Invariant natural killer T-cell neutralization is a possible novel therapy for human eosinophilic esophagitis [0.03%]
invariant natural killer t细胞中和可能是人类嗜酸性食管炎的新型疗法
Madhavi Rayapudi,Priya Rajavelu,Xiang Zhu et al.
Madhavi Rayapudi et al.
Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disorder that needs a potential therapeutic strategy. We earlier showed that iNKT cell-deficient mice are protected from allergen-induced EoE. Therefore, we now tested the...
David E Gyorki,Margaret Callahan,Jedd D Wolchok et al.
David E Gyorki et al.
The strategy of immune modulation for the treatment of cancer is being refined with the introduction of multiple new therapeutic agents into the clinic. Melanoma is a disease where many of these agents have demonstrated efficacy. The mechan...
Steven O&#x;Reilly,Rachel Cant,Marzena Ciechomska et al.
Steven O&#x;Reilly et al.
Interleukin-6 (IL-6) is a classic pro-inflammatory cytokine critical in mounting an effective immune response. It is secreted by a wide array of cell types; however, its effector cells are more restricted, owing to the fact that very few ce...
Maternal and infant infections stimulate a rapid leukocyte response in breastmilk [0.03%]
母体和婴儿感染会加快乳汁中的白细胞反应
Foteini Hassiotou,Anna R Hepworth,Philipp Metzger et al.
Foteini Hassiotou et al.
Breastmilk protects infants against infections; however, specific responses of breastmilk immune factors to different infections of either the mother or the infant are not well understood. Here, we examined the baseline range of breastmilk ...
Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis [0.03%]
细菌脂二肽Lipid 654是多发性硬化症的微生物组相关生物标志物
Vahid Farrokhi,Reza Nemati,Frank C Nichols et al.
Vahid Farrokhi et al.
Multiple sclerosis (MS) is an autoimmune disease of unknown etiology. Infectious agents have been suggested to have a role as environmental factors in MS, but this concept remains controversial. Recently, gastrointestinal commensal bacteria...
Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis [0.03%]
来自过敏性鼻炎的间充质干细胞和T细胞的花粉诱导的抗原呈递
Mauli B Desai,Tatyana Gavrilova,Jianjun Liu et al.
Mauli B Desai et al.
Mesenchymal stem cells (MSCs) are promising cellular suppressor of inflammation. This function of MSCs is partly due to their licensing by inflammatory mediators. In cases with reduced inflammation, MSCs could become immune-enhancer cells. ...
IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma [0.03%]
IL-21调节IV期黑色素瘤患者NKT细胞的活化
Jonathan M Coquet,Kresten Skak,Ian D Davis et al.
Jonathan M Coquet et al.
Interleukin-21 (IL-21) is a common γ-chain cytokine produced by T helper and natural killer T (NKT) cells. It has been shown to regulate the response of various lymphocyte subsets including NK, NKT, T and B cells. Owing to its potent anti-...
Monocyte-derived macrophages do not explain susceptibility to pulmonary non-tuberculous mycobacterial disease [0.03%]
单核细胞源性巨噬细胞不能解释肺非结核分枝杆菌病的易感性
Emma de Jong,Andrew Lim,Grant Waterer et al.
Emma de Jong et al.
Pulmonary infections with non-tuberculous mycobacteria (NTM) affect a subset of older individuals (mostly women) with no known immunological defects. As NTMs are intracellular pathogens, it is important to establish whether NTM disease is a...
A new ICB sister journal focuses on clinical and translational immunology [0.03%]
《免疫》姐妹刊聚焦临床与转化免疫学研究
Gabrielle Belz,Stuart G Tangye,Adrian Liston
Gabrielle Belz