A semi-automated ASC speck assay to evaluate pyrin inflammasome activation [0.03%]
一种半自动ASC斑点测定法来评估Pyrin炎症小体激活效应
Pei Dai,Oliver Skinner,Xufeng Lin et al.
Pei Dai et al.
Objective: To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods: Overacti...
Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan [0.03%]
台湾地区全身性关联研究及嗜酸性粒细胞多基因风险评分
Hsing-Fang Lu,Su Boon-Yong,Chi-Ya Yang et al.
Hsing-Fang Lu et al.
Objectives: Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examin...
Single-cell RNA sequencing reveals cell immune status and dysregulated monocytes in patients with myasthenia gravis [0.03%]
单细胞RNA测序揭示重症肌无力患者免疫细胞状态及单核细胞的异常
Yufan Guo,Yu Gu,Yuting Jin et al.
Yufan Guo et al.
Objectives: As an autoimmune disorder, myasthenia gravis (MG) manifests as an autoimmune attack on postsynaptic neuromuscular junction proteins by pathogenic autoantibodies. This immune attack disrupts neurotransmission, ...
Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules [0.03%]
一种流感衍生肽在HLA-B44超型分子中的免疫原性缺失
Samuel Liwei Leong,Janesha C Maddumage,Stephanie Gras et al.
Samuel Liwei Leong et al.
Objectives: CD8+ T cells are protective against influenza and there is an interest in designing a future CD8+ T-cell-mediated vaccine. However, a significant challenge is the extensive polymorphism of Human Leukocyte Anti...
Long-term effects of influenza and Bacille Calmette-Guérin vaccination on systemic inflammation [0.03%]
流感和卡介苗接种对全身炎症的长期影响
Priya A Debisarun,Rutger J Röring,Özlem Bulut et al.
Priya A Debisarun et al.
Objective: Chronic systemic inflammation can lead to metabolic, cardiovascular and neurodegenerative complications, but the factors influencing it are incompletely understood. In this study, we evaluated several factors, ...
Xiaomeng Zhang,Rachel Xu,Dmitry Zorin et al.
Xiaomeng Zhang et al.
Objectives: Chimeric antigen receptor (CAR) T cell therapies have transformed the treatment of B cell malignancies and show promise in other diseases, including autoimmune disorders and cardiac injury. However, broader ap...
High-dimensional flow cytometry reveals lymphocyte subset populations predictive of chronic lung allograft dysfunction [0.03%]
高维流式细胞术可揭示预测慢性肺移植功能障碍的淋巴细胞亚群
Rohia Farighi,Steven Hiho,Thomas Ashhurst et al.
Rohia Farighi et al.
Objectives: Despite cellular and antibody-mediated rejection being clinically relevant drivers of chronic lung allograft dysfunction (CLAD), there are few studies describing the T- and B-cell dynamics inherent to such all...
IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway [0.03%]
IgG通过上调TNFR1及NF-κB信号通路表达促进TNF-α诱导的破骨细胞生成
Haifeng Yin,Yao Teng,Guo-Min Deng
Haifeng Yin
Objectives: Tumor necrosis factor-α (TNF-α) plays a pivotal role in bone damage associated with inflammatory arthritis such as rheumatoid arthritis (RA). Both systemic lupus erythematosus (SLE) and rheumatoid arthritis ...
Elucidating novel immune profiles for predicting infection in high-risk cohorts: a pilot study in patients with relapsed and refractory chronic lymphocytic leukaemia [0.03%]
阐明新型免疫谱型以预测高危患者感染的前瞻性研究：复发和难治性慢性淋巴细胞白血病患者的初步研究报告
Lewis J Williams,Connie Sn Li-Wai-Suen,Alex L Garnham et al.
Lewis J Williams et al.
Objectives: Chronic lymphocytic leukaemia (CLL) patients are at increased risk for infection, with the risk even higher for relapsed and refractory patients. Clinical assessment of infection risk is increasingly challengi...
SIRT7 ameliorates Th17/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia [0.03%]
脱琥珀酰化STAT3改善SIRT7介导的Th17/Treg平衡以治疗免疫性血小板减少症
Jiao Ge,Xiaoyan Zhang,Fajuan Tang et al.
Jiao Ge et al.
Objectives: The imbalance of Th17/Treg cells represents a key pathogenic mechanism in immune thrombocytopenia (ITP); however, the underlying regulatory mechanisms remain poorly understood. Dysregulated succinylation has b...