Loss of CXCR5 expression and monocyte epithelial-mesenchymal transition are blood-borne signatures of sterile granulomatous diseases [0.03%]
CXCR5表达缺失和单核细胞上皮间质转化是无菌肉芽肿性疾病的血液标志物
Yuwei Hao,Anthea Anantharajah,Jane M Wells et al.
Yuwei Hao et al.
Objectives: Sarcoidosis is the exemplar sterile granulomatous disease and can affect any organ system. Tattoo uveitis (TU) resembles sarcoidosis clinically and histologically but is distinguished by the absence of systemi...
Xiaohan Xu,John Saxon,Megan Sioe Fei Soon et al.
Xiaohan Xu et al.
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for investigating paediatric cancers, but individual studies often profile a small number of individuals. It is now the standard practice to upload the scRNA-seq data to data reposit...
Antigen-specific polyfunctional cytotoxic T cells differentiate intraocular from peripheral blood immune responses in posterior uveitis [0.03%]
抗原特异性多功能细胞毒T细胞区别玻璃体和外周血免疫反应在后葡萄膜炎中的作用
Kaiser Alam,Arun Raina,Bibhuprasad Das et al.
Kaiser Alam et al.
Objectives: Peripheral blood is frequently used to study the immune response in human uveitis because of the inaccessibility of ocular tissue samples. To determine whether peripheral blood immune cells accurately reflect ...
Differential reactivity of SARS-CoV-2 S-protein T-cell epitopes in vaccinated versus naturally infected individuals [0.03%]
疫苗接种者与自然感染者的SARS-CoV-2 S蛋白T细胞表位的差异反应性
Daniel J Browne,Pauline Crooks,Corey Smith et al.
Daniel J Browne et al.
Objectives: Vaccine-induced protective immunity against SARS-CoV-2 has proved difficult to sustain. Robust T-cell responses are thought to play an important role, but T-cell responses against the SARS-CoV-2 spike protein ...
Leveraging radiotherapy to improve immunotherapy outcomes: rationale, progress and research priorities [0.03%]
利用放疗改善免疫疗法效果：原理、进展与研究重点
Faith Hartley,Martin Ebert,Alistair M Cook
Faith Hartley
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warr...
Mucosal-associated invariant T cells correlate with myocardial ischaemia and remodelling in coronary artery disease [0.03%]
粘膜相关恒定T细胞与冠状动脉疾病的心肌缺血及重构有关
Jiafu Wang,Song Li,Xianling Zhou et al.
Jiafu Wang et al.
Objectives: Myocardial ischaemia and remodelling are major contributors to the progression and mortality of coronary artery disease (CAD). Previous studies have shown immune cell alterations in CAD patients, but their cha...
γδ T cell characterisation in the long term after haematopoietic stem cell transplantation and its impact on CMV control and cGVHD severity [0.03%]
造血干细胞移植后长时间的γδT细胞特征及其对CMV控制和cGVHD严重性的影响
Faisal Alagrafi,Arwen Stikvoort,Ahmed Gaballa et al.
Faisal Alagrafi et al.
Objectives: The clinical outcome after allogeneic haematopoietic stem cell transplantation (aHCT) relies greatly on the efficient recovery of T cells. Several studies have investigated the short-term γδ T cell reconstit...
Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity [0.03%]
血液和气道中树突状细胞的水平和功能降低可预测COVID-19疾病的严重程度
Björn Österberg,Sara Falck-Jones,Sindhu Vangeti et al.
Björn Österberg et al.
Objectives: Monocytes and dendritic cells (DCs) are essential players in the immune response to infections, involved in shaping innate and adaptive immunity. However, a complete understanding of their specific roles in re...
Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients [0.03%]
与急诊科患者脓毒症临床结果相关的不同MAIT细胞表型
Johanna Emgård,Iva Filipovic,Christian Unge et al.
Johanna Emgård et al.
Objectives: Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents...
Lightson Ngashangva,Sunil Martin
Lightson Ngashangva
Despite great strides of progress, at least 60% of the responding patients relapse to CAR therapy across the blood malignancies. Off-tumor toxicity apart from functional deficits, cytopenia and infection are the major unfavourable effect of...