Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals [0.03%]
活化方案的选择影响CAR-T产品的产量和质量，尤其是老年人群中
Palak H Mehta,Gemma S Trollope,Patrick Leung et al.
Palak H Mehta et al.
Objectives: In clinical chimeric antigen receptor (CAR) T cell therapy, one of the strongest correlates of favorable patient responses is lower levels of differentiation in T cells from the peripheral blood mononuclear ce...
CD8+ T cell epitope conservation in emerging H5N1 viruses suggests global protection [0.03%]
新兴H5N1病毒的CD8+t细胞表位保守性提示其可能提供全球保护作用
Emma J Grant,Stephanie Gras
Emma J Grant
Objectives: The recent H5N1 avian influenza outbreak in the USA has sparked fresh fears of avian viruses causing the next pandemic. To date, the H5N1 (clade 2.3.4.4b) outbreak in cattle has spread across several states in...
Dual CD47 and PD-L1 blockade elicits anti-tumor immunity by intratumoral CD8+ T cells [0.03%]
CD47和PD-L1双阻滞通过瘤内CD8+t细胞发挥抗肿瘤免疫作用
Susan N Christo,Keely M McDonald,Thomas N Burn et al.
Susan N Christo et al.
Objectives: Bispecific antibodies targeting CD47 and PD-L1 (CD47 × PD-L1 BisAb) demonstrate efficacy against a range of solid cancers. While dual blockade negates anti-CD47-mediated toxicity, the effect of combined innat...
The contribution of the CRP/CD64 axis to renal cancer progression by inducing protumor activation of tumor-associated macrophages [0.03%]
CRP/CD64轴通过诱导肿瘤相关巨噬细胞的促肿瘤活化促进肾癌进展
Cheng Pan,Yukio Fujiwara,Hiromu Yano et al.
Cheng Pan et al.
Objectives: C-reactive protein (CRP) is a well-known acute-phase protein that increases remarkably under various inflammatory conditions and is elevated in patients with malignant tumors. In this study, we investigated th...
Autologous Epstein-Barr virus-specific adoptive T-cell therapy in a patient with lupus nephritis [0.03%]
自身Epstein-Barr病毒特异性过继T细胞治疗系统性红斑狼疮伴发的狼疮性肾炎患者
Dwarakanathan Ranganathan,Saskia Leibowitz,George T John et al.
Dwarakanathan Ranganathan et al.
Objectives: Dysregulation of Epstein-Barr virus (EBV)-specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a maj...
Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission [0.03%]
天然杀伤细胞的抗体依赖性细胞毒性受细胞表型、红细胞多态性、寄生虫多样性和传播强度的影响
Stephen Tukwasibwe,Savannah Nicole Lewis,Yoweri Taremwa et al.
Stephen Tukwasibwe et al.
Objectives: Natural killer (NK) cells make important contributions to anti-malarial immunity through antibody-dependent cellular cytotoxicity (ADCC), but the role of different components of this pathway in promoting NK ce...
Inhibitory effect of hydroxychloroquine on glucocorticoid-induced osteoporosis in lupus therapy [0.03%]
羟氯喹对狼疮治疗中糖皮质激素所致骨质疏松的抑制作用
Wenlin Qiu,Xiaoxiao Han,Tong Yu et al.
Wenlin Qiu et al.
Objectives: Systemic lupus erythematosus (SLE) is a chronic and severe autoimmune disease characterised by persistent inflammation. Hydroxychloroquine (HCQ) and glucocorticoids (GCs) are the primary agents commonly used i...
IL-15-induced CD38+HLA-DR+CD8+ T cells correlate with liver injury via NKG2D in chronic hepatitis B cirrhosis [0.03%]
慢性乙型肝炎肝硬化患者中IL-15诱导的CD38+HLA-DR+CD8+T细胞通过NKG2D与肝脏损伤相关
Jing Fan,Min Xu,Ke Liu et al.
Jing Fan et al.
Objectives: CD8+ T cells play a critical role in the immune dysfunction associated with liver cirrhosis. CD38+HLA-DR+CD8+ T cells, or bystander-activated CD8+ T cells, are involved in tissue injury but their specific cont...
Naturally acquired adaptive immunity to Streptococcus pneumoniae is impaired in rheumatoid arthritis patients [0.03%]
类风湿关节炎患者的自然获得性肺炎链球菌适应性免疫受损
Giuseppe Ercoli,Hugh Selway-Clarke,Dena Truijen et al.
Giuseppe Ercoli et al.
Objectives: Patients with rheumatoid arthritis (RA) have an increased susceptibility to infections, including those caused by Streptococcus pneumoniae. Why RA is associated with increased susceptibility to S. pneumoniae i...
Lymphocyte activation gene 3 served as a potential prognostic and immunological biomarker across various cancer types: a clinical and pan-cancer analysis [0.03%]
淋巴细胞活化基因3可作为多种癌症类型中的潜在预后和免疫学生物标志物：临床及泛癌分析
Yifan Liu,Yuntao Yao,Xinyue Yang et al.
Yifan Liu et al.
Objectives: Lymphocyte activation gene 3 (LAG3), an inhibitory receptor in T-cell activation, is a negative prognostic factor. However, its impact on tumours has yet to be comprehensively elucidated on a pan-cancer scale....