Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice [0.03%]
针对提前衰老小鼠TFAM和线粒体DNA拷贝数调节的组织特异性响应
Laura Sophie Kremer,Guanbin Gao,Giovanni Rigoni et al.
Laura Sophie Kremer et al.
Somatic mitochondrial DNA (mtDNA) mutations are implicated as important drivers of ageing and age-related diseases. Their pathological effect can be counteracted by increasing the absolute amount of wild-type mtDNA via moderately upregulati...
Sarah Hallstein,Julian König
Sarah Hallstein
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress. ...
Editorial
eLife. 2025 Jun 30:14:e107575. DOI:10.7554/eLife.107575 2025
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism [0.03%]
通过mRNA代谢被动塑造细胞内和细胞间m6A动态过程
David Dierks,Ran Shachar,Ronit Nir et al.
David Dierks et al.
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated within cells and across stimuli, and the for...
Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate [0.03%]
双特异自动磷酸化的IKK2激酶通过磷酶中间体使IκBα底物发生磷酸化
Prateeka Borar,Tapan Biswas,Ankur Chaudhuri et al.
Prateeka Borar et al.
Rapid and high-fidelity phosphorylation of serine residues at positions 32 and 36 of IκBα by IKK2/β, a highly conserved prototypical Ser/Thr kinase in vertebrates, is critical for canonical NF-κB activation. Here, we report that human I...
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues [0.03%]
用于厘米级组织纳米尺度成像的扩展辅助选择性平面照明显微镜技术
Adam Glaser,Jayaram Chandrashekar,Sonya Vasquez et al.
Adam Glaser et al.
Recent advances in tissue processing, labeling, and fluorescence microscopy are providing unprecedented views of the structure of cells and tissues at sub-diffraction resolutions and near single molecule sensitivity, driving discoveries in ...
CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration [0.03%]
CD131通过促进巨噬细胞浸润参与溃疡性结肠炎发病机制
Zhiyuan Wu,Lindi Liu,Chenchen He et al.
Zhiyuan Wu et al.
Background: Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease mainly affecting the colon. The exact etiology of UC remains elusive. CD131 is a receptor subunit mediating the effects of hematopoietic...
Marisa Mackie,Vivian Vy Le,Heather R Carstensen et al.
Marisa Mackie et al.
Animals with small nervous systems have a limited number of sensory neurons that must encode information from a changing environment. This problem is particularly exacerbated in nematodes that populate a wide variety of distinct ecological ...
Expanding automated multiconformer ligand modeling to macrocycles and fragments [0.03%]
用于大环化合物和片段的自动构象异构体配体建模扩展
Jessica Flowers,Nathaniel Echols,Galen J Correy et al.
Jessica Flowers et al.
Small molecule ligands exhibit a diverse range of conformations in solution. Upon binding to a target protein, this conformational diversity is reduced. However, ligands can retain some degree of conformational flexibility even when bound t...
Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches [0.03%]
激素操纵与雌性斑胸草雀相关发声学习的性染色体基因表达分析研究
Matthew Davenport,Ha Na Choe,Hiroaki Matsunami et al.
Matthew Davenport et al.
Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with partial atrophy and apparent repression of several vocal learning b...
Neurons throughout the brain embed robust signatures of their anatomical location into spike trains [0.03%]
大脑中的神经元将其解剖位置嵌入到动作电位中
Gemechu Bekele Tolossa,Aidan M Schneider,Eva Dyer et al.
Gemechu Bekele Tolossa et al.
Neurons in the brain are known to encode diverse information through their spiking activity, primarily reflecting external stimuli and internal states. However, whether individual neurons also embed information about their own anatomical lo...