Humoral and cellular responses to SARS-CoV-2 variants after ancestral COVID-19 vaccines in people with HIV and lung transplant recipients [0.03%]
HIV感染者和肺移植受者接种祖先新冠疫苗后对SARS-CoV-2变异株的体液免疫和细胞免疫反应
David Wj Griffin,Paul A Gill,Irene Boo et al.
David Wj Griffin et al.
Objectives: Immunocompromised hosts have reduced immune responses to COVID-19 vaccination, and more severe disease. Antibody responses correlate with protection but markers of immunity vary across a spectrum of immunocomp...
CD4+ T-cell responses directed towards A/H5N1-derived haemagglutinin peptides increase in patients with seasonal influenza A virus infection [0.03%]
季节性流感病毒感染可增加患者针对A/H5N1衍生血凝素肽的CD4+T细胞反应
Lilith F Allen,Louise C Rowntree,Mitchell Jenzen et al.
Lilith F Allen et al.
Objectives: Recent outbreak of influenza A/H5N1 viral infections in birds and mammals worldwide prompted renewed concerns over an emerging H5N1-related influenza pandemic in the generally immunologically-naive global popu...
High IL-10 levels during CRS are negatively associated with NK-cell recovery after CAR-T cell therapy [0.03%]
CAR-T细胞治疗后，CRS期间高水平的IL-10与NK细胞恢复不良有关
Xindi Wang,Wenjing Luo,Yingying Li et al.
Xindi Wang et al.
Objectives: Immune reconstitution following chimeric antigen receptor (CAR)-T cell therapy remains a critical clinical challenge, and the determinants of natural killer (NK)-cell recovery are not fully understood. ...
Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, Ov MANE1: preclinical evaluation in a mice model [0.03%]
一种针对人类河盲症疫苗候选者Ov MANE1的佐剂型疫苗在小鼠模型中的安全性及免疫原性评价研究
Derrick Neba Nebangwa,Mary Teke Efeti,Sonia M E Momnougui et al.
Derrick Neba Nebangwa et al.
Objectives: Onchocerciasis, caused by the filarial worm Onchocerca volvulus, remains a major public health challenge because of the limitations of ivermectin-based control strategies, thereby highlighting the need for mor...
Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome [0.03%]
早期大脑穿透性免疫疗法逆转ADAR1相关Aicardi-Goutières综合征的I型干扰素特征并改善运动结局
Russell C Dale,Jessica Hayes,Velda X Han et al.
Russell C Dale et al.
Objectives: Aicardi-Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagno...
Clinical, biological and cytometric characteristics of two patients with a homozygous A91V PRF1 mutation [0.03%]
两项研究显示两名患者的临床特征、生物特征及细胞计量学特征均具有PRF1基因纯合子A91V突变的特征
Nicolas Perrard,Claire Poggi,Sébastien Sanges et al.
Nicolas Perrard et al.
Objectives: Inborn errors of immunity are rare genetic disorders that cause dysfunction of the immune system. Among these, familial haemophagocytic lymphohistiocytosis (FHL) involves defects in the perforin/granzyme pathw...
Effect of CXCR5, PD-1 and ICOS on B-cell responses and relevance to myasthenia gravis [0.03%]
CXCR5、PD-1和ICOS对B细胞反应的影响及其与重症肌无力的关系
Merve Çebi,Arman Çakar,Hacer Durmuş et al.
Merve Çebi et al.
Objectives: T follicular helper (Tfh) cells regulate B-cell responses within germinal centres primarily via programmed cell death protein 1 (PD-1) and inducible T-cell costimulator (ICOS), whereas CXC chemokine receptor t...
Development and functional adaptation of intestinal macrophages across the lifespan [0.03%]
生命周期中肠巨噬细胞的发育及其功能适应性变迁
Baha Mustafa,Elisa L Hill-Yardin,Sarah J Spencer
Baha Mustafa
Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional diversification and life stage-specific roles remain incompletely integrated. This review aimed to p...
Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity [0.03%]
饮食诱导的肥胖期间髓系HDAC7驱动肝炎和全身血糖紊乱
Yizhuo Wang,Divya Ramnath,Kaustav Das Gupta et al.
Yizhuo Wang et al.
Objectives: Histone deacetylase 7 (HDAC7), a classical HDAC family member, promotes LPS-inducible glycolysis and inflammatory mediator production in macrophages, innate immune cells that contribute to pathology in metabol...
Single-cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy [0.03%]
单细胞和谱系分析揭示了儿童上呼吸道的免疫重塑：来自腺样增生的启示
Chao Wang,Yufei Pan,Xiao Han et al.
Chao Wang et al.
Objectives: To characterise the immune cellular landscape and paired B-cell and T-cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea. ...