Targeting ULK1 and USP20 to modulate autophagy and chemosensitivity in cancer cell lines [0.03%]
靶向ULK1和USP20以调节癌细胞系中的自噬和化学敏感性
Tuqa Abu Thiab,Malek Zihlif,Dana Alqudah et al.
Tuqa Abu Thiab et al.
Autophagy is a conserved catabolic process essential for maintaining cellular homeostasis by degrading and recycling damaged organelles and misfolded proteins. In cancer, autophagy plays a dual role, acting as both a tumor suppressor and pr...
Chalinasterol attenuates ethanol-induced hepatic lipid accumulation by activating β-oxidation [0.03%]
胆烷醇通过激活β氧化缓解酒精性肝内脂质蓄积效应
Ji Hye Kim,Min Young Kim,Sejong Oh et al.
Ji Hye Kim et al.
Alcoholic liver disease is a global health burden and, during its earliest stage, alcoholic steatosis, it is still reversible. Ethanol promotes hepatic lipid accumulation by enhancing lipogenesis and suppressing fatty acid oxidation. The pr...
Integrated transcriptomic and molecular docking analysis identifies Rhotekin 2 as a promising therapeutic target for overcoming gemcitabine resistance in cholangiocarcinoma [0.03%]
整合转录组和分子对接分析识别Rho衔接蛋白2作为克服肝内胆管癌吉西他滨耐药性的治疗靶点
Sonexai Kidoikhammouan,Panupong Mahalapbutr,Prasertsri Ma-In et al.
Sonexai Kidoikhammouan et al.
Gemcitabine resistance remains a significant problem in cholangiocarcinoma (CCA) treatment. The present study aimed to identify novel molecular targets associated with gemcitabine resistance in CCA using integrated bioinformatics, molecular...
Advances in the management of neuroendocrine tumours: Evidence from a systematic review [0.03%]
神经内分泌肿瘤治疗进展的系统评价证据
Andreea-Daniela Caloian,Sorin Deacu,Miruna Cristian et al.
Andreea-Daniela Caloian et al.
Neuroendocrine tumours (NETs) are rare, biologically diverse neoplasms with a rising incidence due to improved diagnostics. Their management remains challenging, with multiple therapeutic strategies under evaluation. The present systematic ...
Preliminary exploration of the role of CD8+ T cells in anti-PD-1 antibody-induced myocarditis in C57BL/6 mice with Lewis lung carcinoma [0.03%]
C57BL/6小鼠Lewis肺癌模型中抗PD-1抗体诱导的心肌炎的CD8+T细胞作用的初步研究
Huachun Chen,Fakai Li,Jun Song et al.
Huachun Chen et al.
Globally, ~33% of patients with non-small cell lung cancer receiving anti-PD-1 antibody therapy may experience significant immune-related adverse events (irAEs). Among these, myocarditis is a rare but lethal irAE. The aim of the present stu...
Clinically aggressive early-onset pancreatic ductal adenocarcinoma with KRAS wild-type status: A case report [0.03%]
具有野生型KRAS状态的临床侵略性早期胰腺导管腺癌的一例报告
Maria E Avendaño,Cristopher San Martin Abello,Fernán Gómez-Valenzuela et al.
Maria E Avendaño et al.
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal and challenging gastrointestinal (GI) malignancies. Predominant driver mutations for this cancer include KRAS, which is present in >90% of cases, alongside inactivati...
Case Reports
Biomedical reports. 2026 Mar 6;24(5):55. DOI:10.3892/br.2026.2128 2026
Soran H Tahir,Razhan Sabah,Yusif Firas et al.
Soran H Tahir et al.
Anatomical variations of the maxillary sinus have important clinical implications, yet factors influencing maxillary sinus volume (MSV) remain debated. The present study evaluated MSV and related anatomical variations in an Iraqi population...
Description of the novel variant c.784delG;p. (Ala262Profs*68) at BSND gene and its association with Bartter Syndrome Type Iva [0.03%]
BSND基因新型变异c.784delG；p.(Ala262Profs*68)及其与巴特综合征IV型关联的描述
Jéssica Hilário Bonomo,Lívia Cláudio De Oliveira,Maria Do Carmo Sorci Dias Scher et al.
Jéssica Hilário Bonomo et al.
Bartter syndrome (BS) is a group of diseases caused by variants in genes related to salt reabsorption in the thick ascending limb of the loop of Henle. It causes dysregulation in salt homeostasis and is characterized by hyperplasia and hype...
Investigation of genetic and lifestyle risk factors associated with Epstein-Barr virus reactivation in the Thai population [0.03%]
泰国人群EB病毒感染再活化的遗传和生活方式危险因素调查研究
Janpen Bamrungthai,Tipaya Ekalaksananan,Sutida Pongpakdeesakul et al.
Janpen Bamrungthai et al.
Current data on the genetic and lifestyle factors associated with Epstein-Barr virus (EBV) reactivation in the oral cavity are limited for the Thai population. Furthermore, comprehensive data linking EBV reactivation to head and neck cancer...
Comparison of point-of-care HbA1c devices with laboratory HPLC methods: A systematic review and meta-analysis [0.03%]
POCT与实验室HPLC测定糖化血红蛋白方法一致性系统的评价和Meta分析
Yongzhong Wei,Mingze Gu,Yuqing Ren et al.
Yongzhong Wei et al.
Hemoglobin A1c (HbA1c), also known as glycated hemoglobin, is a cornerstone biomarker for diagnosing and monitoring diabetes. While high-performance liquid chromatography (HPLC) is the reference standard, point-of-care (POC) devices are inc...