Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET [0.03%]
时间分辨过渡金属离子FRET揭示配体诱导环核苷酸门控离子通道的构象变化
Pierce Eggan,Sharona E Gordon,William N Zagotta
Pierce Eggan
Cyclic nucleotide-binding domain (CNBD) ion channels play crucial roles in cellular-signaling and excitability and are regulated by the direct binding of cyclic adenosine- or guanosine-monophosphate (cAMP, cGMP). However, the precise allost...
Value construction through sequential sampling explains serial dependencies in decision making [0.03%]
序贯抽样中的价值构建可以解释决策过程中的序列相关性
Ariel Zylberberg,Akram Bakkour,Daphna Shohamy et al.
Ariel Zylberberg et al.
Deciding between a pair of familiar items is thought to rely on a comparison of their subjective values. When the values are similar, decisions take longer, and the choice may be inconsistent with stated value. These regularities are though...
Semantic relatedness proactively benefits learning, memory, and interdependence across episodes [0.03%]
语义相关性有利于学习、记忆以及不同事件间的相互影响
Kelly A Bennion,Jade Phong,Mytien Le et al.
Kelly A Bennion et al.
Over the past century of memory research, the interplay between initial and later-learned information in determining long-term memory retention has been of central interest. A likely factor for determining whether initial and later memories...
Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity [0.03%]
组织驻留的自然杀伤细胞通过促进cDC1-CD8 T活性来支持胰腺癌中的生存
Simei Go,Constantinos Demetriou,Giampiero Valenzano et al.
Simei Go et al.
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate ...
A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus [0.03%]
基于空间自相关的一种新颖图像分割方法可识别丘脑中的A型钾通道簇
Csaba Dávid,Kristóf Giber,Katalin Kerti-Szigeti et al.
Csaba Dávid et al.
Unsupervised segmentation in biological and non-biological images is only partially resolved. Segmentation either requires arbitrary thresholds or large teaching datasets. Here, we propose a spatial autocorrelation method based on Local Mor...
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens [0.03%]
MYR1缺陷型刚地弓形虫突变体的旁分泌拯救揭示了池化体内CRISPR筛选的局限性
Francesca Torelli,Diogo M da Fonseca,Simon W Butterworth et al.
Francesca Torelli et al.
Toxoplasma gondii is an intracellular parasite that subverts host cell functions via secreted virulence factors. Up to 70% of parasite-controlled changes in the host transcriptome rely on the MYR1 protein, which is required for the transloc...
UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins [0.03%]
UGGT1介导的N-糖链再葡萄糖化与不稳定及错误折叠糖蛋白的内质网相关降解相互竞争
Satoshi Ninagawa,Masaki Matsuo,Deng Ying et al.
Satoshi Ninagawa et al.
How the fate (folding versus degradation) of glycoproteins is determined in the endoplasmic reticulum (ER) is an intriguing question. Monoglucosylated glycoproteins are recognized by lectin chaperones to facilitate their folding, whereas gl...
Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling [0.03%]
内源性低聚物形成可促成DVL2凝聚体并促进Wnt/β-连环蛋白信号转导
Senem Ntourmas,Martin Sachs,Petra Paclíková et al.
Senem Ntourmas et al.
Activation of the Wnt/β-catenin pathway crucially depends on the polymerization of dishevelled 2 (DVL2) into biomolecular condensates. However, given the low affinity of known DVL2 self-interaction sites and its low cellular concentration,...
Efficient value synthesis in the orbitofrontal cortex explains how loss aversion adapts to the ranges of gain and loss prospects [0.03%]
高效的价值综合在眶额皮层解释了损失厌恶如何适应收益和损失前景的范围
Jules Brochard,Jean Daunizeau
Jules Brochard
Is irrational behavior the incidental outcome of biological constraints imposed on neural information processing? In this work, we consider the paradigmatic case of gamble decisions, where gamble values integrate prospective gains and losse...
Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos [0.03%]
复杂的非整倍体触发自噬和p53介导的凋亡并损害人类植入前胚胎的第二谱系分异
Marius Regin,Yingnan Lei,Edouard Couvreu De Deckersberg et al.
Marius Regin et al.
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies in mouse embryos and human...