Effect of Bacille Calmette-Guérin vaccination on immune responses to SARS-CoV-2 and COVID-19 vaccination [0.03%]
卡介苗接种对机体SARS-CoV-2感染免疫反应和COVID-19疫苗接种免疫反应的影响
Nicole L Messina,Susie Germano,Amy W Chung et al.
Nicole L Messina et al.
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG va...
Eleni Tiniakou,Livia Casciola-Rosen,Mekha A Thomas et al.
Eleni Tiniakou et al.
Objectives: CD209L and its homologous protein CD209 act as alternative entry receptors for the SARS-CoV-2 virus and are highly expressed in the virally targeted tissues. We tested for the presence and clinical features of...
A preclinical study of allogeneic CD19 chimeric antigen receptor double-negative T cells as an off-the-shelf immunotherapy drug against B-cell malignancies [0.03%]
同种异体CD19嵌合抗原受体双阴性T细胞治疗B细胞肿瘤的现货型药物的临床前研究
Dan Wang,Liuyang Wang,Shuai Liu et al.
Dan Wang et al.
Objectives: To evaluate the manufacturability, efficacy and safety of allogeneic CD19 chimeric antigen receptor double-negative T cells (CD19-CAR-DNTs) as an off-the-shelf therapeutic cell product. ...
Improving diagnosis in patients with obstetric antiphospholipid syndrome through the evaluation of non-criteria antibodies [0.03%]
通过评估非标准抗体改善产科抗磷脂综合征患者的诊断
Daniel Álvarez,Hephzibah E Winter,Carlos J Velasquez Franco et al.
Daniel Álvarez et al.
Objectives: Antiphospholipid syndrome (APS) is an autoimmune disease driven by antiphospholipid antibodies (aPL). Currently, APS diagnosis requires a combination of clinical manifestations (thrombosis and/or obstetric mor...
From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL-33 [0.03%]
从实验室到临床：TSLP和IL-33的2型上皮细胞因子与肥大细胞的功能关系
Kazushige Obata-Ninomiya,Tharmalingam Jayaraman,Steven F Ziegler
Kazushige Obata-Ninomiya
Type 2 epithelial cytokines, including thymic stromal lymphopoietin and IL-33, play central roles in modulation of type 2 immune cells, such as basophils. Basophils are a small subset of granulocytes within the leukocyte population that pre...
Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen-processing-presentation machinery and poor patient survival [0.03%]
鳞状细胞癌与白介素34表达降低、朗格汉斯细胞抗原加工呈递机器的改变及患者预后不良相关
Thi Viet Trinh Dang,Kevin R Gillinder,Quan Nguyen et al.
Thi Viet Trinh Dang et al.
Objectives: Langerhans cells (LCs) are epithelial antigen-presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechani...
Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals [0.03%]
活化方案的选择影响CAR-T产品的产量和质量，尤其是老年人群中
Palak H Mehta,Gemma S Trollope,Patrick Leung et al.
Palak H Mehta et al.
Objectives: In clinical chimeric antigen receptor (CAR) T cell therapy, one of the strongest correlates of favorable patient responses is lower levels of differentiation in T cells from the peripheral blood mononuclear ce...
CD8+ T cell epitope conservation in emerging H5N1 viruses suggests global protection [0.03%]
新兴H5N1病毒的CD8+t细胞表位保守性提示其可能提供全球保护作用
Emma J Grant,Stephanie Gras
Emma J Grant
Objectives: The recent H5N1 avian influenza outbreak in the USA has sparked fresh fears of avian viruses causing the next pandemic. To date, the H5N1 (clade 2.3.4.4b) outbreak in cattle has spread across several states in...
Dual CD47 and PD-L1 blockade elicits anti-tumor immunity by intratumoral CD8+ T cells [0.03%]
CD47和PD-L1双阻滞通过瘤内CD8+t细胞发挥抗肿瘤免疫作用
Susan N Christo,Keely M McDonald,Thomas N Burn et al.
Susan N Christo et al.
Objectives: Bispecific antibodies targeting CD47 and PD-L1 (CD47 × PD-L1 BisAb) demonstrate efficacy against a range of solid cancers. While dual blockade negates anti-CD47-mediated toxicity, the effect of combined innat...
The contribution of the CRP/CD64 axis to renal cancer progression by inducing protumor activation of tumor-associated macrophages [0.03%]
CRP/CD64轴通过诱导肿瘤相关巨噬细胞的促肿瘤活化促进肾癌进展
Cheng Pan,Yukio Fujiwara,Hiromu Yano et al.
Cheng Pan et al.
Objectives: C-reactive protein (CRP) is a well-known acute-phase protein that increases remarkably under various inflammatory conditions and is elevated in patients with malignant tumors. In this study, we investigated th...