Mirela Zaneva,Tao Coll-Martín,Yseult Héjja-Brichard et al.
Mirela Zaneva et al.
Since its inception, the concept of neurodiversity has been defined in a number of different ways, which can cause confusion among those hoping to educate themselves about the topic. Learning about neurodiversity can also be challenging bec...
Amanda D Melin
Amanda D Melin
Studying the fecal microbiota of wild baboons helps provide new insight into the factors that influence biological aging. Keywo...
Editorial
eLife. 2024 Dec 3:13:e104715. DOI:10.7554/eLife.104715 2024
RNA tertiary structure and conformational dynamics revealed by BASH MaP [0.03%]
BASH MaP揭示的RNA三级结构及构象动力学
Maxim Oleynikov,Samie R Jaffrey
Maxim Oleynikov
The functional effects of an RNA can arise from complex three-dimensional folds known as tertiary structures. However, predicting the tertiary structure of an RNA and whether an RNA adopts distinct tertiary conformations remains challenging...
Nasa Sinnott-Armstrong,Stanley Fields,Frederick Roth et al.
Nasa Sinnott-Armstrong et al.
Over the last three decades, human genetics has gone from dissecting high-penetrance Mendelian diseases to discovering the vast and complex genetic etiology of common human diseases. In tackling this complexity, scientists have discovered t...
Jessica Royer,Valeria Kebets,Camille Piguet et al.
Jessica Royer et al.
Complex structural and functional changes occurring in typical and atypical development necessitate multidimensional approaches to better understand the risk of developing psychopathology. Here, we simultaneously examined structural and fun...
Sympathetic motor neuron dysfunction is a missing link in age-associated sympathetic overactivity [0.03%]
交感神经元功能障碍是年龄相关性交感神经亢进缺失环节
Lizbeth de La Cruz,Derek Bui,Claudia M Moreno et al.
Lizbeth de La Cruz et al.
Overactivity of the sympathetic nervous system is a hallmark of aging. The cellular mechanisms behind this overactivity remain poorly understood, with most attention paid to likely central nervous system components. In this work, we hypothe...
TPR is required for cytoplasmic chromatin fragment formation during senescence [0.03%]
TPR在衰老过程中形成胞质染色质片段所必需
Bethany M Bartlett,Yatendra Kumar,Shelagh Boyle et al.
Bethany M Bartlett et al.
During oncogene-induced senescence there are striking changes in the organisation of heterochromatin in the nucleus. This is accompanied by activation of a pro-inflammatory gene expression programme - the senescence-associated secretory phe...
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model [0.03%]
利用rhPTH（1-34）和二聚体R25CPTH（1-34）促进骨质疏松/beagle模型中骨再生和骨整合
Jeong-Oh Shin,Jong-Bin Lee,Sihoon Lee et al.
Jeong-Oh Shin et al.
This study investigates the effects of two parathyroid hormone (PTH) analogs, rhPTH(1-34) and dimeric R25CPTH(1-34), on bone regeneration and osseointegration in a postmenopausal osteoporosis model using beagle dogs. Twelve osteoporotic fem...
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells [0.03%]
钾通道亚基KV1.8（Kcna10）对于I型和II型前庭毛细胞独特的外向整流电导至关重要
Hannah R Martin,Anna Lysakowski,Ruth Anne Eatock
Hannah R Martin
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, gK,L, which activates...
An acute microglial metabolic response controls metabolism and improves memory [0.03%]
急性小胶质细胞代谢反应控制代谢并改善记忆
Anne Drougard,Eric H Ma,Vanessa Wegert et al.
Anne Drougard et al.
Chronic high-fat feeding triggers metabolic dysfunction including obesity, insulin resistance, and diabetes. How high-fat intake first triggers these pathophysiological states remains unknown. Here, we identify an acute microglial metabolic...