CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy [0.03%]
一种用于荧光显微镜的自我监督三维细胞分割方法（CellSeg3D）
Cyril Achard,Timokleia Kousi,Markus Frey et al.
Cyril Achard et al.
Understanding the complex three-dimensional structure of cells is crucial across many disciplines in biology and especially in neuroscience. Here, we introduce a set of models including a 3D transformer (SwinUNetR) and a novel 3D self-super...
Zezhen Wang,Weihao Mai,Yuming Chai et al.
Zezhen Wang et al.
Understanding neural activity organization is vital for deciphering brain function. By recording whole-brain calcium activity in larval zebrafish during hunting and spontaneous behaviors, we find that the shape of the neural activity space,...
Cora Fischer,Jochen Kaiser,Christoph Bledowski
Cora Fischer
Serial dependence describes the phenomenon that current object representations are attracted to previously encoded and reported representations. While attractive biases have been observed reliably in behavior, a direct neural correlate has ...
Synaptic connectivity of sensorimotor circuits for vocal imitation in the songbird [0.03%]
鸣鸟声音模拟的感觉运动通路的突触连接性研究
Massimo Trusel,Ziran Zhao,Danyal H Alam et al.
Massimo Trusel et al.
Sensorimotor computations for learning and behavior rely on precise patterns of synaptic connectivity. Yet, we typically lack the synaptic wiring diagrams for long-range connections between sensory and motor circuits in the brain. Here, we ...
Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex [0.03%]
没有内侧前额叶皮层的认知控制和海马信息加工
Eun Hye Park,Kally C O&#x;Reilly Sparks,Griffin Grubbs et al.
Eun Hye Park et al.
Cognitive control tasks require using one class of information while ignoring competing classes of information. The central role of the medial prefrontal cortex (mPFC) in cognitive control is well established in the primate literature and l...
Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia [0.03%]
脑源性外泌体血红蛋白向缺氧环境下的神经元线粒体转运贡献度的研究
Zhengming Tian,Yuning Li,Feiyang Jin et al.
Zhengming Tian et al.
Hypoxia is an important physiological stress causing nerve injuries and several brain diseases. However, the mechanism of brain response to hypoxia remains unclear, thus limiting the development of interventional strategies. This study cond...
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis [0.03%]
猪链球菌荚膜多糖的调控合成及其致病性研究
Xingye Wang,Jie Wang,Ning Li et al.
Xingye Wang et al.
Streptococcus suis (S. suis) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a virul...
PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin [0.03%]
PDZ介导的底物募集是PP1-Neurabin特异性去磷酸化4E-BP1的主要决定因素
Roman O Fedoryshchak,Karim El-Bouri,Dhira Joshi et al.
Roman O Fedoryshchak et al.
Phosphoprotein phosphatase 1 (PP1) relies on association with PP1-interacting proteins (PIPs) to generate substrate-specific PIP/PP1 holoenzymes, but the lack of well-defined substrates has hindered elucidation of the mechanisms involved. W...
Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches [0.03%]
来自瞳孔测量、fMRI和RNN建模的证据表明，增益神经调节介导了与任务相关的感觉开关
Gabriel Wainstein,Christopher J Whyte,Kaylena A Ehgoetz Martens et al.
Gabriel Wainstein et al.
Perceptual updating has been hypothesised to rely on a network reset modulated by bursts of ascending neuromodulatory neurotransmitters, such as noradrenaline, abruptly altering the brain's susceptibility to changing sensory activity. To te...
Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR [0.03%]
利用HiCapR绘制HIV-1 RNA结构、同二聚体、长程相互作用和持久域地图
Yan Zhang,Jingwan Han,Xie Dejian et al.
Yan Zhang et al.
Human Immunodeficiency Virus type 1 (HIV-1) RNA genome organization remains a critical knowledge gap in understanding its replication cycle. To address this, we developed HiCapR, a psoralen crosslinking-based RNA proximity ligation method c...