Targeting mitochondrial oxidative stress: A novel therapeutic strategy for degenerative joint diseases (Review) [0.03%]
targeting线粒体氧化应激：退行性关节病的新型治疗策略(综述)
Yang Hou,Xiaolei Yang,Tianyi Zhao et al.
Yang Hou et al.
Degenerative joint diseases, such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA), cause pain and disability worldwide. Globally, OA affects >500 million individuals, IVDD affects 40-60% of adul...
Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome [0.03%]
多氯联苯153可改变肠道上皮细胞转录组
Hanna Ham,Prakrti Senthil,Stephanie C Tan et al.
Hanna Ham et al.
Polychlorinated biphenyl 153 (PCB153) is one of the most persistent environmental pollutants and abundant PCB congeners detected in human tissues, primarily acquired through dietary exposure. The intestinal epithelium therefore represents a...
Clinical application of the HALP score for predicting early neurological deterioration in older patients with acute cerebral infarction [0.03%]
HALP评分在老年急性脑梗死患者早期神经功能恶化的临床预测中的应用
Yong-Juan Lin,Ai-Bin Guo,Ming-Min Huang et al.
Yong-Juan Lin et al.
The present study aimed to examine the relationship between the composite biomarker hemoglobin, albumin, lymphocyte and platelet (HALP) score and early neurological deterioration (END) to identify patients predisposed to poor neurological o...
Cardiorenal safety and efficacy of angiotensin receptor-neprilysin inhibitors in heart failure across the ejection fraction spectrum: A meta-analysis and meta-regression of RCTs with 28,001 patients [0.03%]
射血分数谱系心力衰竭患者中血管紧张素受体-中性肽酶抑制剂的心肾安全性和疗效的meta分析和meta回归：涉及28001名患者的随机临床试验
Derren D C H Rampengan,Stevanus C Surya,Kevin C Tjandra et al.
Derren D C H Rampengan et al.
Angiotensin receptor-neprilysin inhibitors (ARNIs), including sacubitril/valsartan, exert blood pressure-lowering and organ-protective effects in patients with heart failure (HF). However, differences of these effects across HF phenotypes a...
Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation [0.03%]
雷贝拉唑通过调节SMAD3连接区磷酸化抑制纤维化
Linkai Li,Zhen Liang,Long Fan et al.
Linkai Li et al.
Epithelial-to-mesenchymal transition (EMT) and fibrosis are well-established biological outcomes of TGFβ-mediated signaling. Rabeprazole, a proton pump inhibitor (PPI), has been widely used as a first-line therapy for H. pylori infection. ...
Preventive effects of Dendrobium hybrid extract on free radical activity and melanoma cell proliferation by inducing apoptotic gene expression [0.03%]
石斛杂交品种提取物通过诱导凋亡基因表达降低自由基活性和黑色素瘤细胞增殖作用研究
Rungpailin Khonsap,Pilairath Meksangsee,Pichamon Kiatwuthinon et al.
Rungpailin Khonsap et al.
Dendrobium species are used in folk medicines due to their medicinal properties by acting as antioxidants and anticancer agents. Derived from parent plants used in dermatological treatments and cosmetics, Dendrobium Pearl Vera hybrid (DH) w...
ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cells [0.03%]
ERp46通过减轻脂毒性内质网应激来维持β细胞中的GLUT2表达和胰岛素分泌
Danling Chen,Xiaomin Chen,Yuan Tian et al.
Danling Chen et al.
Lipotoxicity-induced β-cell dysfunction is a critical contributor to the pathogenesis of type 2 diabetes mellitus. The aim of the present study was to investigate the role of endoplasmic reticulum-resident protein 46 (ERp46) in regulating ...
Silencing of lncRNA TFAP2A-AS1 attenuates the development of acute coronary syndrome by inhibiting TFAP2A expression [0.03%]
lncRNA TFAP2A-AS1沉默通过抑制TFAP2A表达抑制急性冠脉综合征发展
Shiwei Huang,Fanlu Guan,Fanhao Ye et al.
Shiwei Huang et al.
Acute coronary syndrome (ACS), the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide. The present study aimed to elucidate the preliminarily biological role and underlying mechanism of...
Association of PLA2G2A single nucleotide polymorphism and cardiometabolic diseases in an HIV-infected population [0.03%]
PLA2G2A单核苷酸多态性与HIV感染者的心代谢性疾病的相关性研究
Elvis Ngwa Ndonwi,Unati Nqebelele,Tandi Edith Matsha et al.
Elvis Ngwa Ndonwi et al.
While single nucleotide polymorphisms (SNPs) of the phospholipase A2 (PLA2) gene have been associated with cardiometabolic diseases (CMDs), such associations are yet to be demonstrated in a human immunodeficiency virus (HIV)-infected Africa...
Knockdown of ALOX15 alleviates acute coronary syndrome via the FGFR2/PI3K/AKT signaling pathway [0.03%]
ALOX15敲低通过FGFR2/PI3K/AKT信号通路缓解急性冠脉综合征
Hao Chen,Ning Zhu,Shiwei Huang et al.
Hao Chen et al.
Acute coronary syndrome (ACS) is a serious cardiovascular condition and a leading cause of mortality worldwide. Notably, 12/15-lipoxygenase (ALOX15) can be regulated by the long non-coding RNA ENST00000538705.1, thereby facilitating the pro...