Neutralising antibody responses to emerging SARS-CoV-2 omicron sub-variants are enhanced in persons with hybrid immunity [0.03%]
具有杂交免疫的人对抗新出现的SARS-CoV-2奥密克戎亚变体的中和抗体反应更强
Sharon L Walmsley,Majid Nabipoor,Freda Qi et al.
Sharon L Walmsley et al.
Objectives: To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods: We explored SARS-CoV-2 neutralizing ant...
Fatty acid metabolism-an emerging regulatory node in T-cell immunometabolism [0.03%]
脂肪酸代谢-T细胞免疫代谢中的一个新兴调控节点
Brett Chapel Arenberg,Michael N Sack,Jing Wu
Brett Chapel Arenberg
While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowle...
Hao Nguyen,Merrin Mary Eapen,Quan Nguyen et al.
Hao Nguyen et al.
Spatial transcriptomics (ST) and spatial proteomics (SP) have revolutionised our ability to map RNA and protein distributions within intact tissues, shedding new light on the dynamic interactions that drive physiological processes in health...
A characterisation of the immune cells in immunocompetent and immunodeficient mice with orthotopic brain tumors [0.03%]
免疫功能正常和缺陷的小鼠原位脑肿瘤的免疫细胞特征分析
Bryan Gardam,Eunwoo Nam,Paris M Kollis et al.
Bryan Gardam et al.
Objectives: Glioblastoma is characterised by poor survival with few treatment advances for over 20 years. Immunotherapies, which have transformed treatment of other cancers, have been difficult to apply to glioblastoma be...
Influenza virus infection drives upregulation of CD84 across a broad range of immune cells [0.03%]
流感病毒感驱动免疫细胞中CD84的上调表达
Xiaoxiao Jia,Isabelle Jh Foo,Hayley A McQuilten et al.
Xiaoxiao Jia et al.
Objectives: Our previous study in hospitalised patients infected with avian A(H7N9) influenza virus identified CD84 amongst several genes associated with recovery. Yet, the correlation between CD84 and respiratory viral i...
Integrated humoral and inflammatory signatures predict outcomes in severe COVID-19: a 14-day longitudinal analysis [0.03%]
整合的体液和炎症标志物可以预测重度新冠肺炎患者的预后：一项为期14天的纵向分析
Hiochelson Najibe Santos Ibiapina,Fabio Magalhães-Gama,Juliana Costa Ferreira Neves et al.
Hiochelson Najibe Santos Ibiapina et al.
Background: Severe COVID-19 is marked by profound immune dysregulation, yet the interplay between humoral and inflammatory responses that determines clinical outcomes in critically ill patients remains incompletely unders...
Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut-brain endothelial dysfunction [0.03%]
遗传性干扰素病患者的脑脊液中鉴定肠道代谢产物支持肠-脑内皮功能障碍理论
Russell C Dale,Madysen Elbourne,Markus J Hofer et al.
Russell C Dale et al.
Objective: Aicardi-Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti-viral (interferon) activation. This metabolomics study aimed to improve th...
The impact of B-cell reconstitution on mRNA vaccine responses in allogeneic stem cell transplant recipients [0.03%]
同种异体干细胞移植受者中B细胞重建对mRNA疫苗反应的影响
Fredrika Hellgren,Rodrigo Arcoverde Cerveira,Gustaf Lindgren et al.
Fredrika Hellgren et al.
Objectives: Vaccine responses in haematopoietic stem cell transplant (alloHCT) recipients vary, with different degrees of B-cell reconstitution likely playing a key role. However, mechanistic understanding of the B-cell r...
CD56brightNK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B-cell-depleting therapy [0.03%]
BCMA疗法增强多发性硬化症患者对疫苗的抗体反应
Griffith B Perkins,Christopher M Hope,Cheng Sheng Chai et al.
Griffith B Perkins et al.
Objectives: We sought to identify determinants of vaccine response in people with multiple sclerosis (pwMS) receiving B-cell-depleting therapies. Methods:...
Integrating mass spectrometry-based multi-omic signatures of extracellular vesicles: from discovery to clinical translation [0.03%]
基于质谱的外泌体多组学标志物的整合：从发现到临床应用
Akila Wijerathna-Yapa,Dimitri Aubert,Arutha Kulasinghe
Akila Wijerathna-Yapa
Extracellular vesicles (EVs) are increasingly recognised as key mediators of intercellular communication and disease progression. Their capacity to carry bioactive molecules, namely proteins, lipids and metabolites, reflects the physiologic...