The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast [0.03%]
分子逻辑在新生酵母中Gtr1/2和Pib2依赖的TORC1调控机制中的作用
Jacob H Cecil,Cristina M Padilla,Austin A Lipinski et al.
Jacob H Cecil et al.
The Target of Rapamycin kinase Complex 1 (TORC1) regulates cell growth and metabolism in eukaryotes. Previous studies have shown that, in Saccharomyces cerevisiae, nitrogen and amino acid signals activate TORC1 via the highly conserved smal...
Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [0.03%]
小鼠急性应激后脑内阿黑皮素原肽动态变化的高灵敏度体内检测
Marwa O Mikati,Petra Erdmann-Gilmore,Rose Connors et al.
Marwa O Mikati et al.
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity. To begin to address this, w...
The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence [0.03%]
ESCRT蛋白CHMP5通过控制内溶酶体-线粒体介导的细胞衰老限制骨形成
Fan Zhang,Yuan Wang,Luyang Zhang et al.
Fan Zhang et al.
The dysfunction of the cellular endolysosomal pathway, such as in lysosomal storage diseases, can cause severe musculoskeletal disorders. However, how endolysosomal dysfunction causes musculoskeletal abnormalities remains poorly understood,...
Fan Zhang,Hao-Ze Chen,Bo Zheng et al.
Fan Zhang et al.
Antibiotic resistance and tolerance present significant challenges in global healthcare, necessitating alternative strategies such as phage therapy. However, the rapid emergence of phage-resistant mutants poses a potential risk. Here, using...
Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma [0.03%]
磁控细胞疗法降低眼内压治疗开角型青光眼的新策略研究
M Reza Bahranifard,Jessica Chan,A Thomas Read et al.
M Reza Bahranifard et al.
Trabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excel...
The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks [0.03%]
稳态突触放缩与稳态结构可塑性的相互作用维持神经网络的稳健发放率
Han Lu,Sandra Diaz-Pier,Maximilian Lenz et al.
Han Lu et al.
Critical network states and neural plasticity enable adaptive behavior in dynamic environments, supporting efficient information processing and experience-dependent learning. Synaptic-weight-based Hebbian plasticity and homeostatic synaptic...
Cestode larvae excite host neuronal circuits via glutamatergic signalling [0.03%]
利用谷氨酸信号的小袋虫幼虫激发宿主神经电路
Anja de Lange,Hayley Tomes,Joshua S Selfe et al.
Anja de Lange et al.
Neurocysticercosis (NCC) is caused by infection of the brain by larvae of the parasitic cestode Taenia solium. It is the most prevalent parasitic infection of the central nervous system and one of the leading causes of adult-acquired epilep...
Drosophila hamlet mediates epithelial tissue assembly of the reproductive system [0.03%]
果蝇hamlet基因介导生殖系统上皮组织的组装
Huazhen Wang,Ludivine Bertonnier-Brouty,Isabella Artner et al.
Huazhen Wang et al.
Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites t...
Nicolas N Rieser,Milena Ronchetti,Adriana Lea Lea Hotz et al.
Nicolas N Rieser et al.
Galanin is a neuropeptide, which is critically involved in homeostatic processes like controlling arousal, sleep, and regulation of stress. This extensive range of functions aligns with implications of galanin in diverse pathologies, includ...
Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula [0.03%]
拟南芥根皮层中细胞间感染能力涉及从细胞周期退出的后复制型决策
Morgane Batzenschlager,Beatrice Lace,Ning Zhang et al.
Morgane Batzenschlager et al.
During root nodule symbiosis (RNS), cell-division activity is reinitiated and sustained in the root cortex to create a hospitable cellular niche. Such a temporary and spatially confined site is required to render host cells compatible with ...