Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages [0.03%]
沙门氏菌利用宿主和细菌来源的β-丙氨酸在宿主巨噬细胞内复制
Shuai Ma,Bin Yang,Yuyang Sun et al.
Shuai Ma et al.
Salmonella is a major foodborne pathogen that can effectively replicate inside host macrophages to establish life-threatening systemic infections. Salmonella must utilize diverse nutrients for growth in nutrient-poor macrophages, but which ...
Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate [0.03%]
cipargamin作为抗巴贝斯虫病候选药物的疗效及作用机制研究
Hang Li,Shengwei Ji,Nanang R Ariefta et al.
Hang Li et al.
Babesiosis is a disease brought on by intraerythrocytic parasites of the genus Babesia. Current chemotherapies are accompanied by side effects and parasite relapse. Therefore, it is crucial to develop highly effective drugs against Babesia....
Retraction: Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers [0.03%]
撤稿：靶向RIOK1的翻译后修饰可抑制结直肠癌和胃癌的发展
Xuehui Hong,He Huang,Xingfeng Qiu et al.
Xuehui Hong et al.
Shamayita Roy,Claus M Azzalin
Shamayita Roy
Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells. Keyword...
Editorial
eLife. 2025 Jun 18:14:e107648. DOI:10.7554/eLife.107648 2025
In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate [0.03%]
在小鼠中，特定气味能选择性地促进与其刺激的感受神经元亚型的新生神经系统发育
Kawsar Hossain,Madeline Smith,Karlin E Rufenacht et al.
Kawsar Hossain et al.
In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to replace neurons lost via turnover or injury. This assumption follows from the hypothesis that olfactory neurogenesis is stochastic with respect to n...
Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona [0.03%]
刺胞蛋白信号中继驱动cAMP积累以及时完成草履虫的变态发育
Akiko Hozumi,Nozomu M Totsuka,Arata Onodera et al.
Akiko Hozumi et al.
Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via their adhesive organ. The gap between adhesion and metamorphosis initiation is suggested to ensure the rigidity of adhesion, allowing Cio...
A causal role of the NMDA receptor in recurrent processing during perceptual integration [0.03%]
NMDA受体在感知整合过程中反复处理的因果作用
Samuel Noorman,Timo Stein,Jasper Zantvoord et al.
Samuel Noorman et al.
Perceptual inference requires the integration of visual features through recurrent processing, the dynamic exchange of information between higher- and lower-level cortical regions. While animal research has demonstrated a crucial role of NM...
Randomized Controlled Trial
eLife. 2025 Jun 18:13:RP100530. DOI:10.7554/eLife.100530 2025
A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning [0.03%]
基于机器学习的放射敏感性预测基因模型在鼻咽癌中效果良好
Kailai Li,Junyi Liang,Nan Li et al.
Kailai Li et al.
Radiotherapy resistance in nasopharyngeal carcinoma (NPC) is a major cause of recurrence and metastasis. Identifying radiotherapy-related biomarkers is crucial for improving patient survival outcomes. This study developed the nasopharyngeal...
Shu Li,Yi Zou,Austin McMasters et al.
Shu Li et al.
In the past, immune memory was considered an exclusive feature of the adaptive immune system. However, accumulating evidence suggests that the innate immune system, the most primitive and fundamental component of immunity, can mount more ro...
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling [0.03%]
糖酵解通量通过调节Wnt信号控制视网膜祖细胞分化
Joseph Hanna,Yacine Touahri,Alissa Pak et al.
Joseph Hanna et al.
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is re...