γδ T cell characterisation in the long term after haematopoietic stem cell transplantation and its impact on CMV control and cGVHD severity [0.03%]
造血干细胞移植后长时间的γδT细胞特征及其对CMV控制和cGVHD严重性的影响
Faisal Alagrafi,Arwen Stikvoort,Ahmed Gaballa et al.
Faisal Alagrafi et al.
Objectives: The clinical outcome after allogeneic haematopoietic stem cell transplantation (aHCT) relies greatly on the efficient recovery of T cells. Several studies have investigated the short-term γδ T cell reconstit...
Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity [0.03%]
血液和气道中树突状细胞的水平和功能降低可预测COVID-19疾病的严重程度
Björn Österberg,Sara Falck-Jones,Sindhu Vangeti et al.
Björn Österberg et al.
Objectives: Monocytes and dendritic cells (DCs) are essential players in the immune response to infections, involved in shaping innate and adaptive immunity. However, a complete understanding of their specific roles in re...
Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients [0.03%]
与急诊科患者脓毒症临床结果相关的不同MAIT细胞表型
Johanna Emgård,Iva Filipovic,Christian Unge et al.
Johanna Emgård et al.
Objectives: Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents...
Lightson Ngashangva,Sunil Martin
Lightson Ngashangva
Despite great strides of progress, at least 60% of the responding patients relapse to CAR therapy across the blood malignancies. Off-tumor toxicity apart from functional deficits, cytopenia and infection are the major unfavourable effect of...
Effect of Bacille Calmette-Guérin vaccination on immune responses to SARS-CoV-2 and COVID-19 vaccination [0.03%]
卡介苗接种对机体SARS-CoV-2感染免疫反应和COVID-19疫苗接种免疫反应的影响
Nicole L Messina,Susie Germano,Amy W Chung et al.
Nicole L Messina et al.
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG va...
Eleni Tiniakou,Livia Casciola-Rosen,Mekha A Thomas et al.
Eleni Tiniakou et al.
Objectives: CD209L and its homologous protein CD209 act as alternative entry receptors for the SARS-CoV-2 virus and are highly expressed in the virally targeted tissues. We tested for the presence and clinical features of...
A preclinical study of allogeneic CD19 chimeric antigen receptor double-negative T cells as an off-the-shelf immunotherapy drug against B-cell malignancies [0.03%]
同种异体CD19嵌合抗原受体双阴性T细胞治疗B细胞肿瘤的现货型药物的临床前研究
Dan Wang,Liuyang Wang,Shuai Liu et al.
Dan Wang et al.
Objectives: To evaluate the manufacturability, efficacy and safety of allogeneic CD19 chimeric antigen receptor double-negative T cells (CD19-CAR-DNTs) as an off-the-shelf therapeutic cell product. ...
Improving diagnosis in patients with obstetric antiphospholipid syndrome through the evaluation of non-criteria antibodies [0.03%]
通过评估非标准抗体改善产科抗磷脂综合征患者的诊断
Daniel Álvarez,Hephzibah E Winter,Carlos J Velasquez Franco et al.
Daniel Álvarez et al.
Objectives: Antiphospholipid syndrome (APS) is an autoimmune disease driven by antiphospholipid antibodies (aPL). Currently, APS diagnosis requires a combination of clinical manifestations (thrombosis and/or obstetric mor...
From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL-33 [0.03%]
从实验室到临床：TSLP和IL-33的2型上皮细胞因子与肥大细胞的功能关系
Kazushige Obata-Ninomiya,Tharmalingam Jayaraman,Steven F Ziegler
Kazushige Obata-Ninomiya
Type 2 epithelial cytokines, including thymic stromal lymphopoietin and IL-33, play central roles in modulation of type 2 immune cells, such as basophils. Basophils are a small subset of granulocytes within the leukocyte population that pre...
Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen-processing-presentation machinery and poor patient survival [0.03%]
鳞状细胞癌与白介素34表达降低、朗格汉斯细胞抗原加工呈递机器的改变及患者预后不良相关
Thi Viet Trinh Dang,Kevin R Gillinder,Quan Nguyen et al.
Thi Viet Trinh Dang et al.
Objectives: Langerhans cells (LCs) are epithelial antigen-presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechani...