Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut-brain endothelial dysfunction [0.03%]
遗传性干扰素病患者的脑脊液中鉴定肠道代谢产物支持肠-脑内皮功能障碍理论
Russell C Dale,Madysen Elbourne,Markus J Hofer et al.
Russell C Dale et al.
Objective: Aicardi-Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti-viral (interferon) activation. This metabolomics study aimed to improve th...
The impact of B-cell reconstitution on mRNA vaccine responses in allogeneic stem cell transplant recipients [0.03%]
同种异体干细胞移植受者中B细胞重建对mRNA疫苗反应的影响
Fredrika Hellgren,Rodrigo Arcoverde Cerveira,Gustaf Lindgren et al.
Fredrika Hellgren et al.
Objectives: Vaccine responses in haematopoietic stem cell transplant (alloHCT) recipients vary, with different degrees of B-cell reconstitution likely playing a key role. However, mechanistic understanding of the B-cell r...
CD56brightNK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B-cell-depleting therapy [0.03%]
BCMA疗法增强多发性硬化症患者对疫苗的抗体反应
Griffith B Perkins,Christopher M Hope,Cheng Sheng Chai et al.
Griffith B Perkins et al.
Objectives: We sought to identify determinants of vaccine response in people with multiple sclerosis (pwMS) receiving B-cell-depleting therapies. Methods:...
Integrating mass spectrometry-based multi-omic signatures of extracellular vesicles: from discovery to clinical translation [0.03%]
基于质谱的外泌体多组学标志物的整合：从发现到临床应用
Akila Wijerathna-Yapa,Dimitri Aubert,Arutha Kulasinghe
Akila Wijerathna-Yapa
Extracellular vesicles (EVs) are increasingly recognised as key mediators of intercellular communication and disease progression. Their capacity to carry bioactive molecules, namely proteins, lipids and metabolites, reflects the physiologic...
A novel surface plasmon resonance approach to assess anti-dsDNA antibody kinetics and disease severity in systemic lupus erythematosus [0.03%]
一种新的表面等离子体共振方法评估系统性红斑狼疮中抗dsdna抗体动力学和疾病严重程度
Carole Nagant,Maxime Taghavi,Hasnae Ben Kacem Ziani et al.
Carole Nagant et al.
Objectives: Anti-dsDNA antibodies are established biomarkers in systemic lupus erythematosus (SLE), yet the clinical utility of conventional assays remains limited by variable analytical performance. We evaluated a novel ...
Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models [0.03%]
人多能干细胞来源的巨噬细胞在结核病感染模型中的免疫激活和反应动力学
Daniela Paasch,Hannah Schevel,Andrea Riehle et al.
Daniela Paasch et al.
Objectives: Tuberculosis (TB) remains a global health challenge, with current antibiotic therapies being limited by long treatments, side effects and multidrug-resistant mycobacterial strains. In addition, Mycobacterium t...
A comprehensive analysis of the correlation between plasma cytokines/chemokines and tumor immune microenvironment signature influences the response of checkpoint inhibitors in advanced non-small-cell lung cancer [0.03%]
血浆细胞因子/趋化因子与肿瘤免疫微环境特征对晚期非小细胞肺癌患者免疫检查点抑制剂疗效的影响及相关性分析
Van Hieu Mai,Marisa Prasanpanich,Nicha Zungsontiporn et al.
Van Hieu Mai et al.
Objectives: Circulating cytokines/chemokines are linked to checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC). The tumor-immune microenvironment (TIME) plays a significant role in modulating a broad range ...
Dissecting infant and maternal antibody repertoires exposes the early onset of infant humoral immunity [0.03%]
分析婴儿和母体抗体 repertoire 可揭示婴儿体液免疫的早期发生时间
Albert Bondt,Minjie Tan,Kelly A Dingess et al.
Albert Bondt et al.
Objectives: The early development of humoral immunity is important for long-term protection of the newborn. Here, we set out to discern these infant-produced antibodies from the vast background of maternal antibodies, whi...
Prolonged persistence of tissue-resident memory cells in the upper airway following SARS-CoV-2 infection and vaccination [0.03%]
感染新冠病毒及接种疫苗后上呼吸道组织驻留记忆细胞的持续存在
Hyunkyung Cha,Jina Won,Soo Min Kim et al.
Hyunkyung Cha et al.
Objectives: Here, we characterised the diversity and persistence of immunological memory cells-particularly tissue-resident memory T (TRM) and B (BRM) cells-in the nasopharyngeal lymphoid tissues of healthy vaccinated (HV...
Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID-19 [0.03%]
功能多样的T辅助细胞与COVID-19后抗体反应的大小和持久性相关
Katie Tungatt,Gabriela Martins Costa Gomes,Nicole L Fewings et al.
Katie Tungatt et al.
Objective: Examine the role of T cells in shaping and sustaining humoral immunity to SARS-CoV-2 and identify immune factors associated with durable antibody responses. ...