Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning [0.03%]
深度突变扫描揭示了人类基因组中的最小扭结姐妹样自我切割核酶
Zhe Zhang,Xu Hong,Peng Xiong et al.
Zhe Zhang et al.
Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis of two previously proposed self-cleavi...
Emmanuel Ponsot
Emmanuel Ponsot
Damage to the synapses connecting hair cells to the auditory nerve leads to undetected hearing impairments. Keywords: ...
Editorial
eLife. 2024 Dec 5:13:e104936. DOI:10.7554/eLife.104936 2024
Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans [0.03%]
内源性过氧化氢通过神经内分泌作用正向调节小肠多肽的分泌，增强秀丽隐杆线虫对氧化压力的反应能力
Qi Jia,Drew Young,Qixin Zhang et al.
Qi Jia et al.
The gut-brain axis mediates bidirectional signaling between the intestine and the nervous system and is critical for organism-wide homeostasis. Here, we report the identification of a peptidergic endocrine circuit in which bidirectional sig...
Suying Liu,Sarah E Adams,Haotian Zheng et al.
Suying Liu et al.
Hematopoietic dysfunction has been associated with a reduction in the number of active precursors. However, precursor quantification at homeostasis and under diseased conditions is constrained by the scarcity of available methods. To addres...
A conserved cell-pole determinant organizes proper polar flagellum formation [0.03%]
一个保守的细胞极决定因子能正确组织周质极鞭毛的形成
Erick E Arroyo-Pérez,John C Hook,Alejandra Alvarado et al.
Erick E Arroyo-Pérez et al.
The coordination of cell cycle progression and flagellar synthesis is a complex process in motile bacteria. In γ-proteobacteria, the localization of the flagellum to the cell pole is mediated by the SRP-type GTPase FlhF. However, the mecha...
Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus [0.03%]
胎儿和成人胸腺中T细胞受体(TCR)基因片段使用及主要组织相容性复合体(MHC)限制性的差异
Jasmine Rowell,Ching-In Lau,Susan Ross et al.
Jasmine Rowell et al.
Here, we sequenced rearranged TCRβ and TCRα chain sequences in CD4+CD8+ double positive (DP), CD4+CD8- single positive (SP4) and CD4-CD8+ (SP8) thymocyte populations from the foetus and young adult mouse. We found that life-stage had a gr...
β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall [0.03%]
β-1,6-糖原在双层真菌细胞壁结构和重塑中发挥核心作用
Clara Bekirian,Isabel Valsecchi,Sophie Bachellier-Bassi et al.
Clara Bekirian et al.
The cell wall of human fungal pathogens plays critical roles as an architectural scaffold and as a target and modulator of the host immune response. Although the cell wall of the pathogenic yeast Candida albicans is intensively studied, one...
Multisensory integration enhances audiovisual responses in the Mauthner cell [0.03%]
多感觉整合增强Mauthner细胞的视听反应
Santiago Otero-Coronel,Thomas Preuss,Violeta Medan
Santiago Otero-Coronel
Multisensory integration (MSI) combines information from multiple sensory modalities to create a coherent perception of the world. In contexts where sensory information is limited or equivocal, it also allows animals to integrate individual...
Chloe Santos,Abigail R Marshall,Ailish Murray et al.
Chloe Santos et al.
Primary and secondary neurulation - processes that form the spinal cord - are incompletely understood in humans, largely due to the challenge of accessing neurulation-stage embryos (3-7 weeks post-conception). Here, we describe findings fro...
Pf MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum [0.03%]
恶性疟原虫中MORC蛋白调控染色质可及性并抑制转录
Zeinab M Chahine,Mohit Gupta,Todd Lenz et al.
Zeinab M Chahine et al.
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regulat...