Functional characterisation of CD8+ T cells mobilised with acute supramaximal high-intensity interval exercise: implications for immune surveillance [0.03%]
高强度间歇运动调动的CD8⁺T细胞的功能表征及其对免疫监视的意义
Anna Strömberg,Mirko Mandić,Brennan J Wadsworth et al.
Anna Strömberg et al.
Objectives: The beneficial influence of exercise on outcomes such as infection control and cancer prevention has been attributed partly to the immune system response during physical exertion. CD8+ T cells play a crucial r...
Long-lasting changes in circulating dendritic cell and monocyte subsets, and altered expression of EMR2, CD97 and EMR3 on these cells in the posttraumatic course [0.03%]
创伤后循环中树突状细胞和单核细胞亚群的长期变化及其在这些细胞上EMR2、CD97和EMR3表达的改变
Leyu Zheng,Carolin Fuchs,Christian Kleber et al.
Leyu Zheng et al.
Objectives: Traumatic injury triggers the rapid release of damage-associated patterns (DAMPs). Dendritic cells (DCs) and monocytes play key roles in sensing, processing, and presenting DAMPs to naïve T cells. These heter...
Allogeneic 'off-the-shelf' SARS-CoV-2-specific adoptive T-cell therapy for refractory viral infection and end organ disease [0.03%]
针对难治性病毒性感染和靶器官损伤的同种异体“即用型”SARS-CoV-2特异性过继性T细胞治疗
Andrea S Henden,Katie E Lineburg,Archana Panikkar et al.
Andrea S Henden et al.
Objectives: Despite the effective roll-out of COVID-19 vaccines, immunocompromised patients have a higher risk of morbidity and mortality following SARS-CoV-2 infection. Allogeneic adoptive T-cell immunotherapy is now est...
Enhancing CAR T-cell therapy manufacturing efficiency through semi-automated bioprocessing [0.03%]
通过半自动生物加工提高CAR-T细胞治疗制造效率
Jason Isaacson,Prajakta Bhanap,Nicholas Putnam et al.
Jason Isaacson et al.
Objectives: Chimeric antigen receptor (CAR) T-cell therapies have revolutionised the treatment of blood-based malignancies. The use of manual CAR T-cell manufacturing methods is one of the challenges that contributes to t...
Loss of CXCR5 expression and monocyte epithelial-mesenchymal transition are blood-borne signatures of sterile granulomatous diseases [0.03%]
CXCR5表达缺失和单核细胞上皮间质转化是无菌肉芽肿性疾病的血液标志物
Yuwei Hao,Anthea Anantharajah,Jane M Wells et al.
Yuwei Hao et al.
Objectives: Sarcoidosis is the exemplar sterile granulomatous disease and can affect any organ system. Tattoo uveitis (TU) resembles sarcoidosis clinically and histologically but is distinguished by the absence of systemi...
Xiaohan Xu,John Saxon,Megan Sioe Fei Soon et al.
Xiaohan Xu et al.
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for investigating paediatric cancers, but individual studies often profile a small number of individuals. It is now the standard practice to upload the scRNA-seq data to data reposit...
Antigen-specific polyfunctional cytotoxic T cells differentiate intraocular from peripheral blood immune responses in posterior uveitis [0.03%]
抗原特异性多功能细胞毒T细胞区别玻璃体和外周血免疫反应在后葡萄膜炎中的作用
Kaiser Alam,Arun Raina,Bibhuprasad Das et al.
Kaiser Alam et al.
Objectives: Peripheral blood is frequently used to study the immune response in human uveitis because of the inaccessibility of ocular tissue samples. To determine whether peripheral blood immune cells accurately reflect ...
Differential reactivity of SARS-CoV-2 S-protein T-cell epitopes in vaccinated versus naturally infected individuals [0.03%]
疫苗接种者与自然感染者的SARS-CoV-2 S蛋白T细胞表位的差异反应性
Daniel J Browne,Pauline Crooks,Corey Smith et al.
Daniel J Browne et al.
Objectives: Vaccine-induced protective immunity against SARS-CoV-2 has proved difficult to sustain. Robust T-cell responses are thought to play an important role, but T-cell responses against the SARS-CoV-2 spike protein ...
Leveraging radiotherapy to improve immunotherapy outcomes: rationale, progress and research priorities [0.03%]
利用放疗改善免疫疗法效果：原理、进展与研究重点
Faith Hartley,Martin Ebert,Alistair M Cook
Faith Hartley
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warr...
Mucosal-associated invariant T cells correlate with myocardial ischaemia and remodelling in coronary artery disease [0.03%]
粘膜相关恒定T细胞与冠状动脉疾病的心肌缺血及重构有关
Jiafu Wang,Song Li,Xianling Zhou et al.
Jiafu Wang et al.
Objectives: Myocardial ischaemia and remodelling are major contributors to the progression and mortality of coronary artery disease (CAD). Previous studies have shown immune cell alterations in CAD patients, but their cha...