An optimised whole blood interleukin-2 release assay is more sensitive than interferon-γ ELISpot for detecting and quantifying gluten-specific CD4+ T-cell responses in coeliac disease [0.03%]
一种优化的全血白细胞介素-2释放检测法可更灵敏地用于检测和量化乳糜泻中的 Gluten 特异性CD4+T细胞反应，优于干扰素-γ ELISpot 检测法
Olivia G Moscatelli,Amy K Russell,Lee M Henneken et al.
Olivia G Moscatelli et al.
Objectives: Detection of antigen-specific T cells has been crucial for the study of autoimmune illnesses such as coeliac disease (CD). In CD, an oral gluten challenge is required to expand the rare population of circulati...
Coexistence of SAPHO syndrome and IgG4-related disease with Upadacitinib [0.03%]
乌帕替尼联合治疗SAPHO综合征和IgG4相关性疾病病例报告
Hang Zhou,Xin Zhao,Ru Chen et al.
Hang Zhou et al.
Objectives: To describe the first reported case of coexisting Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome and IgG4-related disease (IgG4-RD) and to evaluate the therapeutic response to Upadaci...
Immediate variations in high-dimensional circulating immune cells following pancreatectomy [0.03%]
胰腺切除术后循环免疫细胞的高维度瞬时变化
Jonathan Garnier,Anaïs Palen,Xavier Durand et al.
Jonathan Garnier et al.
Objectives: Despite advancements in surgical techniques and perioperative care, pancreatic surgery remains a high-risk procedure with significant morbidity and mortality. Furthermore, understanding its impact on the immun...
Adeno-associated viral vectors encoding anti-P2X7 nanobodies reduce graft-versus-host disease in a humanised mouse model [0.03%]
人源化小鼠模型中，编码抗P2X7纳米抗体的腺相关病毒载体可降低移植物抗宿主病
Amal Elhage,Janna H Hadaya,Chloe Sligar et al.
Amal Elhage et al.
Objectives: Graft-versus-host disease (GVHD) is an inflammatory disorder that arises following allogeneic haematopoietic stem cell transplantation. P2X7 is an extracellular ATP-gated cation channel present on immune cells...
Genetic differences in the HLA region contribute to the variability in SARS-CoV-2 vaccine responsiveness of older persons: the Doetinchem Cohort Study [0.03%]
基因差异对老年人SARS-CoV-2疫苗反应性的贡献：Doetinchem队列研究
Yunus Kuijpers,M Liset Rietman,H Susan J Picavet et al.
Yunus Kuijpers et al.
Objectives: Older persons generally have weaker antibody responses to vaccines than younger individuals, but heterogeneity is large. We aimed to identify genetic variants associated with primary SARS-CoV-2 vaccine-induced...
High-dimensional spectral cytometry identifies follicular regulatory CD8+ T cells in diffuse large B-cell lymphoma [0.03%]
高维光谱细胞计数鉴定弥漫性大B细胞淋巴瘤中的生发中心调节CD8+T细胞
Alba Díaz Herrero,Phuong-Ha Le,Loic Renaud et al.
Alba Díaz Herrero et al.
Objectives: Diffuse large B-cell lymphoma (DLBCL) constitutes 30-40% of non-Hodgkin lymphoma cases. Despite therapeutic advances, persistence of relapsed cases has been linked to the complex tumor microenvironment (TME) a...
Elevated high-density lipoprotein levels following acute graft-versus-host disease onset: a potential link to T-cell dysfunction and increased relapse risk [0.03%]
急性移植物抗宿主病发作后高密度脂蛋白水平升高：与T细胞功能障碍和复发风险增加的潜在联系
Romy Böttcher-Loschinski,Franziska Karl,Diana Drettwan et al.
Romy Böttcher-Loschinski et al.
Objectives: Allogeneic stem cell transplantation (allo-SCT) is the only curative treatment option for several haematologic malignancies. Its therapeutic principle is based on the donor T cells' ability to eliminate any re...
Divyaa Narayanan,Seen Ling Sim,Snehlata Kumari
Divyaa Narayanan
The skin is a vital organ that protects organisms from external insults, providing a barrier to the outside environment. The cellular system of the skin consists of highly specialised immune and non-immune cells, which are equipped to respo...
Yuxi Chen,Hengmo Rong,Ting Li et al.
Yuxi Chen et al.
Pneumocystis pneumonia (PCP), caused by the opportunistic fungal pathogen Pneumocystis, remains a common fungal infection among immunosuppressed individuals. T cells are known to play a critical role in host defences against Pneumocystis. T...
Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre-clinical models [0.03%]
靶向肝内胆管癌肿瘤微环境以改善免疫检查点抑制：潜在策略和转化前期模型
Maria-Danae Jessel,Owen McGreevy,Lauryn McReynolds et al.
Maria-Danae Jessel et al.
Cholangiocarcinoma is a malignancy of significant unmet clinical need with limited therapeutic options. Most patients are diagnosed at advanced or metastatic stages, where surgical resection with curative intent is no longer an option. Gemc...