NR2F2 is required in the embryonic testis for fetal Leydig cell development [0.03%]
NR2F2对胚胎期睾丸原条性勒狄格细胞发育是必需的
Aitana Perea-Gomez,Natividad Bellido Carreras,Magali Dhellemmes et al.
Aitana Perea-Gomez et al.
Male genital development in XY mammalian fetuses is triggered by the action of hormones, including testosterone, secreted by the developing testes. Defects in this process are a cause for differences in sex development (DSD), one of the mos...
Stanislao Igor Travisano,Ching-Ling Lien
Stanislao Igor Travisano
Bioluminescent imaging is helping researchers better understand the effectiveness of tissue regeneration enhancers delivered to injured heart tissue by different adeno-associated virus vectors. ...
Editorial
eLife. 2025 Jul 10:14:e107945. DOI:10.7554/eLife.107945 2025
Correction: A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress [0.03%]
订正：酸性区-丝氨酸437处的磷酸开关控制镉暴露和神经退行性压力下的自噬反应
Nilay Nandi,Zuhair Zaidi,Charles Tracy et al.
Nilay Nandi et al.
Published Erratum
eLife. 2025 Jul 9:14:e108297. DOI:10.7554/eLife.108297 2025
Correction: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437 [0.03%]
订正：压力诱导的Cdk5活性通过磷酸化果蝇Acinus蛋白Ser437位点增强基础自噬作用
Nilay Nandi,Lauren K Tyra,Drew Stenesen et al.
Nilay Nandi et al.
Published Erratum
eLife. 2025 Jul 9:14:e108230. DOI:10.7554/eLife.108230 2025
A temporally restricted function of the dopamine receptor Dop1R2 during memory formation [0.03%]
一种多巴胺受体Dop1R2在记忆形成期间具有时空特异性的功能
Jenifer C Kaldun,Emanuele Calia,Ganesh Chinmai Bangalore Mukunda et al.
Jenifer C Kaldun et al.
Dopamine is a crucial neuromodulator involved in many brain processes, including learning and the formation of memories. Dopamine acts through multiple receptors and controls an intricate signaling network to regulate different tasks. While...
Le Zhang,Yunpeng Guan,YuenYee Cheng et al.
Le Zhang et al.
The killing mechanism of many antibiotics involves the induction of DNA damage, either directly or indirectly, which activates the SOS response. RecA, the master regulator of the SOS response, has been shown to play a central role in the ev...
Prebiotic gas flow environment enables isothermal nucleic acid replication [0.03%]
预生物气体流动环境可实现等温核酸复制
Philipp Schwintek,Emre Eren,Christof Bernhard Mast et al.
Philipp Schwintek et al.
Nucleic acid replication is a central process at the origin of life. On early Earth, replication is challenged by the dilution of molecular building blocks and the difficulty of separating daughter from parent strands, a necessity for expon...
Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information [0.03%]
味觉第二级神经元的分子特征揭示了味觉和代谢信息的整合机制
Rubén Mollá-Albaladejo,Manuel Jiménez-Caballero,Juan Antonio Sanchez-Alcaniz
Rubén Mollá-Albaladejo
Animals must balance the urgent need to find food during starvation with the critical necessity to avoid toxic substances to ensure their survival. In Drosophila, specialized Gustatory Receptors (GRs) expressed in Gustatory Receptor Neurons...
CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth [0.03%]
利用CRISPR技术使DPSCs持续表达BDNF可促进受损牙齿的牙本质再生
Ji Hyun Kim,Muhammad Irfan,Sreelekshmi Sreekumar et al.
Ji Hyun Kim et al.
Dental caries, a prevalent global health issue, results from complex bacterial interactions. In response to harmful stimuli, a desirable outcome for the tooth is the formation of tertiary dentin, a protective reparative process that generat...
Erdem Pulcu,Michael Browning
Erdem Pulcu
Efficient learning requires estimation of, and adaptation to, different forms of uncertainty. If uncertainty is caused by randomness in outcomes (noise), observed events should have less influence on beliefs, whereas if uncertainty is cause...