Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors [0.03%]
Saloni Goyal,Divya Rajendran,Anup Kumar Mani et al.
Saloni Goyal et al.
Disordered proteins and domains often assemble into condensates with polyanionic nucleic acids, primarily via charge complementarity, regulating numerous cellular functions. However, the assembly mechanisms associated with the other abundan...
Khoa Ngo,Pei-Chi Yang,Vladimir Yarov-Yarovoy et al.
Khoa Ngo et al.
To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been the resolution of discrete conformational stat...
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation [0.03%]
Li He,Jiayu Wen,Qi Dai
Li He
BMP signaling acts as an instructive cue in various developmental processes such as tissue patterning, stem cell proliferation, and differentiation. However, it is not fully understood how this signaling pathway generates different cell-spe...
Nathan Tardiff,Jiwon Kang,Joshua I Gold
Nathan Tardiff
The brain forms certain deliberative decisions following normative principles related to how sensory observations are weighed and accumulated over time. Previously we showed that these principles can account for how people adapt their decis...
Self-other generalisation shapes social interaction and is disrupted in borderline personality disorder [0.03%]
Joseph M Barnby,Jen Nguyen,Julia Griem et al.
Joseph M Barnby et al.
Generalising information from ourselves to others, and others to ourselves allows for both a dependable source of navigation and adaptability in interpersonal exchange. Disturbances to social development in sensitive periods can cause endur...
Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking [0.03%]
超慢速皮层纹状体血清素振荡定义了睡眠和清醒的次稳态
Claire Cooper,Daniel Parthier,Jeremie Sibille et al.
Claire Cooper et al.
Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter t...
The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut [0.03%]
微生物组与昼夜钟和饮食成分相互作用调节果蝇肠道代谢物循环
Yueliang Zhang,Sara B Noya,Yongjun Li et al.
Yueliang Zhang et al.
The gut microbiome plays a key role in the maintenance of host metabolic homeostasis and health. Most metabolic processes cycle with a 24-hour rhythm, but the extent to which the microbiome influences metabolite cycling under different cond...
Acquisition of auditory discrimination mediated by different processes through two distinct circuits linked to the lateral striatum [0.03%]
与侧纹状体相连的两条不同环路介导的听觉辨别获得的异同点研究
Susumu Setogawa,Takashi Okauchi,Di Hu et al.
Susumu Setogawa et al.
The striatum, the central hub of cortico-basal ganglia loops, contains functionally heterogeneous subregions distinguished by the topographic patterns of structural connectivity. These subregions mediate various processes of procedural lear...
The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target [0.03%]
foveation目标的显著性决定了其预测的时间和量级
Lisa M Kroell,Martin Rolfs
Lisa M Kroell
We previously demonstrated that during the preparation of a saccadic eye movement, human observers anticipate defining features of the eye movement target in pre-saccadic foveal vision (Kroell and Rolfs, 2022). In this Research Advance, we ...
Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus [0.03%]
溶菌酶感染驱动耐甲氧西林金黄色葡萄球菌丢失β-内酰胺类抗生素抗性
My Tran,Angel J Hernandez Viera,Patricia Q Tran et al.
My Tran et al.
Bacteriophage (phage) therapy is a promising means to combat drug-resistant bacterial pathogens. Infection by phage can select for mutations in bacterial populations that confer resistance against phage infection. However, resistance agains...