Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress [0.03%]
NOX1介导的氧化应激促进hesperadin增敏胃癌细胞摄取顺铂
Wanjing Zhu,Qiyin Li,Zhenglei Ji et al.
Wanjing Zhu et al.
The therapeutic efficacy of cisplatin in gastric cancer (GC) is frequently constrained by chemoresistance and systemic toxicity. Targeted small molecules hold promise for providing synergistic effects that enhance treatment outcomes. GC cel...
Association of Waardenburg syndrome with a new mutation in the PAX3 gene: A case report and literature review [0.03%]
Waardenburg综合征新的PAX3基因突变病例报告及文献复习
Juliana Zafiri,Elena Papageorgiou,Andreas Pampanos et al.
Juliana Zafiri et al.
The present case report focuses on Waardenburg syndrome (WS), which occurs with a frequency of 1/40,000 and is manifested by neurosensory deafness, pigmentation deficiencies of the skin, hair and iris of the eye, and various tissue defects ...
Case Reports
Biomedical reports. 2025 Oct 7;23(6):189. DOI:10.3892/br.2025.2067 2025
Expression of ACE2 and TMPRSS2 and the severity of COVID-19 [0.03%]
ACE2和TMPRSS2的表达与COVID-19严重性关系的研究
Samantha Sanches De Carvalho,Anna Carolina Blanco Capassi Santos,Marcos Yuji Shiroma Graziano et al.
Samantha Sanches De Carvalho et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), uses the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane serine protease 2 (TMPRSS2) to enter hos...
Low molecular weight sulfated galactan attenuates imiquimod-induced psoriasis via suppression of proinflammatory cytokines and keratinocyte hyperproliferation [0.03%]
低分子量硫酸盐半乳糖甘露聚糖通过抑制促炎细胞因子和角质形成细胞过度增殖来缓解咪喹莫特诱导的银屑病
Kamonwan Jongsomchai,Arnon Pudgerd,Laorrat Phuapittayalert et al.
Kamonwan Jongsomchai et al.
Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation and immune cell infiltration. Low molecular weight sulfated galactan (LSG), derived from the red seaweed Gracilaria fisheri, ...
High glucose promotes cisplatin chemoresistance in MDA-MB-231 breast cancer derived cells through changes in gene expression and multiple signaling pathways [0.03%]
高血糖通过改变基因表达和多种信号通路促进MDA-MB-231乳腺癌衍生细胞的顺铂耐药性
Araceli Rubí Viedma-Rodríguez,María Guadalupe Martínez-Hernández,Luis Antonio Flores-López et al.
Araceli Rubí Viedma-Rodríguez et al.
Epidemiological and experimental evidence indicate that hyperglycemia, transient hyperinsulinemia and insulin-like growth factor-1 promote an aggressive phenotype of breast tumor cells during diabetes mellitus. The present study evaluated t...
Proteomic analysis identifies novel molecular signatures and immune-metabolic pathways in rheumatoid arthritis-associated interstitial lung disease [0.03%]
蛋白质组分析鉴定出类风湿关节炎相关间质性肺疾病的新型分子特征和免疫代谢通路
Wei Cui,Yan Zhang,Qing Ye et al.
Wei Cui et al.
Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation of RA characterized by complex pathogenesis and limited therapeutic options. The present study aimed to identify circulating s...
Clinical utility of calculated haematological parameters in the diagnosis of iron deficiency anaemia in pregnant women [0.03%]
计算血液学参数在妊娠妇女缺铁性贫血诊断中的临床应用价值
Danijela Županić,Alenka Višnić,Tina Brenčić et al.
Danijela Županić et al.
Iron deficiency anaemia (IDA) is a common condition during pregnancy. The aim of the present study was to determine the diagnostic accuracy measures and define the optimal parameters for diagnosing IDA. Simple parameters, such as erythrocyt...
Inflammation-immune-nutrition biomarkers and PSA variability: A population-based study on the clinical potential of the CALLY index [0.03%]
炎症免疫营养生物标志物和PSA波动：一项关于CALLY指数临床潜力的基于人群的研究
Hesong Jiang,Xiaobing Niu,Fei Mao
Hesong Jiang
Prostate cancer (PCa) is the second leading cause of cancer-associated mortalities worldwide. Prostate-specific antigen (PSA) testing is pivotal for screening for PCa, despite its limited specificity due to confounding factors such as infla...
Potential of doxofylline in the treatment of chronic obstructive airway diseases (Review) [0.03%]
多索利林在慢性阻塞性气道疾病治疗中的潜力（综述）
Serghei Covantsev,Diana Poparcea,Anna Bumbu et al.
Serghei Covantsev et al.
Doxofylline, a xanthine derivative introduced in 1987, was developed as an alternative to theophylline for the treatment of chronic respiratory disease, including chronic obstructive pulmonary disease and bronchial asthma, but also a promis...
Cannabis use and its impact on respiratory physiology and lung cancer risk: Mechanistic and epidemiological insights (Review) [0.03%]
大麻使用及其对呼吸生理和肺癌风险的影响：机制和流行病学见解(综述)
Vasiliki Epameinondas Georgakopoulou,Dimitrios A Andreikos,Wei Zhu et al.
Vasiliki Epameinondas Georgakopoulou et al.
Cannabis use has become increasingly prevalent due to legalization and social acceptance, raising concerns about its potential health impacts, particularly on respiratory and oncological outcomes. Despite sharing toxic constituents with tob...