Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter [0.03%]
串联模块化BK通道结构揭示LRRC26（γ1）、孔道和选择性过滤器在门控控制中的不同化学计量比
Guanxing Chen,Qin Li,Kunal Shah et al.
Guanxing Chen et al.
Big-conductance, Ca²+-activated K+ (BK) channels consist of Ca²+- and voltage-sensing, pore-forming α (BKα) subunits and regulatory auxiliary β or γ subunits. Concatenated subunit constructs are powerful tools for elucidating subunit ...
High-fidelity neural speech reconstruction through an efficient acoustic-linguistic dual-pathway framework [0.03%]
一种高效的声学-语言双通道框架实现高保真神经语音重构模型
Jiawei Li,Chunxu Guo,Chao Zhang et al.
Jiawei Li et al.
Reconstructing speech from neural recordings is crucial for understanding human speech coding and developing brain-computer interfaces (BCIs). However, existing methods trade off acoustic richness (pitch, prosody) for linguistic intelligibi...
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage [0.03%]
深度学习将机制模型与单细胞转录组数据联系起来揭示了DNA损伤反应中的转录爆发现象
Zhiwei Huang,Songhao Luo,Zihao Wang et al.
Zhiwei Huang et al.
Cells must adopt flexible regulatory strategies to make decisions regarding their fate, including differentiation, apoptosis, or survival in the face of various external stimuli. One key cellular strategy that enables these functions is sto...
Correction: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish [0.03%]
纠正：p53和mTOR/AKT对抗在斑马鱼体内促进端粒缩短从凋亡到衰老的转换
Mounir El Maï,Marta Marzullo,Inês Pimenta de Castro et al.
Mounir El Maï et al.
Published Erratum
eLife. 2026 Mar 4:15:e111193. DOI:10.7554/eLife.111193 2026
SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy [0.03%]
SLC4A1基因突变导致远端肾小管性酸中毒并改变细胞内pH值和自噬作用
Grace Essuman,Midhat Rizvi,Ensaf Almomani et al.
Grace Essuman et al.
Distal renal tubular acidosis (dRTA) is a disorder characterized by the inability of the collecting duct system to secrete acids during metabolic acidosis. The pathophysiology of dominant or recessive SLC4A1 variant-related dRTA has been li...
Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites [0.03%]
组蛋白H3赖氨酸115乙酰化修饰与CpG岛启动子及活跃调控区域的不稳固核小体相关
Yatendra Kumar,Dipta Sengupta,Elias T Friman et al.
Yatendra Kumar et al.
Acetylation of lysine residues in the tail domain of histone H3 is well characterised, but lysine residues in the histone globular domain are also acetylated. Histone modifications in the globular domain have regulatory potential because of...
N Sören Häfker
N Sören Häfker
Experiments on Drosophila show that an evolutionarily conserved photoreceptor that senses light outside of the retina can regulate responses to direct visual cues. ...
Editorial
eLife. 2026 Mar 4:15:e110807. DOI:10.7554/eLife.110807 2026
Intracellular expression of a fluorogenic DNA aptamer using retron Eco2 [0.03%]
利用Eco2回文序列在细胞内表达荧光DNA适配体
Mahesh A Vibhute,Corbin Machatzke,Saskia Krümpel et al.
Mahesh A Vibhute et al.
DNA aptamers are short, single-stranded DNA molecules that bind specifically to a range of targets such as proteins, cells, and small molecules. Typically, they are utilized in the development of therapeutic agents, diagnostics, drug delive...
Hannah H McDermott,Federico de Martino,Caspar M Schwiedrzik et al.
Hannah H McDermott et al.
The brain is thought to optimise behaviour by generating predictions based on learned statistical regularities. Predictive processing seemingly explains expectation suppression (ES), the attenuation of neural activity in response to expecte...
Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA [0.03%]
寡少弱畸形精子小鼠体内注射裸露mRNA通过电穿孔恢复精子活力
Charline Vilpreux,Paul Fourquin,Guillaume Martinez et al.
Charline Vilpreux et al.
Oligo-astheno-teratozoospermia (OAT), a recurrent cause of male infertility, is the most frequent disorder of spermatogenesis with a predominantly genetic origin. Patients and mice bearing mutations in the ARMC2 gene exhibit reduced sperm c...