Shared donor-recipient γδ T-cell phenotypic and repertoire features associate with cytomegalovirus reactivation after allogeneic haematopoietic stem cell transplantation [0.03%]
同种异体造血干细胞移植后巨细胞病毒再激活与共享的供受者γδT细胞表型和谱系特征相关性研究
Paula Hahn,Arwen Stikvoort,Faisal Alagrafi et al.
Paula Hahn et al.
Allogeneic haematopoietic stem cell transplantation (HSCT) is the only curative therapy for patients diagnosed with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). γδ+ T-cells, a rare subpopulation of T-cells with both i...
Elevated plasma CXCL9 and CHI3L1 prior to HCT predict post-HCT lung complications in children [0.03%]
儿童造血干细胞移植前后血浆CXCL9和CHI3L1水平升高与肺部并发症的关系
Hannah Walker,Liam Gubbels,Gabrielle M Haeusler et al.
Hannah Walker et al.
Objectives: Lung complications occur commonly post-haematopoietic stem cell transplant (HCT) in children and contribute significantly to mortality. The development of biomarkers predictive of post-HCT lung complications m...
Nalmefene enhances the remyelinating ability of nalfurafine when administered therapeutically at very low doses during experimental autoimmune encephalomyelitis [0.03%]
纳拉菲林在实验性自身免疫性脑脊髓炎中以非常低的剂量治疗时可增强纳拉美芬的促进脱髓鞘修复作用
Lisa Denny,Katharina Robichon,Nikki Templeton et al.
Lisa Denny et al.
Objectives: Multiple sclerosis is an immune-mediated inflammatory disease of the central nervous system. Recently, kappa opioid receptor (KOR) agonists were found to promote remyelination and recovery in models of demyeli...
Low-level human memory T and B cells recognising avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines [0.03%]
现有的季节性流感疫苗对低水平的人记忆T和B细胞识别禽流感血凝素的反应较差
Christopher A Gonelli,Marios Koutsakos,Robyn Esterbauer et al.
Christopher A Gonelli et al.
Objectives: Immunisation remains the most cost-effective mechanism to combat influenza infection and is widely employed against seasonal influenza viruses. Zoonotic transmission of avian influenza A viruses represents a s...
An optimised whole blood interleukin-2 release assay is more sensitive than interferon-γ ELISpot for detecting and quantifying gluten-specific CD4+ T-cell responses in coeliac disease [0.03%]
一种优化的全血白细胞介素-2释放检测法可更灵敏地用于检测和量化乳糜泻中的 Gluten 特异性CD4+T细胞反应，优于干扰素-γ ELISpot 检测法
Olivia G Moscatelli,Amy K Russell,Lee M Henneken et al.
Olivia G Moscatelli et al.
Objectives: Detection of antigen-specific T cells has been crucial for the study of autoimmune illnesses such as coeliac disease (CD). In CD, an oral gluten challenge is required to expand the rare population of circulati...
Coexistence of SAPHO syndrome and IgG4-related disease with Upadacitinib [0.03%]
乌帕替尼联合治疗SAPHO综合征和IgG4相关性疾病病例报告
Hang Zhou,Xin Zhao,Ru Chen et al.
Hang Zhou et al.
Objectives: To describe the first reported case of coexisting Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome and IgG4-related disease (IgG4-RD) and to evaluate the therapeutic response to Upadaci...
Immediate variations in high-dimensional circulating immune cells following pancreatectomy [0.03%]
胰腺切除术后循环免疫细胞的高维度瞬时变化
Jonathan Garnier,Anaïs Palen,Xavier Durand et al.
Jonathan Garnier et al.
Objectives: Despite advancements in surgical techniques and perioperative care, pancreatic surgery remains a high-risk procedure with significant morbidity and mortality. Furthermore, understanding its impact on the immun...
Adeno-associated viral vectors encoding anti-P2X7 nanobodies reduce graft-versus-host disease in a humanised mouse model [0.03%]
人源化小鼠模型中，编码抗P2X7纳米抗体的腺相关病毒载体可降低移植物抗宿主病
Amal Elhage,Janna H Hadaya,Chloe Sligar et al.
Amal Elhage et al.
Objectives: Graft-versus-host disease (GVHD) is an inflammatory disorder that arises following allogeneic haematopoietic stem cell transplantation. P2X7 is an extracellular ATP-gated cation channel present on immune cells...
Genetic differences in the HLA region contribute to the variability in SARS-CoV-2 vaccine responsiveness of older persons: the Doetinchem Cohort Study [0.03%]
基因差异对老年人SARS-CoV-2疫苗反应性的贡献：Doetinchem队列研究
Yunus Kuijpers,M Liset Rietman,H Susan J Picavet et al.
Yunus Kuijpers et al.
Objectives: Older persons generally have weaker antibody responses to vaccines than younger individuals, but heterogeneity is large. We aimed to identify genetic variants associated with primary SARS-CoV-2 vaccine-induced...
High-dimensional spectral cytometry identifies follicular regulatory CD8+ T cells in diffuse large B-cell lymphoma [0.03%]
高维光谱细胞计数鉴定弥漫性大B细胞淋巴瘤中的生发中心调节CD8+T细胞
Alba Díaz Herrero,Phuong-Ha Le,Loic Renaud et al.
Alba Díaz Herrero et al.
Objectives: Diffuse large B-cell lymphoma (DLBCL) constitutes 30-40% of non-Hodgkin lymphoma cases. Despite therapeutic advances, persistence of relapsed cases has been linked to the complex tumor microenvironment (TME) a...