Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern [0.03%]
自主细胞定时驱动脊椎动物节律钟的波动态态_pattern
Laurel A Rohde,Arianne Bercowsky-Rama,Guillaume Valentin et al.
Laurel A Rohde et al.
Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through ...
Yi Sun,Zhe Chen,Minjun Jin et al.
Yi Sun et al.
How cells regulate the size of their organelles remains a fundamental question in cell biology. Cilia, with their simple structure and surface localization, provide an ideal model for investigating organelle size control. However, most stud...
Caspar specifies primordial germ cell count and identity in Drosophila melanogaster [0.03%]
果蝇Caspar通过控制原始生殖细胞的数量和身份来影响生殖细胞的发生发育过程
Subhradip Das,Sushmitha Hegde,Neel Wagh et al.
Subhradip Das et al.
Repurposing of pleiotropic factors during execution of diverse cellular processes has emerged as a regulatory paradigm. Embryonic development in metazoans is controlled by maternal factors deposited in the egg during oogenesis. Here, we exp...
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings [0.03%]
在致肥胖环境中遗传失活锌转运蛋白SLC39A5可改善肝功能和高血糖症
Shek Man Chim,Kristen Howell,John Dronzek et al.
Shek Man Chim et al.
Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreove...
Projection neurons are necessary for the maintenance of the mouse olfactory circuit [0.03%]
projection神经元对于维持小鼠嗅觉环路的必要性
Luis Sánchez-Guardado,Peyman Razavi,Bo Wang et al.
Luis Sánchez-Guardado et al.
The assembly and maintenance of neural circuits is crucial for proper brain function. Although the assembly of brain circuits has been extensively studied, much less is understood about the mechanisms controlling their maintenance as animal...
Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum [0.03%]
主动收缩的内质网腔道输送的流体动力学
Pyae Hein Htet,Edward Avezov,Eric Lauga
Pyae Hein Htet
The endoplasmic reticulum (ER), the largest cellular compartment, harbours the machinery for the biogenesis of secretory proteins and lipids, calcium storage/mobilisation, and detoxification. It is shaped as layered membranous sheets interc...
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain [0.03%]
人胎盘组织产品作为术后止痛的非阿片类药物
Chi Zhang,Qian Huang,Neil C Ford et al.
Chi Zhang et al.
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Clar...
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances [0.03%]
雌激素通过改变离子通道电导 elicited 弧旁核 kisspeptin神经元的 发射模式distinct firing patterns
Jian Qiu,Margaritis Voliotis,Martha A Bosch et al.
Jian Qiu et al.
Hypothalamic kisspeptin (Kiss1) neurons are vital for pubertal development and reproduction. Arcuate nucleus Kiss1 (Kiss1ARH) neurons are responsible for the pulsatile release of gonadotropin-releasing hormone (GnRH). In females, the behavi...
Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes [0.03%]
单细胞转录组揭示犁鼻器神经上皮中不同感觉神经元亚型的内质网环境差异
G V S Devakinandan,Mark Terasaki,Adish Dani
G V S Devakinandan
Specialized chemosensory signals elicit innate social behaviors in individuals of several vertebrate species, a process that is mediated via the accessory olfactory system (AOS). The AOS comprising the peripheral sensory vomeronasal organ h...
Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier [0.03%]
与血脑屏障形成和维持相关的关键表观遗传及信号因素
Jayanarayanan Sadanandan,Sithara Thomas,Iny Elizabeth Mathew et al.
Jayanarayanan Sadanandan et al.
The blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (...