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ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cells

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Lipotoxicity-induced β-cell dysfunction is a critical contributor to the pathogenesis of type 2 diabetes mellitus. The aim of the present study was to investigate the role of endoplasmic reticulum-resident protein 46 (ERp46) in regulating glucose transporter ... ...