The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity [0.03%]
Sen-Lin Lai,Chris Q Doe
Sen-Lin Lai
Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combinations of transient spatial cues for their identity specification. This identity is then interpr...
Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice [0.03%]
Philip M M Ruppert,Aylin S Gueller,Marcus Skjæveland et al.
Philip M M Ruppert et al.
About 1 billion people are living with obesity worldwide. GLP-1-based drugs have massively transformed care, but long-term consequences are unclear in part due to reductions in energy expenditure with ongoing use. Diet-induced thermogenesis...
Timothy E Behrens,Yamini Dalal,Diane M Harper
Timothy E Behrens
Taking a radical new approach to the publication process resulted in eLife losing its impact factor, but authors, reviewers, editors and funders support the journal and its efforts to reform scientific publishing. ...
Editorial
eLife. 2026 Mar 17:15:e110392. DOI:10.7554/eLife.110392 2026
Alan J Aw,Lionel Chentian Jin,Nilah Ioannidis et al.
Alan J Aw et al.
Fine-mapping methods, which aim to identify genetic variants responsible for complex traits following genetic association studies, typically assume that sufficient adjustments for confounding within the association study cohort have been ma...
Siyuan Huang,Lan Wang,Sheng He
Siyuan Huang
Attentional distribution depends on both endogenous and exogenous processes, but how they interact in attentional allocation remains unclear. The attentional priority map, jointly determined by stimulus saliency and task relevance, provides...
Anurag A Agrawal,Amy P Hastings,Paola Rubiano-Buitrago
Anurag A Agrawal
In coevolutionary interactions, host plants accrue novel chemical defenses that specialist herbivores counter by detoxification and sometimes sequestration. We recently found unusual nitrogen- and sulfur-containing (N,S-) cardenolides in so...
Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain [0.03%]
Anisa Azatovna Gumerova,Georgii Pevnev,Funda Korkmaz et al.
Anisa Azatovna Gumerova et al.
Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary via the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure a...
Self-association enhances early attentional selection through automatic prioritization of socially salient signals [0.03%]
Meike Scheller,Jan Tünnermann,Katja Fredriksson et al.
Meike Scheller et al.
Efficiently processing self-related information is critical for cognition, yet the earliest mechanisms enabling this self-prioritization in humans remain unclear. By combining a temporal order judgement task with computational modeling base...
Antoine Bouyeure,Daniel Pacheco-Estefan,George Jacob et al.
Antoine Bouyeure et al.
When we learn that something is dangerous, a fear memory is formed. However, this memory is not fixed and can be updated through new experiences, such as learning that the threat is no longer present. This process of updating, known as exti...
Zachery Stephens,Julia Karasinska,Jochen Zimmer
Zachery Stephens
Hyaluronan (HA), a heteropolysaccharide of alternating N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA), is an essential component of the vertebrate extracellular matrix. HA biosynthesis proceeds via three evolutionarily convergent r...