Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates [0.03%]
芽孢杆菌AdhE超结构的结构特征及动力学表明其对有毒中间体具有包容策略
Samantha J Ziegler,Brandon C Knott,Josephine N Gruber et al.
Samantha J Ziegler et al.
Clostridium thermocellum, a cellulolytic thermophilic anaerobe, is considered by many to be a prime candidate for the realization of consolidated bioprocessing (CBP) and is known as an industry standard for biofuel production. C. thermocell...
Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis [0.03%]
伽马刀立体定向放射治疗联合替雷利珠单抗用于pMMR/MSS/MSI-L转移性结直肠癌后线治疗的II期临床研究分析
Yiran Zhang,Hanyang Guan,Shijin Liu et al.
Yiran Zhang et al.
Background: An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges. ...
Clinical Trial
eLife. 2025 Jun 26:14:RP103559. DOI:10.7554/eLife.103559 2025
Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation [0.03%]
斑贴衍生的液-液相分离调节mRNA翻译
Abhishek Kumar,Keiichiro Tanaka,Martin A Schwartz
Abhishek Kumar
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form LLPS, which govern adhesion dynamics an...
Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin [0.03%]
不同基因型的肠炎沙门氏菌分离株在适应性和流行度上的差异性研究
Cheryll M Sia,Rebecca L Ambrose,Mary Valcanis et al.
Cheryll M Sia et al.
Salmonella Dublin is a host-adapted, invasive nontyphoidal Salmonella (iNTS) serovar that causes bloodstream infections in humans and demonstrates increasing prevalence of antimicrobial resistance (AMR). Using a global dataset of 1303 genom...
Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway [0.03%]
肌轻链3作为神经坏死病毒通过宏观胞饮途径进入宿主细胞的受体
Lan Yao,Wanwan Zhang,Xiaogang Yang et al.
Lan Yao et al.
Nodaviridae infections cause severe mortality in insects and fish, with nervous necrosis virus (NNV) posing significant threats to global fish populations. However, the host factors involved in NNV entry remain poorly understood. We identif...
Investigating working memory updating processes of the human subcortex using 7T MRI [0.03%]
利用7T磁共振研究人类纹状体工作记忆更新过程
Anne C Trutti,Zsuzsika Sjoerds,Russell J Boag et al.
Anne C Trutti et al.
A growing body of research suggests that dopamine is involved in working memory updating and that the striatum takes up a critical role in the subprocess of working memory gating . In this study, we investigated subcortical - in particular,...
Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output [0.03%]
解开小脑传出纤维损伤引起的急性运动缺陷和代偿反应
Nirvik Sinha,Sharon Israely,Ora Ben Harosh et al.
Nirvik Sinha et al.
Patients with cerebellar damage experience various motor impairments, but the specific sequence of primary and compensatory processes that contribute to these deficits remains unclear. To clarify this, we reversibly blocked cerebellar outfl...
Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas Foxg1 represses an electrosensory fate [0.03%]
Atoh1基因对于侧线电感受器和毛细胞的形成是必需的，Foxg1基因则抑制电感觉命运
Martin Minařík,Alexander S Campbell,Roman Franěk et al.
Martin Minařík et al.
In electroreceptive jawed fishes and amphibians, individual lateral line placodes form lines of neuromasts on the head containing mechanosensory hair cells, flanked by fields of ampullary organs containing electroreceptors - modified hair c...
Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement [0.03%]
组织驻留记忆CD4+t细胞通过位置特异性的自我更新和持续补充维持自身稳定
Jodie Chandler,M Elise Bullock,Arpit C Swain et al.
Jodie Chandler et al.
Tissue-resident memory T cells (TRM) protect from repeat infections within organs and barrier sites. The breadth and duration of such protection are defined at minimum by three quantities: the rate at which new TRM are generated from precur...
Martin Krause,Wolfram Schulze,Stefan Schuster
Martin Krause
It is widely accepted that more time and information yield better decisions. However, some decisions manage to be extremely fast and yet accurate. The trick of such highspeed decisions appears to be the use of simplifying heuristics that wo...