Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration [0.03%]
单核转录组揭示骨再生过程中骨膜骨骼/干细胞祖细胞的分化轨迹
Simon Perrin,Maria Ethel,Vincent Bretegnier et al.
Simon Perrin et al.
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly un...
Yongjun Li,Nitin S Chouhan,Shirley L Zhang et al.
Yongjun Li et al.
Memory consolidation in Drosophila can be sleep-dependent or sleep-independent, depending on the availability of food. The anterior posterior (ap) alpha'/beta' (α'/β') neurons of the mushroom body (MB) are required for sleep-dependent mem...
Chris van Hoorn,Andrew P Carter
Chris van Hoorn
Ciliary rootlets are striated bundles of filaments that connect the base of cilia to internal cellular structures. Rootlets are critical for the sensory and motile functions of cilia. However, the mechanisms underlying these functions remai...
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration [0.03%]
弱碱性药物的质子化逆转可大大增强其细胞内扩散并减少溶酶体摄取
Debabrata Dey,Shir Marciano,Anna Poryval et al.
Debabrata Dey et al.
For drugs to be active they have to reach their targets. Within cells this requires crossing the cell membrane, and then free diffusion, distribution, and availability. Here, we explored the in-cell diffusion rates and distribution of a ser...
Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development [0.03%]
内皮素与GDNF信号在肠神经系统发育中的交叉作用具有谱系特异性
Denise M Poltavski,Alexander T Cunha,Jaime Tan et al.
Denise M Poltavski et al.
Two major ligand-receptor signaling axes - endothelin Edn3 and its receptor Ednrb, and glial-derived neurotrophic factor (GDNF) and its receptor Ret - are required for migration of enteric nervous system (ENS) progenitors to the hindgut. Mu...
Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden [0.03%]
高克隆性血液病负担的非小细胞肺癌患者髓系细胞炎症特征增强
Hyungtai Sim,Hyun Jung Park,Geun-Ho Park et al.
Hyungtai Sim et al.
Clonal hematopoiesis of indeterminate potential (CHIP) allows estimation of clonal dynamics and documentation of somatic mutations in the hematopoietic system. Recent studies utilizing large cohorts of the general population and patients ha...
Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA) [0.03%]
利用雷帕霉素诱导的邻近测定法（RiPA）识别PROTAC开发中合适的靶点/E3连接酶配对
Bikash Adhikari,Katharina Schneider,Mathias Diebold et al.
Bikash Adhikari et al.
The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized drug development. While the human genome enc...
Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction [0.03%]
一类新型ELF3-MED23互作抑制剂茋查尔酮和吡唑啉衍生物的合成与活性研究
Soo-Yeon Hwang,Kyung-Hwa Jeon,Hwa-Jong Lee et al.
Soo-Yeon Hwang et al.
HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical s...
When abstract becomes concrete, naturalistic encoding of concepts in the brain [0.03%]
当抽象成为具体——概念在大脑中的自然主义表征编码机制研究
Viktor Nikolaus Kewenig,Gabriella Vigliocco,Jeremy I Skipper
Viktor Nikolaus Kewenig
Language is acquired and processed in complex and dynamic naturalistic contexts, involving the simultaneous processing of connected speech, faces, bodies, objects, etc. How words and their associated concepts are encoded in the brain during...
Sabrina Benas,Ximena Fernandez,Emilio Kropff
Sabrina Benas
Entorhinal grid cells implement a spatial code with hexagonal periodicity, signaling the position of the animal within an environment. Grid maps of cells belonging to the same module share spacing and orientation, only differing in relative...