节C2C12细胞系中葡萄糖处理：一种机制研究
Praise Tatenda Nhau,Mlindeli Gamede,Andile Khathi et al.
Praise Tatenda Nhau et al.
Background: There is evidence demonstrating the risk of developing diabetes mellitus because of SARS-CoV-2 infection. Therefore, further research is needed to determine pathological mechanisms at which SARS-CoV-2 induces ...
A Novel Autoimmune Presentation of Wiskott-Aldrich Syndrome: Type 1 Diabetes [0.03%]
Wiskott-Aldrich综合征的新型自身免疫表现：1型糖尿病
Melanie Natasha Rayan,Yara Alshawabkeh,Samad Zia et al.
Melanie Natasha Rayan et al.
Background: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency characterized by microthrombocytopenia, eczema, and recurrent infections. While autoimmune complications are common in WAS, including ...