Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening [0.03%]
通过高通量筛选鉴定KLHDC2配体实现靶向蛋白降解
Han Zhou,Tonglian Zhou,Wenli Yu et al.
Han Zhou et al.
Proteolysis-targeting chimeras (PROTACs) enable the selective and sub-stoichiometric elimination of pathological proteins, yet only two E3 ligases are routinely used for this purpose. Here, we expand the repertoire of PROTAC-compatible E3 l...
A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm [0.03%]
在冷漠、享乐缺失和晚型生物钟周期中与基于努力的决策相关的一种常见的神经递质变化
Sara Z Mehrhof,Camilla L Nord
Sara Z Mehrhof
Motivational deficits are common in several brain disorders, and motivational syndromes like apathy and anhedonia predict worse outcomes. Disrupted effort-based decision-making may represent a neurobiological underpinning of motivational de...
Jean Marc Tsagmo Ngoune,Parul Sharma,Aline Crouzols et al.
Jean Marc Tsagmo Ngoune et al.
Schuster et al. demonstrated that bloodstream slender forms of African trypanosomes are readily transmissible to young tsetse flies where they can complete their complex life cycle (Schuster et al., 2021). In their experimental conditions, ...
Morphology and ultrastructure of external sense organs of Drosophila larvae [0.03%]
果蝇幼虫外部感觉器官的形态和超微结构
Vincent Richter,Anna Rist,Georg Kislinger et al.
Vincent Richter et al.
Sensory perception is the ability through which an organism is able to process sensory stimuli from the environment. This stimulus is transmitted from the peripheral sensory organs to the central nervous system, where it is interpreted. Dro...
Xicong Tang,Hongyu Qiu
Xicong Tang
The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer. Keywords: ...
Editorial
eLife. 2025 Jun 16:14:e107882. DOI:10.7554/eLife.107882 2025
Atit A Patel,Albert Cardona,Daniel N Cox
Atit A Patel
Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus-specific behaviors to eit...
A multiplex of connectome trajectories enables several connectivity patterns in parallel [0.03%]
多重连接组轨迹的组合可同时使多种连接模式成为可能
Parham Mostame,Jonathan Wirsich,Thomas Alderson et al.
Parham Mostame et al.
Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are facil...
BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus [0.03%]
BCAS2通过将β-连环蛋白限制在细胞核内来促进原始血液生成
Guozhu Ning,Yu Lin,Haixia Ma et al.
Guozhu Ning et al.
Breast carcinoma amplified sequence 2 (BCAS2), a core component of the hPrP19 complex, plays crucial roles in various physiological and pathological processes. However, whether BCAS2 has functions other than being a key RNA-splicing regulat...
Precise spatial tuning of visually driven alpha oscillations in human visual cortex [0.03%]
人类视觉皮层中视觉驱动的alpha振荡的精确空间调谐
Kenichi Yuasa,Iris I A Groen,Giovanni Piantoni et al.
Kenichi Yuasa et al.
Neuronal oscillations at about 10 Hz, called alpha oscillations, are often thought to arise from synchronous activity across the occipital cortex and are usually largest when the cortex is inactive. However, recent studies measuring visual ...
Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force [0.03%]
指尖的黏弹性使人类触觉神经元能够同时编码加载历史和当前力大小
Hannes P Saal,Ingvars Birznieks,Roland S Johansson
Hannes P Saal
Human skin and its underlying tissues constitute a viscoelastic medium, implying that any deformation depends not only on the currently applied force, but also on the recent loading history. The extent to which this physical memory influenc...