Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex [0.03%]
并行机制揭示了听觉皮层中序列结构违反的层次性
Sara Jamali,Sophie Bagur,Enora Bremont et al.
Sara Jamali et al.
The brain predicts regularities in sensory inputs at multiple complexity levels, with neuronal mechanisms that remain elusive. Here, we monitored auditory cortex activity during the local-global paradigm, a protocol nesting different regula...
A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia [0.03%]
一种新型单体淀粉样蛋白β激活的信号通路通过抑制小胶质细胞调节脑发育
Hyo Jun Kwon,Devi Santhosh,Zhen Huang
Hyo Jun Kwon
Amyloid β (Aβ) forms aggregates in the Alzheimer's disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain. Whether Aβ also regulates glial physiolog...
Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions [0.03%]
人免疫缺陷病毒-1诱导宿主基因组R环结构并在R环附近优先整合其基因组
Kiwon Park,Dohoon Lee,Jiseok Jeong et al.
Kiwon Park et al.
Although HIV-1 integration sites favor active transcription units in the human genome, high-resolution analysis of individual HIV-1 integration sites has shown that the virus can integrate into a variety of host genomic locations, including...
The transformation of sensory to perceptual braille letter representations in the visually deprived brain [0.03%]
视觉剥夺对大脑中感知型盲文字母表征向感觉型盲文字母表征的转变的影响
Marleen Haupt,Monika Graumann,Santani Teng et al.
Marleen Haupt et al.
Experience-based plasticity of the human cortex mediates the influence of individual experience on cognition and behavior. The complete loss of a sensory modality is among the most extreme such experiences. Investigating such a selective, y...
Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50's ATPase activities and homologous recombination [0.03%]
酿酒酵母Rev7通过抑制Mre11核酸酶和Rad50的ATP酶活性及同源重组促进非同源末端连接作用
Sugith Badugu,Kshitiza Mohan Dhyani,Manoj Thakur et al.
Sugith Badugu et al.
Recent studies have shown that, in human cancer cells, the tetrameric Shieldin complex (comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining (NHEJ) while blocking homologous recombination (HR). Surprisingly, seve...
Cortical beta oscillations map to shared brain networks modulated by dopamine [0.03%]
皮层β振荡映射到多巴胺调制的共享脑网络中
Meera Chikermane,Liz Weerdmeester,Nanditha Rajamani et al.
Meera Chikermane et al.
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13-35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory, and emotion, but the...
Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds [0.03%]
栖息地片段化介导了长期气候驱动的鸟类暖温化的机制
Juan Liu,Morgan W Tingley,Qiang Wu et al.
Juan Liu et al.
Climatic warming can shift community composition driven by the colonization-extinction dynamics of species with different thermal preferences; but simultaneously, habitat fragmentation can mediate species' responses to warming. As this pote...
PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking [0.03%]
PDGFRα信号调节Srsf3结合mRNA以影响PI3K信号和胞内吞转运
Thomas E Forman,Marcin P Sajek,Eric D Larson et al.
Thomas E Forman et al.
Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during mouse skeletal dev...
Jian Wu,Nisha A Jonniya,Sophia P Hirakis et al.
Jian Wu et al.
Although the αC-β4 loop is a stable feature of all protein kinases, the importance of this motif as a conserved element of secondary structure, as well as its links to the hydrophobic architecture of the kinase core, has been underappreci...
Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster [0.03%]
拟南芥果蝇咽部分泌感觉神经元控制食物吞咽现象
Jierui Qin,Tingting Yang,Kexin Li et al.
Jierui Qin et al.
As the early step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the m...