Elevated high-density lipoprotein levels following acute graft-versus-host disease onset: a potential link to T-cell dysfunction and increased relapse risk [0.03%]
急性移植物抗宿主病发作后高密度脂蛋白水平升高：与T细胞功能障碍和复发风险增加的潜在联系
Romy Böttcher-Loschinski,Franziska Karl,Diana Drettwan et al.
Romy Böttcher-Loschinski et al.
Objectives: Allogeneic stem cell transplantation (allo-SCT) is the only curative treatment option for several haematologic malignancies. Its therapeutic principle is based on the donor T cells' ability to eliminate any re...
Divyaa Narayanan,Seen Ling Sim,Snehlata Kumari
Divyaa Narayanan
The skin is a vital organ that protects organisms from external insults, providing a barrier to the outside environment. The cellular system of the skin consists of highly specialised immune and non-immune cells, which are equipped to respo...
Yuxi Chen,Hengmo Rong,Ting Li et al.
Yuxi Chen et al.
Pneumocystis pneumonia (PCP), caused by the opportunistic fungal pathogen Pneumocystis, remains a common fungal infection among immunosuppressed individuals. T cells are known to play a critical role in host defences against Pneumocystis. T...
Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre-clinical models [0.03%]
靶向肝内胆管癌肿瘤微环境以改善免疫检查点抑制：潜在策略和转化前期模型
Maria-Danae Jessel,Owen McGreevy,Lauryn McReynolds et al.
Maria-Danae Jessel et al.
Cholangiocarcinoma is a malignancy of significant unmet clinical need with limited therapeutic options. Most patients are diagnosed at advanced or metastatic stages, where surgical resection with curative intent is no longer an option. Gemc...
Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination [0.03%]
季节性流感疫苗接种可改变人类腋窝淋巴结T滤泡辅助细胞(TFH)和前体-TFH细胞的功能灵活性
Hannah Law,Raymond H Y Louie,Omid R Faridani et al.
Hannah Law et al.
Objectives: CD4+ T cells partitioned into different cell lineages based on transcription factor, cytokine and chemokine expression have defined functions that work cooperatively to ensure optimum operation of the immune s...
A semi-automated ASC speck assay to evaluate pyrin inflammasome activation [0.03%]
一种半自动ASC斑点测定法来评估Pyrin炎症小体激活效应
Pei Dai,Oliver Skinner,Xufeng Lin et al.
Pei Dai et al.
Objective: To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods: Overacti...
Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan [0.03%]
台湾地区全身性关联研究及嗜酸性粒细胞多基因风险评分
Hsing-Fang Lu,Su Boon-Yong,Chi-Ya Yang et al.
Hsing-Fang Lu et al.
Objectives: Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examin...
Single-cell RNA sequencing reveals cell immune status and dysregulated monocytes in patients with myasthenia gravis [0.03%]
单细胞RNA测序揭示重症肌无力患者免疫细胞状态及单核细胞的异常
Yufan Guo,Yu Gu,Yuting Jin et al.
Yufan Guo et al.
Objectives: As an autoimmune disorder, myasthenia gravis (MG) manifests as an autoimmune attack on postsynaptic neuromuscular junction proteins by pathogenic autoantibodies. This immune attack disrupts neurotransmission, ...
Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules [0.03%]
一种流感衍生肽在HLA-B44超型分子中的免疫原性缺失
Samuel Liwei Leong,Janesha C Maddumage,Stephanie Gras et al.
Samuel Liwei Leong et al.
Objectives: CD8+ T cells are protective against influenza and there is an interest in designing a future CD8+ T-cell-mediated vaccine. However, a significant challenge is the extensive polymorphism of Human Leukocyte Anti...
Long-term effects of influenza and Bacille Calmette-Guérin vaccination on systemic inflammation [0.03%]
流感和卡介苗接种对全身炎症的长期影响
Priya A Debisarun,Rutger J Röring,Özlem Bulut et al.
Priya A Debisarun et al.
Objective: Chronic systemic inflammation can lead to metabolic, cardiovascular and neurodegenerative complications, but the factors influencing it are incompletely understood. In this study, we evaluated several factors, ...