A novel case of autosomal recessive CARD11 loss-of-function underlying impaired antiviral immunity and a review of literature [0.03%]
Hamish Anderson,Cecilia Verryt,Paula Keating et al.
Hamish Anderson et al.
Objectives: Germline CARD11 variants lead to a spectrum of disease depending on the effect of signalling augmentation or impairment. Autosomal recessive (AR) CARD11 loss-of-function (LOF) is rare with only 12 cases report...
Enhanced Fc and complement activity of Fc-modified avelumab boosts anti-tumor activity but promotes NK cell fratricide [0.03%]
Lachlan J Dobson,Barry D Hock,Ariana Ht Drabble et al.
Lachlan J Dobson et al.
Objectives: The anti-PD-L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD-1/L1 immune checkpoint, while inducing antibody-dependent cellular cytotoxicity (ADCC) ...
High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third-trimester pregnancy [0.03%]
高维多组学揭示了妊娠晚期CD4+T细胞中IL-6/IL-6R轴和RUNX3的扰动现象
Jennifer R Habel,Thi H O Nguyen,Natasha de Alwis et al.
Jennifer R Habel et al.
Objectives: CD4+ T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4+ T-cell surface proteome and transcriptome during pregnancy. ...
Unveiling the immune landscape and microenvironmental architecture of IgA nephropathy using single-cell imaging mass cytometry [0.03%]
利用单细胞成像质谱流式细胞术解析IgA肾病免疫图谱及微环境架构
Xing Chen,Long Liu,Lijing Yao et al.
Xing Chen et al.
Objective: The heterogeneity in the pathology of IgA nephropathy (IgAN) represents a significant gap in current research, emphasising the need for individualised treatment strategies. The role of the glomerular microenvir...
cGAS inhibitor IMSB301 modifies interferon signalling in peripheral mononuclear cells of SAMHD1 genetic interferonopathy in vitro [0.03%]
cGAS抑制剂IMSB301可改善体外SAMHD1基因干扰素病的外周血单个核细胞的干扰素信号通路异常
Velda X Han,Jessica P Hayes,Lijun Sun et al.
Velda X Han et al.
Objectives: Aicardi-Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism that lacks effective disease modifying therapies. ...
Helminths as architects of trained tolerance: implications for human health [0.03%]
蠕虫与训练耐受性：对人类健康的意义
Quinn Moroz,Jorge Lucas Nascimento Souza,Neima Briggs
Quinn Moroz
Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low-resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable th...
An Ad26-MVA-BN-based therapeutic vaccine targeting HPV16 and HPV18 related disease is immunogenic in preclinical models and in women with persistent HPV infections [0.03%]
一种以Ad26-MVA-BN为基础可针对HPV16和HPV18相关疾病的治疗性疫苗对临床前模型及持续性HPV感染者具有免疫原性
Selina Khan,Satish Boedhoe,Miranda Baert et al.
Selina Khan et al.
Objectives: To develop a therapeutic human papillomavirus (HPV) vaccine capable of intercepting HPV-related cervical disease to reduce the number of new cancer cases and associated deaths. ...
Adaptive immune response to the autoantigen LL-37 differentiates atherosclerotic cardiovascular disease phenotypes [0.03%]
适应性免疫反应与自身抗原LL-37区分动脉粥样硬化心血管疾病表型
Paul C Dimayuga,Kuang-Yuh Chyu,Jianchang Zhou et al.
Paul C Dimayuga et al.
Atherosclerosis is the common underlying pathology in atherosclerotic cardiovascular disease (ASCVD) phenotypes of myocardial infarction (MI), stroke or peripheral artery disease (PAD). Single immune cell profiling of atherosclerotic plaque...
Integration of single-cell and bulk transcriptomics reveals the association of manganese metabolism-related genes with prognosis and immune infiltration in lung adenocarcinoma [0.03%]
单细胞和bulk转录组学的整合分析揭示肺腺癌中锰代谢相关基因与预后及免疫浸润的关系
Hongliang Li,Shuzhen Wei,Wei Li et al.
Hongliang Li et al.
Background: Lung adenocarcinoma (LUAD) is associated with a poor prognosis. Manganese metabolism plays a critical role in antitumor immunity. The prognostic significance of manganese metabolism-related genes (MRGs) in LUA...
Seropositivity against rubella virus envelope protein 1, but not 2, is associated with an increased risk of multiple sclerosis [0.03%]
Rubella病毒包膜蛋白1抗体阳性而非包膜蛋白2抗体阳性与增加的多发性硬化症风险相关
Jens Ingvarsson,Viktor Grut,Martin Biström et al.
Jens Ingvarsson et al.
Objective: Several factors have been associated with altered risk of developing multiple sclerosis (MS). Epstein-Barr virus (EBV) is the critical risk factor for MS, but recent studies indicate that human herpesvirus 6A (...