A novel surface plasmon resonance approach to assess anti-dsDNA antibody kinetics and disease severity in systemic lupus erythematosus [0.03%]
一种新的表面等离子体共振方法评估系统性红斑狼疮中抗dsdna抗体动力学和疾病严重程度
Carole Nagant,Maxime Taghavi,Hasnae Ben Kacem Ziani et al.
Carole Nagant et al.
Objectives: Anti-dsDNA antibodies are established biomarkers in systemic lupus erythematosus (SLE), yet the clinical utility of conventional assays remains limited by variable analytical performance. We evaluated a novel ...
Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models [0.03%]
人多能干细胞来源的巨噬细胞在结核病感染模型中的免疫激活和反应动力学
Daniela Paasch,Hannah Schevel,Andrea Riehle et al.
Daniela Paasch et al.
Objectives: Tuberculosis (TB) remains a global health challenge, with current antibiotic therapies being limited by long treatments, side effects and multidrug-resistant mycobacterial strains. In addition, Mycobacterium t...
A comprehensive analysis of the correlation between plasma cytokines/chemokines and tumor immune microenvironment signature influences the response of checkpoint inhibitors in advanced non-small-cell lung cancer [0.03%]
血浆细胞因子/趋化因子与肿瘤免疫微环境特征对晚期非小细胞肺癌患者免疫检查点抑制剂疗效的影响及相关性分析
Van Hieu Mai,Marisa Prasanpanich,Nicha Zungsontiporn et al.
Van Hieu Mai et al.
Objectives: Circulating cytokines/chemokines are linked to checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC). The tumor-immune microenvironment (TIME) plays a significant role in modulating a broad range ...
Dissecting infant and maternal antibody repertoires exposes the early onset of infant humoral immunity [0.03%]
分析婴儿和母体抗体 repertoire 可揭示婴儿体液免疫的早期发生时间
Albert Bondt,Minjie Tan,Kelly A Dingess et al.
Albert Bondt et al.
Objectives: The early development of humoral immunity is important for long-term protection of the newborn. Here, we set out to discern these infant-produced antibodies from the vast background of maternal antibodies, whi...
Prolonged persistence of tissue-resident memory cells in the upper airway following SARS-CoV-2 infection and vaccination [0.03%]
感染新冠病毒及接种疫苗后上呼吸道组织驻留记忆细胞的持续存在
Hyunkyung Cha,Jina Won,Soo Min Kim et al.
Hyunkyung Cha et al.
Objectives: Here, we characterised the diversity and persistence of immunological memory cells-particularly tissue-resident memory T (TRM) and B (BRM) cells-in the nasopharyngeal lymphoid tissues of healthy vaccinated (HV...
Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID-19 [0.03%]
功能多样的T辅助细胞与COVID-19后抗体反应的大小和持久性相关
Katie Tungatt,Gabriela Martins Costa Gomes,Nicole L Fewings et al.
Katie Tungatt et al.
Objective: Examine the role of T cells in shaping and sustaining humoral immunity to SARS-CoV-2 and identify immune factors associated with durable antibody responses. ...
Shared donor-recipient γδ T-cell phenotypic and repertoire features associate with cytomegalovirus reactivation after allogeneic haematopoietic stem cell transplantation [0.03%]
同种异体造血干细胞移植后巨细胞病毒再激活与共享的供受者γδT细胞表型和谱系特征相关性研究
Paula Hahn,Arwen Stikvoort,Faisal Alagrafi et al.
Paula Hahn et al.
Allogeneic haematopoietic stem cell transplantation (HSCT) is the only curative therapy for patients diagnosed with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). γδ+ T-cells, a rare subpopulation of T-cells with both i...
Elevated plasma CXCL9 and CHI3L1 prior to HCT predict post-HCT lung complications in children [0.03%]
儿童造血干细胞移植前后血浆CXCL9和CHI3L1水平升高与肺部并发症的关系
Hannah Walker,Liam Gubbels,Gabrielle M Haeusler et al.
Hannah Walker et al.
Objectives: Lung complications occur commonly post-haematopoietic stem cell transplant (HCT) in children and contribute significantly to mortality. The development of biomarkers predictive of post-HCT lung complications m...
Nalmefene enhances the remyelinating ability of nalfurafine when administered therapeutically at very low doses during experimental autoimmune encephalomyelitis [0.03%]
纳拉菲林在实验性自身免疫性脑脊髓炎中以非常低的剂量治疗时可增强纳拉美芬的促进脱髓鞘修复作用
Lisa Denny,Katharina Robichon,Nikki Templeton et al.
Lisa Denny et al.
Objectives: Multiple sclerosis is an immune-mediated inflammatory disease of the central nervous system. Recently, kappa opioid receptor (KOR) agonists were found to promote remyelination and recovery in models of demyeli...
Low-level human memory T and B cells recognising avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines [0.03%]
现有的季节性流感疫苗对低水平的人记忆T和B细胞识别禽流感血凝素的反应较差
Christopher A Gonelli,Marios Koutsakos,Robyn Esterbauer et al.
Christopher A Gonelli et al.
Objectives: Immunisation remains the most cost-effective mechanism to combat influenza infection and is widely employed against seasonal influenza viruses. Zoonotic transmission of avian influenza A viruses represents a s...