Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer [0.03%]
幽门螺杆菌相关胃癌的单细胞解剖学：预后结构和免疫治疗反应
Xin Zhang,Guangyu Zhang,Shuli Sang et al.
Xin Zhang et al.
Most of the human gastric cancer (GC) worldwide are ascribed to Helicobacter pylori infections, which have a detrimental effect on the immunotherapy's efficacy. Comprehensively dissecting the key cell players and molecular pathways associat...
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality [0.03%]
探究虚拟现实的固定小鼠条件化恐惧的情景模式
Seetha Krishnan,Can Dong,Heather Ratigan et al.
Seetha Krishnan et al.
Contextual fear conditioning (CFC) is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous opportunities to understand the ne...
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification [0.03%]
PI3Kα抑制可阻止骨软骨祖细胞的分化并阻断过度炎症反应以防止异位骨化
José Antonio Valer,Alexandre Deber,Marius Wits et al.
José Antonio Valer et al.
Heterotopic ossification (HO) occurs following mechanical trauma and burns, or congenitally in patients suffering from fibrodysplasia ossificans progressiva (FOP). Recently, we demonstrated that inhibitors of phosphatidylinositol 3-kinase a...
Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons [0.03%]
斑马鱼嗅觉感觉神经元中的执行者半胱天冬酶及其非致命激活促进因子Fas3的功能与机制研究
Masaya Muramoto,Nozomi Hanawa,Misako Okumura et al.
Masaya Muramoto et al.
The nervous system undergoes functional modification independent of cell turnover. Caspase participates in reversible neuronal modulation via non-lethal activation. However, the mechanism that enables non-lethal activation remains unclear. ...
CARD8 inflammasome activation during HIV-1 cell-to-cell transmission [0.03%]
HIV-1细胞间传播过程中CARD8炎症小体的活化
Jessie Kulsuptrakul,Michael Emerman,Patrick S Mitchell
Jessie Kulsuptrakul
Our previous work demonstrated that CARD8 detects HIV-1 infection by sensing the enzymatic activity of the HIV protease, resulting in CARD8-dependent inflammasome activation (Kulsuptrakul et al., 2023). CARD8 harbors a motif in its N-termin...
Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation [0.03%]
母体在哺乳期摄入高脂饮食通过小胶质细胞影响子代下丘脑AgRP神经元的投射及功能Specification of AgRP neuronal projections and function by microglia
Haley N Mendoza-Romero,Jessica E Biddinger,Michelle N Bedenbaugh et al.
Haley N Mendoza-Romero et al.
Agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus respond to multiple metabolic signals and distribute neuroendocrine information to other brain regions such as the paraventricular hypothalamic nucleus (PVH), ...
Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences [0.03%]
预测性学习规则产生类似皮层的回放，再现概率感觉体验
Toshitake Asabuki,Tomoki Fukai
Toshitake Asabuki
The brain is thought to construct an optimal internal model representing the probabilistic structure of the environment accurately. Evidence suggests that spontaneous brain activity gives such a model by cycling through activity patterns ev...
Joel Dokmegang,Emmanuel Faure,Patrick Lemaire et al.
Joel Dokmegang et al.
Describing morphogenesis generally consists in aggregating the multiple high-resolution spatiotemporal processes involved into reproducible low-dimensional morphological processes consistent across individuals of the same species or group. ...
Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila [0.03%]
四项独立识别的多巴胺配对神经元在果蝇幼虫味觉惩罚信号转导中的作用
Denise Weber,Katrin Vogt,Anton Miroschnikow et al.
Denise Weber et al.
Dopaminergic neurons (DANs) play key roles in processing rewards and punishments across species. They evaluate sensory input, store memories, and update them based on relevance. To understand how individual DANs contribute to these function...
Rate of brain aging associates with future executive function in Asian children and older adults [0.03%]
大脑衰老速度与亚洲儿童和老年人的未来执行功能有关
Susan F Cheng,Wan Lin Yue,Kwun Kei Ng et al.
Susan F Cheng et al.
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. F...