Effects of cyclic acute and chronic hypoxia on the expression levels of metabolism related genes in a pancreatic cancer cell line [0.03%]
周期性急性及慢性缺氧对胰腺癌细胞系代谢相关基因表达的影响
Nour M Obeidat,Malek A Zihlif,Dana A Alqudah et al.
Nour M Obeidat et al.
The aim of this study was to characterize cycling hypoxia-induced changes in the expression of metabolism-related genes in the pancreatic cancer cell line PANC1. PANC1 cells were exposed to either 7 h cycles of hypoxia every other day for 2...
Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells [0.03%]
仑伐替尼对肝癌细胞周期及微小核糖核酸谱的影响
Mai Nakahara,Shintaro Fujihara,Hisakazu Iwama et al.
Mai Nakahara et al.
Lenvatinib is a tyrosine kinase receptor inhibitor used to treat unresectable hepatocellular carcinoma (HCC). In this study, we investigated the antitumor effects of Lenvatinib treatment on HCC cell lines. Proliferation was examined in four...
Inhibitory effect of low‑intensity pulsed ultrasound on the fibrosis of the infrapatellar fat pad through the regulation of HIF‑1α in a carrageenan‑induced knee osteoarthritis rat model [0.03%]
低强度脉冲超声通过调节HIF-1α抑制卡瑞喃诱导的膝骨关节炎模型中髌下脂肪垫纤维化的作用
Takashi Kitagawa,Hirohisa Kawahata,Motokuni Aoki et al.
Takashi Kitagawa et al.
Fibrotic changes in the infrapatellar fat pad (IFP) are involved in the pathogenesis of knee osteoarthritis (KOA). HIF-1α is a transcription factor that is activated during hypoxia and is suggested to play a role in fibrosis in various org...
Importance of the neutrophil‑to‑lymphocyte ratio as a prognostic factor in patients with spleen trauma: A single center experience [0.03%]
中性粒细胞与淋巴细胞比率在脾脏损伤患者预后评估中的作用：单中心经验总结报告
Vlad Vunvulea,Bogdan Andrei Suciu,Iuliu Gabriel Cocuz et al.
Vlad Vunvulea et al.
Abdominal trauma is a common diagnosis for patients admitted to the emergency room. Evaluation of the severity of such patients can sometimes be difficult due to rapid hemodynamic changes caused by the activation of inflammatory and anti-in...
Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging [0.03%]
蓝色激光成像量化分析十二指肠乳头胆汁池与腹痛症状的关系
Daiki Abe,Tsutomu Takeda,Daisuke Asaoka et al.
Daiki Abe et al.
Bile acids are strongly associated with the pathogenesis of functional gastrointestinal diseases. In recent years, blue laser imaging (BLI) endoscopy has emerged as a novel image-enhanced endoscopic method, which illustrates bile as a reddi...
Cilostazol regulates the expressions of endothelin-1 and endothelial nitric oxide synthase via activation of the p38 MAPK signaling pathway in HUVECs [0.03%]
西洛他唑通过激活HUVEC中p38MAPK信号途径调节内皮素-1和血管内皮生长硝酸酶的表达
Ying Xue,Xiaoye Li,Zi Wang et al.
Ying Xue et al.
Cilostazol is a selective inhibitor of phosphodiesterase type III that inhibits platelet aggregation. The beneficial effects of cilostazol have been attributed not only to its antiplatelet functions but also to its actions on the endotheliu...
β cell regeneration and novel strategies for treatment of diabetes (Review) [0.03%]
β细胞再生及糖尿病治疗新策略（综述）
Zengyang Ji,Min Lu,Huanhuan Xie et al.
Zengyang Ji et al.
The etiology of diabetes is primarily attributed to the lack of functioning β cells, which in-turn leads to insulin deficiency or insulin resistance, and this ultimately leads to β cell dysfunction. Restoring the number and function of β...
Renin-angiotensin system inhibitors may have an advantage over calcium channel blockers in reducing proteinuria in gastric cancer patients receiving ramucirumab [0.03%]
对于接受雷莫芦单抗治疗的胃癌患者，肾素血管紧张素系统抑制剂可能比钙通道阻滞剂更有利于降低蛋白尿水平
Takeshi Chiba,Haruki Ujiie,Yukiko Yaegashi et al.
Takeshi Chiba et al.
This study aimed to investigate whether renin-angiotensin system inhibitors (RAS-I) have an advantage over calcium channel blockers (CCB) for suppression of proteinuria in hypertensive patients with gastric cancer receiving ramucirumab (RAM...
Possible role of low dose dexamethasone administration in listeria monocytogenes meningoencephalitis: A case series [0.03%]
地塞米松治疗李斯特菌脑膜脑炎的潜在作用：系列病例报告
Vittoria Moscatt,Andrea Marino,Manuela Ceccarelli et al.
Vittoria Moscatt et al.
Listeria (L.) monocytogenes is a gram-positive, non-sporulating, facultatively anaerobic bacillus transmitted to humans through ingestion of contaminated foods. Listeriosis represents the third most common cause of death from foodborne illn...
Factors associated with favorable outcomes in acute severe stroke patients: A real-world, national database study [0.03%]
急性严重卒中患者良好预后的相关因素——一项基于全国真实世界数据库的研究
Narongrit Kasemsap,Nisa Vorasoot,Kannikar Kongbunkiat et al.
Narongrit Kasemsap et al.
Thrombolytic therapy is useful in severe stroke, but it increases the risk of intracerebral hemorrhage. In addition, it may have limited use in resource-limited due to a lack of trained neurologists and equipment to perform CT scans. There ...