SIRT7 ameliorates Th17/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia [0.03%]
脱琥珀酰化STAT3改善SIRT7介导的Th17/Treg平衡以治疗免疫性血小板减少症
Jiao Ge,Xiaoyan Zhang,Fajuan Tang et al.
Jiao Ge et al.
Objectives: The imbalance of Th17/Treg cells represents a key pathogenic mechanism in immune thrombocytopenia (ITP); however, the underlying regulatory mechanisms remain poorly understood. Dysregulated succinylation has b...
Engineered iPSC-derived natural killer cells: recent innovations in translational innate anti-cancer immunotherapy [0.03%]
工程化的诱导多能干细胞来源的自然杀伤细胞：转化型先天性抗肿瘤免疫治疗的最新创新
Jane Sun,Melissa Elliott,Fernando Souza-Fonseca-Guimaraes
Jane Sun
Natural killer (NK) cells are increasingly recognised as potent tumoricidal agents that can be utilised for cancer immunotherapy. Their innate cytotoxicity against tumor cells, and reduced risk of causing transplantation or toxicity issues ...
Erratum: Data standards for single-cell RNA-sequencing of paediatric cancer [0.03%]
更正：儿科癌症单细胞RNA测序数据标准
[This corrects the article DOI: 10.1002/cti2.70033.]. © 2025 The Author(s). Clinical & Translational Immunology published by John Wiley & Sons Australia...
Published Erratum
Clinical & translational immunology. 2025 Jul 10;14(7):e70044. DOI:10.1002/cti2.70044 2025
The role of immunochemotherapy maintenance in metastatic nasopharyngeal carcinoma: insights from a cohort study in an endemic region [0.03%]
免疫化疗维持治疗在转移性鼻咽癌中的作用：一个地方病区域队列研究的启示
Zhuoying Luo,Yue Xia,Yuping Zhao et al.
Zhuoying Luo et al.
Objectives: Metastatic nasopharyngeal carcinoma (mNPC) following palliative chemotherapy has high incidence and mortality rates. While maintenance therapy shows promising potential, the optimal strategy remains undefined....
Cellular hierarchy for understanding heterogeneity of acute myeloid leukaemia with t(8;21)/RUNX1-RUNX1T1 [0.03%]
阐明t(8;21)/RUNX1-RUNX1T1急性髓系白血病异质性的细胞层级结构
Yibo Wu,Xiaolin Yuan,Xiaoyu Lai et al.
Yibo Wu et al.
Objectives: Differentiation hierarchies in myeloid malignancies influence therapeutic response and prognosis. Acute myeloid leukaemia (AML) with t(8;21) is one of the most recurrent genetic subtypes of AML and is consider...
Long-term immune changes after COVID-19 and the effect of BCG vaccination and latent infections on disease severity [0.03%]
COVID-19后的长期免疫变化以及卡介苗接种和潜伏感染对疾病严重程度的影响
Kamila Bendíčková,Ioanna Papatheodorou,Gabriela Blažková et al.
Kamila Bendíčková et al.
Objectives: Several years after the COVID-19 pandemic, the impact of SARS-CoV-2 on immunity and the potential protective role of Bacillus Calmette-Guérin (BCG) vaccination through trained immunity remain a subject of inv...
Functional characterisation of CD8+ T cells mobilised with acute supramaximal high-intensity interval exercise: implications for immune surveillance [0.03%]
高强度间歇运动调动的CD8⁺T细胞的功能表征及其对免疫监视的意义
Anna Strömberg,Mirko Mandić,Brennan J Wadsworth et al.
Anna Strömberg et al.
Objectives: The beneficial influence of exercise on outcomes such as infection control and cancer prevention has been attributed partly to the immune system response during physical exertion. CD8+ T cells play a crucial r...
Long-lasting changes in circulating dendritic cell and monocyte subsets, and altered expression of EMR2, CD97 and EMR3 on these cells in the posttraumatic course [0.03%]
创伤后循环中树突状细胞和单核细胞亚群的长期变化及其在这些细胞上EMR2、CD97和EMR3表达的改变
Leyu Zheng,Carolin Fuchs,Christian Kleber et al.
Leyu Zheng et al.
Objectives: Traumatic injury triggers the rapid release of damage-associated patterns (DAMPs). Dendritic cells (DCs) and monocytes play key roles in sensing, processing, and presenting DAMPs to naïve T cells. These heter...
Allogeneic 'off-the-shelf' SARS-CoV-2-specific adoptive T-cell therapy for refractory viral infection and end organ disease [0.03%]
针对难治性病毒性感染和靶器官损伤的同种异体“即用型”SARS-CoV-2特异性过继性T细胞治疗
Andrea S Henden,Katie E Lineburg,Archana Panikkar et al.
Andrea S Henden et al.
Objectives: Despite the effective roll-out of COVID-19 vaccines, immunocompromised patients have a higher risk of morbidity and mortality following SARS-CoV-2 infection. Allogeneic adoptive T-cell immunotherapy is now est...
Enhancing CAR T-cell therapy manufacturing efficiency through semi-automated bioprocessing [0.03%]
通过半自动生物加工提高CAR-T细胞治疗制造效率
Jason Isaacson,Prajakta Bhanap,Nicholas Putnam et al.
Jason Isaacson et al.
Objectives: Chimeric antigen receptor (CAR) T-cell therapies have revolutionised the treatment of blood-based malignancies. The use of manual CAR T-cell manufacturing methods is one of the challenges that contributes to t...