Clinical, biological and cytometric characteristics of two patients with a homozygous A91V PRF1 mutation [0.03%]
两项研究显示两名患者的临床特征、生物特征及细胞计量学特征均具有PRF1基因纯合子A91V突变的特征
Nicolas Perrard,Claire Poggi,Sébastien Sanges et al.
Nicolas Perrard et al.
Objectives: Inborn errors of immunity are rare genetic disorders that cause dysfunction of the immune system. Among these, familial haemophagocytic lymphohistiocytosis (FHL) involves defects in the perforin/granzyme pathw...
Effect of CXCR5, PD-1 and ICOS on B-cell responses and relevance to myasthenia gravis [0.03%]
CXCR5、PD-1和ICOS对B细胞反应的影响及其与重症肌无力的关系
Merve Çebi,Arman Çakar,Hacer Durmuş et al.
Merve Çebi et al.
Objectives: T follicular helper (Tfh) cells regulate B-cell responses within germinal centres primarily via programmed cell death protein 1 (PD-1) and inducible T-cell costimulator (ICOS), whereas CXC chemokine receptor t...
Development and functional adaptation of intestinal macrophages across the lifespan [0.03%]
生命周期中肠巨噬细胞的发育及其功能适应性变迁
Baha Mustafa,Elisa L Hill-Yardin,Sarah J Spencer
Baha Mustafa
Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional diversification and life stage-specific roles remain incompletely integrated. This review aimed to p...
Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity [0.03%]
饮食诱导的肥胖期间髓系HDAC7驱动肝炎和全身血糖紊乱
Yizhuo Wang,Divya Ramnath,Kaustav Das Gupta et al.
Yizhuo Wang et al.
Objectives: Histone deacetylase 7 (HDAC7), a classical HDAC family member, promotes LPS-inducible glycolysis and inflammatory mediator production in macrophages, innate immune cells that contribute to pathology in metabol...
Single-cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy [0.03%]
单细胞和谱系分析揭示了儿童上呼吸道的免疫重塑：来自腺样增生的启示
Chao Wang,Yufei Pan,Xiao Han et al.
Chao Wang et al.
Objectives: To characterise the immune cellular landscape and paired B-cell and T-cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea. ...
Control of poorly immunogenic tumors with systemic STING agonist-loaded liposomes targeting cross-presenting dendritic cells [0.03%]
控制难以免疫的肿瘤与全身刺激基因表达诱导物载脂膜囊素以靶向交叉呈递树突细胞
Bijun Zeng,Meghna Talekar,Thais Aragao-Horoiwa et al.
Bijun Zeng et al.
Objectives: Cancer vaccines combine tumor antigen and adjuvant to drive an anti-tumor immune response. Clec9A-targeted nanoparticles directing CD4 and CD8 neo-epitopes to cross-presenting dendritic cells (DCs) stimulate a...
Alterations of circulating innate lymphoid cells in recent-onset type 1 diabetes [0.03%]
新发1型糖尿病患者循环天然淋巴样细胞的改变
Ariadna Roig,David Perna-Barrull,Eva Aguilera et al.
Ariadna Roig et al.
Objectives: Type 1 diabetes (T1D) is driven by autoreactive T lymphocytes with contributions from innate immune compartments, yet early innate immune alterations associated with autoimmune amplification remain incompletel...
Aberrant intra-epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103-β7-receptor-mediated granzyme-B degranulation which can be restored by etrolizumab [0.03%]
难治性乳糜泻中上皮内淋巴细胞通过CD103-β7受体介导的穿孔素依赖性粒酶B裂解引起吸收细胞死亡，伊特奥利珠单抗可以治疗
Daan A R Castelijn,Jolanda M W van de Water,Laura R de Baaij et al.
Daan A R Castelijn et al.
Objectives: Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra-epithelial T-lymphocytes (IEL). The severe enteropathy found in RCDII is caused by aberrant IEL that exert cytotoxicity agains...
Characterisation of tumor-infiltrating gamma-delta T cells in human colorectal cancer with MHC-I loss [0.03%]
人结直肠癌中MHC-I丢失的肿瘤浸润性γδT细胞的表征
Tianming A Li,Luke T Quigley,Kok Fei Chan et al.
Tianming A Li et al.
Objectives: Gamma-delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhib...
A novel case of autosomal recessive CARD11 loss-of-function underlying impaired antiviral immunity and a review of literature [0.03%]
CARD11功能丧失导致的自身免疫缺陷综合症病例报道及文献复习
Hamish Anderson,Cecilia Verryt,Paula Keating et al.
Hamish Anderson et al.
Objectives: Germline CARD11 variants lead to a spectrum of disease depending on the effect of signalling augmentation or impairment. Autosomal recessive (AR) CARD11 loss-of-function (LOF) is rare with only 12 cases report...