Autologous Epstein-Barr virus-specific adoptive T-cell therapy in a patient with lupus nephritis [0.03%]
自身Epstein-Barr病毒特异性过继T细胞治疗系统性红斑狼疮伴发的狼疮性肾炎患者
Dwarakanathan Ranganathan,Saskia Leibowitz,George T John et al.
Dwarakanathan Ranganathan et al.
Objectives: Dysregulation of Epstein-Barr virus (EBV)-specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a maj...
Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission [0.03%]
天然杀伤细胞的抗体依赖性细胞毒性受细胞表型、红细胞多态性、寄生虫多样性和传播强度的影响
Stephen Tukwasibwe,Savannah Nicole Lewis,Yoweri Taremwa et al.
Stephen Tukwasibwe et al.
Objectives: Natural killer (NK) cells make important contributions to anti-malarial immunity through antibody-dependent cellular cytotoxicity (ADCC), but the role of different components of this pathway in promoting NK ce...
Inhibitory effect of hydroxychloroquine on glucocorticoid-induced osteoporosis in lupus therapy [0.03%]
羟氯喹对狼疮治疗中糖皮质激素所致骨质疏松的抑制作用
Wenlin Qiu,Xiaoxiao Han,Tong Yu et al.
Wenlin Qiu et al.
Objectives: Systemic lupus erythematosus (SLE) is a chronic and severe autoimmune disease characterised by persistent inflammation. Hydroxychloroquine (HCQ) and glucocorticoids (GCs) are the primary agents commonly used i...
IL-15-induced CD38+HLA-DR+CD8+ T cells correlate with liver injury via NKG2D in chronic hepatitis B cirrhosis [0.03%]
慢性乙型肝炎肝硬化患者中IL-15诱导的CD38+HLA-DR+CD8+T细胞通过NKG2D与肝脏损伤相关
Jing Fan,Min Xu,Ke Liu et al.
Jing Fan et al.
Objectives: CD8+ T cells play a critical role in the immune dysfunction associated with liver cirrhosis. CD38+HLA-DR+CD8+ T cells, or bystander-activated CD8+ T cells, are involved in tissue injury but their specific cont...
Naturally acquired adaptive immunity to Streptococcus pneumoniae is impaired in rheumatoid arthritis patients [0.03%]
类风湿关节炎患者的自然获得性肺炎链球菌适应性免疫受损
Giuseppe Ercoli,Hugh Selway-Clarke,Dena Truijen et al.
Giuseppe Ercoli et al.
Objectives: Patients with rheumatoid arthritis (RA) have an increased susceptibility to infections, including those caused by Streptococcus pneumoniae. Why RA is associated with increased susceptibility to S. pneumoniae i...
Lymphocyte activation gene 3 served as a potential prognostic and immunological biomarker across various cancer types: a clinical and pan-cancer analysis [0.03%]
淋巴细胞活化基因3可作为多种癌症类型中的潜在预后和免疫学生物标志物：临床及泛癌分析
Yifan Liu,Yuntao Yao,Xinyue Yang et al.
Yifan Liu et al.
Objectives: Lymphocyte activation gene 3 (LAG3), an inhibitory receptor in T-cell activation, is a negative prognostic factor. However, its impact on tumours has yet to be comprehensively elucidated on a pan-cancer scale....
Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS-CoV-2 Omicron infection [0.03%]
接种疫苗与未接种疫苗的儿童感染奥密克戎株后的体液及细胞免疫反应
Zheng Quan Toh,Jeremy Anderson,Nadia Mazarakis et al.
Zheng Quan Toh et al.
Objectives: The immune response in children elicited by SARS-CoV-2 Omicron infection alone or in combination with COVID-19 vaccination (hybrid immunity) is poorly understood. We examined the humoral and cellular immune re...
Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells [0.03%]
抗CD38单克隆抗体通过破坏儿童Burkitt淋巴瘤恶性B细胞的关键生存途径发挥抗癌作用
Kathrin Kläsener,Nadja Herrmann,Liliana Håversen et al.
Kathrin Kläsener et al.
Objectives: Paediatric Burkitt's lymphoma (pBL) is the most common childhood non-Hodgkin B-cell lymphoma. Despite the encouraging survival rates for most children, treating cases with relapse/resistance to current therapi...
Characteristics of PD-1+CD4+ T cells in peripheral blood and synovium of rheumatoid arthritis patients [0.03%]
类风湿关节炎患者外周血和滑膜组织中PD-1+CD4+T细胞的特征分析
Yan-Juan Chen,Yong Chen,Ping Chen et al.
Yan-Juan Chen et al.
Objectives: PD-1 plays a crucial role in the immune dysregulation of rheumatoid arthritis (RA), but the specific characteristics of PD-1+CD4+ T cells remain unclear and require further investigation. ...
Cord blood granulocyte levels are associated with severe bronchiolitis in the first year of life [0.03%]
新生儿脐带血中性粒细胞水平与婴儿第一年内发生重症毛细支气管炎有关
Gabriela Martins Costa Gomes,Carla Rebeca Da Silva Sena,Vanessa E Murphy et al.
Gabriela Martins Costa Gomes et al.
Objectives: Bronchiolitis is a leading cause of infant hospitalisation in the first year of life, and it preferentially affects infants born to mothers with asthma. Here, we evaluate cord blood granulocytes in infants bor...