Asperosaponin VI Alleviates Cisplatin-Induced Liver Injury Through the Nrf2/HO-1 Signaling Pathway [0.03%]
Han-Hua Li,Xiao-Ming Zhou,Chuan-Wei Sun et al.
Han-Hua Li et al.
Background: Cisplatin (Cis) chemotherapy-induced hepatotoxicity frequently leads to treatment interruption or dose reduction, ultimately compromising therapeutic outcomes. Asperosaponin VI (AVI), a bioactive triterpenoid ...
Autoimmune Phenomena and New-Onset Type 1 Diabetes Following SARS-CoV-2 Vaccination: A Personal Perspective [0.03%]
Kimihiko Sugaya
Kimihiko Sugaya
A molecular biologist whose wife suddenly developed type I diabetes in the summer of 2022 addresses the possible risk of developing autoimmune disease from messenger RNA (mRNA) vaccination against SARS-CoV-2. This essay also provides a reco...
Clinicopathologic Characterization of Muscle Biopsy Findings in Overlap Myositis: A Single Tertiary Care Center Experience [0.03%]
Sidra Fatima,Megha Uppin,Liza Rajasekhar et al.
Sidra Fatima et al.
Objective: This study aims to describe the muscle biopsy features of overlap myositis (OM) and compare them with other inflammatory myopathies. We analyzed clinical, serological findings, and histopathological patterns in...
Performance of Three Commercial Rapid Diagnostic Tests for Detection of IgM and IgG Antibodies Against SARS-CoV-2 [0.03%]
Moyra Machado Portilho,Stephane Fraga de Oliveira Tosta,Maysa Pellizzaro et al.
Moyra Machado Portilho et al.
Background: Despite widespread vaccination, SARS-CoV-2 transmission continues, and serological testing remains relevant for selected diagnostic scenarios and population-based assessments of antibody responses. Rapid diagn...
Inflammatory Biomarkers as Mediators of the Effect Between High-Dose Corticosteroid Therapy and Mortality in COVID-19-Related ARDS: A Causal Mediation Analysis [0.03%]
Katrijn Daenen,Anders Boyd,Virgil A S H Dalm et al.
Katrijn Daenen et al.
Background: Treatment guidelines for acute respiratory distress syndrome (ARDS) recommend the use of high-dose corticosteroids based on their anti-inflammatory effects, yet the efficacy of this therapeutic strategy in pat...
Inhibition of NTF4 Attenuates High Glucose-Induced Apoptosis and Inflammation in HTR-8/SVneo Cells via the PI3K/AKT Pathway [0.03%]
Li Zhang,Juan Yang
Li Zhang
Objective: This study aims to investigate the role of neurotrophin-4 (NTF4) in gestational diabetes mellitus (GDM) and to elucidate the underlying mechanism by which NTF4 regulates high glucose-induced apoptosis and infla...
The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs [0.03%]
Alireza Abdollahi,Aysan Nozheh,Kimia Mozahheb Yousefi et al.
Alireza Abdollahi et al.
Introduction: Antibiotic resistance is a critical global health issue, primarily driven by inappropriate antibiotic prescribing. Identifying reliable biomarkers to guide antibiotic use is essential to combat this challeng...
Effect of Respiratory Syncytial Virus on the Global Burden of Lower Respiratory Infections: Lessons From the Global Burden of Disease Study 1990-2021 [0.03%]
全球疾病负担研究（1990-2021）对呼吸道合胞病毒造成下呼吸道感染疾病负担的影响分析
Jiafen Zhao,Tao Zhou,Cheng Jiang et al.
Jiafen Zhao et al.
Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory infections (LRIs), especially in children, the elderly, and immunocompromised individuals. ...
Extracellular Vesicles: A Mailcoach From Mast Cell to Other Cell Species [0.03%]
细胞外囊泡：肥大细胞与其他细胞间交流的信使教练
Bingqi Zhang,Yueshan Sun,Tao Jiang et al.
Bingqi Zhang et al.
Background: Mast cells (MCs) are pivotal immune cells. Beyond soluble mediators, mast cell-derived extracellular vesicles (MC-EVs) are crucial for intercellular communication. MC-EV heterogeneity, influenced by cellular a...
Predictive Role of Serum Inflammatory Markers in Metastatic Luminal A/B Breast Cancers Receiving CDK-4/6 Inhibitors Therapy [0.03%]
循环炎症因子标志物在CDK4/6抑制剂治疗的转移性 luminalA/B型乳腺癌中预后的预测价值
Nilufer Bulut,Tanju Kapagan,Aykut Ozmen et al.
Nilufer Bulut et al.
Background: We conducted this study to evaluate the impact of serum inflammatory markers and histopathological features on prognosis in metastatic hormone receptor positive breast cancer patients treated with first line C...