Nathaniel C Nelson,Matthias C Kugler
Nathaniel C Nelson
Cells called alveolar myofibroblasts, which have a central role in the development of the lung after birth, receive an orchestrated input from a range of different signaling pathways. ...
Editorial
eLife. 2024 Dec 11:13:e105095. DOI:10.7554/eLife.105095 2024
Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens [0.03%]
新型IIb型微环肽对革兰氏阴性耐药菌和植物病原菌的活性研究
Benedikt M Mortzfeld,Shakti K Bhattarai,Vanni Bucci
Benedikt M Mortzfeld
Interspecies interactions involving direct competition via bacteriocin production play a vital role in shaping ecological dynamics within microbial ecosystems. For instance, the ribosomally produced siderophore bacteriocins, known as class ...
Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification [0.03%]
肺泡简单化的病理特征是肌成纤维细胞增殖受损
Imran S Khan,Christopher Molina,Xin Ren et al.
Imran S Khan et al.
Premature infants with bronchopulmonary dysplasia (BPD) have impaired alveolar gas exchange due to alveolar simplification and dysmorphic pulmonary vasculature. Advances in clinical care have improved survival for infants with BPD, but the ...
Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals [0.03%]
癌基因中剪接和多聚腺苷酸化信号的体细胞突变反复破坏肿瘤抑制基因
Yaroslav Kainov,Fursham Hamid,Eugene V Makeyev
Yaroslav Kainov
The expression of eukaryotic genes relies on the precise 3'-terminal cleavage and polyadenylation of newly synthesized pre-mRNA transcripts. Defects in these processes have been associated with various diseases, including cancer. While canc...
Stable sequential dynamics in prefrontal cortex represents subjective estimation of time [0.03%]
前额叶皮层的稳定序贯动力学表征主观时间估算
Yiting Li,Wenqu Yin,Xin Wang et al.
Yiting Li et al.
Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified 'sequential firing' and 'activity ramps' as the primary neuron activity patterns in the medial frontal cortex (mPFC) that could...
Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint [0.03%]
酵母DNA损伤响应中的长时间细胞周期阻滞需要维持DNA损伤信号转导和纺锤体组装检验点的功能
Felix Y Zhou,David P Waterman,Marissa Ashton et al.
Felix Y Zhou et al.
Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cel...
Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution [0.03%]
单细胞分辨率下的小鼠犁鼻器的分子、细胞和发育组织学特征
Max Henry Hills,Limei Ma,Ai Fang et al.
Max Henry Hills et al.
We have generated single cell transcriptomic atlases of vomeronasal organs (VNO) from juvenile and adult mice. Combined with spatial molecular imaging, we uncover a distinct, previously unidentified class of cells that express the vomeronas...
SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire [0.03%]
SLAM/SAP信号调节不连续的γδT细胞发育检查点并塑造固有样γδTCR库
Somen K Mistri,Brianna M Hilton,Katherine J Horrigan et al.
Somen K Mistri et al.
During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developme...
Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning [0.03%]
雄性大鼠在长时间的帕沃洛夫恐惧条件反射中发出令人不快的44kHz超声波叫声
Krzysztof Hubert Olszyński,Rafał Polowy,Agnieszka Diana Wardak et al.
Krzysztof Hubert Olszyński et al.
Rats are believed to communicate their emotional state by emitting two distinct types of ultrasonic vocalizations. The first is long '22-kHz' vocalizations (>300 ms, 150 ms), generally at a constant frequency (usually within 35-50-kHz range...
Priya M Christensen,Jonathan Martin,Aparna Uppuluri et al.
Priya M Christensen et al.
Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that Streptococcus agalactiae Mpr...