Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant [0.03%]
造血干细胞移植后预测和诊断儿童肺部并发症的生物标志物
Hannah Walker,Gabrielle M Haeusler,Theresa Cole et al.
Hannah Walker et al.
Objectives: Haematopoietic cell transplant (HCT) is a cellular therapy for a group of high-risk children with cancer, immunodeficiency and metabolic disorders. Whilst curative for a child's underlying condition, HCT has s...
Pulmonary complications post allogeneic haematopoietic stem cell transplant in children [0.03%]
儿童造血干细胞移植后的肺部并发症
Hannah Walker,Joanne Abbotsford,Gabrielle M Haeusler et al.
Hannah Walker et al.
Objectives: Haematopoietic stem cell transplant (HCT) is a cellular therapy that, whilst curative for a child's underlying disease, carries significant risk of mortality, including because of pulmonary complications. The ...
The Omega-6 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic fibrosis lung disease [0.03%]
脂质途径六价碳氮结构与早期囊性纤维化肺病相关的研究
Lisa Jm Slimmen,Jelle Y Broos,Badies Han Manaï et al.
Lisa Jm Slimmen et al.
Objectives: In cystic fibrosis (CF), an imbalanced lipid metabolism is associated with lung inflammation. Little is known about the role that specific lipid mediators (LMs) exert in CF lung inflammation, and whether their...
Siglec-7 and Siglec-9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling [0.03%]
原发性三阴性和雌激素受体阳性乳腺癌及其信号转导中的Siglec-7和Siglec-9表达
Eline Jh van Houtum,Anne Hc Valk,Daniel Granado et al.
Eline Jh van Houtum et al.
Objectives: PD-1/PD-L1 immune checkpoint blockade can be an effective treatment for advanced breast cancer patients. However, patients with oestrogen receptor positive (ER+) tumors often display only low lymphocyte infilt...
Schistosoma excretory/secretory products: an untapped library of tolerogenic immunotherapeutics against food allergy [0.03%]
血吸虫分泌／排泄产物：针对食物过敏的耐受性免疫治疗药物的未开发库
Madeleine Rogers,Sandip Kamath,Donald McManus et al.
Madeleine Rogers et al.
Food allergy (FA) is considered the 'second wave' of the allergy epidemic in developed countries after asthma and allergic rhinitis with a steadily growing burden of 40%. The absence of early childhood pathogen stimulation embodied by the h...
Anti-signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury [0.03%]
抗信号识别颗粒抗体通过氧化应激损伤诱导心脏舒张功能障碍
Hao Zhang,Yunjing Shi,Yingze Fan et al.
Hao Zhang et al.
Objectives: Anti-signal recognition particle (SRP) antibodies, markers of immune-mediated necrotising myopathy, are reportedly related to cardiac involvement; however, whether they are pathogenic to the myocardium remains...
Primary SARS-CoV-2 infection in children and adults results in similar Fc-mediated antibody effector function patterns [0.03%]
儿童和成人初次感染SARS-CoV-2后产生的抗体效应功能模式相似
Anne T Gelderloos,Anke J Lakerveld,Rutger M Schepp et al.
Anne T Gelderloos et al.
Objectives: Increasing evidence suggests that Fc-mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS-CoV-2. However, limited data are available on the pote...
Serological responses and clinical outcomes following a three-dose primary COVID-19 vaccine schedule in kidney transplant recipients and people on dialysis [0.03%]
肾移植受者和透析患者的三种新冠疫苗的血清学反应及临床结果
Dhakshayini Tharmaraj,Irene Boo,Jessie O&#x;Hara et al.
Dhakshayini Tharmaraj et al.
Objectives: Despite vaccination strategies, people with chronic kidney disease, particularly kidney transplant recipients (KTRs), remained at high risk of poor COVID-19 outcomes. We assessed serological responses to the t...
Spatial proteomic profiling of tumor and stromal compartments in non-small-cell lung cancer identifies signatures associated with overall survival [0.03%]
非小细胞肺癌肿瘤和间质区室的空间蛋白质组分析鉴定出与总生存率相关的标志物
Vahid Yaghoubi Naei,James Monkman,Habib Sadeghirad et al.
Vahid Yaghoubi Naei et al.
Objectives: Non-small-cell lung carcinoma (NSCLC) is the most prevalent and lethal form of lung cancer. The need for biomarker-informed stratification of targeted therapies has underpinned the need to uncover the underlyi...
Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma [0.03%]
新型FAP特异性CAR-T细胞通过旁观者杀伤机制增强对胶质母细胞瘤的活性
Wenbo Yu,Nga Th Truong,Ruhi Polara et al.
Wenbo Yu et al.
Objectives: CAR-T cells are being investigated as a novel immunotherapy for glioblastoma, but clinical success has been limited. We recently described fibroblast activation protein (FAP) as an ideal target antigen for gli...