High glucose promotes cisplatin chemoresistance in MDA-MB-231 breast cancer derived cells through changes in gene expression and multiple signaling pathways [0.03%]
高血糖通过改变基因表达和多种信号通路促进MDA-MB-231乳腺癌衍生细胞的顺铂耐药性
Araceli Rubí Viedma-Rodríguez,María Guadalupe Martínez-Hernández,Luis Antonio Flores-López et al.
Araceli Rubí Viedma-Rodríguez et al.
Epidemiological and experimental evidence indicate that hyperglycemia, transient hyperinsulinemia and insulin-like growth factor-1 promote an aggressive phenotype of breast tumor cells during diabetes mellitus. The present study evaluated t...
Proteomic analysis identifies novel molecular signatures and immune-metabolic pathways in rheumatoid arthritis-associated interstitial lung disease [0.03%]
蛋白质组分析鉴定出类风湿关节炎相关间质性肺疾病的新型分子特征和免疫代谢通路
Wei Cui,Yan Zhang,Qing Ye et al.
Wei Cui et al.
Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation of RA characterized by complex pathogenesis and limited therapeutic options. The present study aimed to identify circulating s...
Clinical utility of calculated haematological parameters in the diagnosis of iron deficiency anaemia in pregnant women [0.03%]
计算血液学参数在妊娠妇女缺铁性贫血诊断中的临床应用价值
Danijela Županić,Alenka Višnić,Tina Brenčić et al.
Danijela Županić et al.
Iron deficiency anaemia (IDA) is a common condition during pregnancy. The aim of the present study was to determine the diagnostic accuracy measures and define the optimal parameters for diagnosing IDA. Simple parameters, such as erythrocyt...
Inflammation-immune-nutrition biomarkers and PSA variability: A population-based study on the clinical potential of the CALLY index [0.03%]
炎症免疫营养生物标志物和PSA波动：一项关于CALLY指数临床潜力的基于人群的研究
Hesong Jiang,Xiaobing Niu,Fei Mao
Hesong Jiang
Prostate cancer (PCa) is the second leading cause of cancer-associated mortalities worldwide. Prostate-specific antigen (PSA) testing is pivotal for screening for PCa, despite its limited specificity due to confounding factors such as infla...
Potential of doxofylline in the treatment of chronic obstructive airway diseases (Review) [0.03%]
多索利林在慢性阻塞性气道疾病治疗中的潜力（综述）
Serghei Covantsev,Diana Poparcea,Anna Bumbu et al.
Serghei Covantsev et al.
Doxofylline, a xanthine derivative introduced in 1987, was developed as an alternative to theophylline for the treatment of chronic respiratory disease, including chronic obstructive pulmonary disease and bronchial asthma, but also a promis...
Cannabis use and its impact on respiratory physiology and lung cancer risk: Mechanistic and epidemiological insights (Review) [0.03%]
大麻使用及其对呼吸生理和肺癌风险的影响：机制和流行病学见解(综述)
Vasiliki Epameinondas Georgakopoulou,Dimitrios A Andreikos,Wei Zhu et al.
Vasiliki Epameinondas Georgakopoulou et al.
Cannabis use has become increasingly prevalent due to legalization and social acceptance, raising concerns about its potential health impacts, particularly on respiratory and oncological outcomes. Despite sharing toxic constituents with tob...
VDAC1: The mitochondrial gatekeeper in the battle against hearing loss (Review) [0.03%]
VDAC1：对抗听力损失战役中的线粒体守门人（综述）
Zhong-Jia Ding,Yin Wang
Zhong-Jia Ding
The development of hearing loss is strongly associated with mitochondrial damage, particularly downstream of mitochondrial autophagy, which is a process that is coincidentally key for selectively removing damaged mitochondria. Voltage-depen...
Spermidine mitigates lipopolysaccharide-induced acute lung injury by enhancing autophagic flux [0.03%]
spermidine通过增强自噬流来缓解脂多糖诱导的急性肺损伤
Xin Zhang,Haining Lu,Xingsheng Xu
Xin Zhang
The primary pathological characteristics of acute lung injury (ALI), comprise the dysfunction of the endothelial barrier, primarily due to the death of pulmonary microvascular endothelial cells (PMVECs), with pyroptosis identified as the pr...
Short-term cognitive effects of anticholinergics in patients with neurogenic lower urinary tract dysfunction: A systematic review and meta-analysis [0.03%]
抗胆碱药对神经源性下尿路功能障碍患者短期认知影响的系统评价和 meta 分析
Hui Zhang,Yahong Wang
Hui Zhang
Neurogenic lower urinary tract dysfunction (NLUTD) is common in individuals with neurological disorders, leading to bladder overactivity and incontinence. Anticholinergic medications are frequently prescribed for symptom control, but concer...
Hsa_circ_0122913 suppresses the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells and is involved in the effects of icariin treatment via sponging miR-501-5p [0.03%]
CircRNA Hsa_circ_0122913通过海绵吸附miR-501-5p抑制骨髓间充质干细胞的增殖和成骨分化并参与淫羊藿素作用效应
Yeqing Wang,Minbo Liu,Changhua Liu et al.
Yeqing Wang et al.
Circular RNAs (circRNAs) play significant roles in several biological events. It has been revealed that hsa_circ_0122913 was upregulated in peripheral blood samples from patients with senile osteoporotic vertebral compression fracture. Ther...