Apostolos I Gogakos,Stergios A Polyzos,Dimitrios A Anastasilakis et al.
Apostolos I Gogakos et al.
The ubiquity of microplastics and nanoplastics (or microplastic and nanoplastic particles, collectively MNPs) in the modern environment has led to detection of polymer particles and polymer-associated chemicals repeatedly within human tissu...
The IGF Signaling Axis in Thyroid Cancer: Biological Complexity and Therapeutic Challenges [0.03%]
甲状腺癌中的IGF信号轴：生物学复杂性和治疗挑战
Youyun Peng,Shaojie Xu,Hanning Li et al.
Youyun Peng et al.
Dysregulation of the insulin-like growth factor (IGF) axis plays an important role in thyroid cancer progression, dedifferentiation, and therapeutic resistance. While most differentiated thyroid cancers have favorable outcomes, a clinically...
Factors affecting the quality of life of adults living with Congenital Adrenal Hyperplasia: A qualitative study of lived experience [0.03%]
先天性肾上腺增生患者生活质量的影响因素：生活体验的定性研究
K Lynette James,Nicola Parkin,Sue Elford et al.
K Lynette James et al.
Objective: Congenital adrenal hyperplasia (CAH) is a genetic condition caused by enzymatic defects of adrenal steroidogenesis. The physical manifestations of CAH are well recognised but the effects on health-related quali...
Development and External Validation of a Parsimonious Endocrine-Metabolic Model for 12-Month Pregnancy Prediction in Women With PCOS [0.03%]
多囊卵巢综合征女性12个月妊娠预测的内分泌代谢模型的开发和外部验证
Sifu Ha,Lina Liu,Jian Li et al.
Sifu Ha et al.
Background: Women with polycystic ovary syndrome (PCOS) exhibit diverse reproductive and metabolic phenotypes, complicating short-term pregnancy counseling. We developed and externally validated a pragmatic model to predi...
Metformin improves endotoxemia and alters folliculogenesis in women with polycystic ovary syndrome [0.03%]
二甲双胍改善多囊卵巢综合征妇女内毒素血症和卵泡发育不良
Mateusz Trzcinski,Izabela Chudzicka-Strugala,Katherine Kim et al.
Mateusz Trzcinski et al.
Polycystic ovary syndrome (PCOS) is associated with excessive ovarian androgen production, increased number of ovarian follicles and a wide range of other endocrine and metabolic derangements including endotoxemia. Metformin is often used i...
Association of basal thyroid function with clinical outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma treated with PD-L1 inhibitor KL-A167: a multicenter post hoc analysis [0.03%]
基线甲状腺功能与接受PD-L1抑制剂KL-A167治疗的复发或转移性鼻咽癌患者临床结局相关性的多中心事后分析
Keliang Chen,Haohan Fan,Shihong Xu et al.
Keliang Chen et al.
Objective: While thyroid dysfunction during PD-L1 inhibitor therapy correlates with efficacy in recurrent/metastatic nasopharyngeal carcinoma, the prognostic value of basal thyroid function remains unclear. This study inv...
Spectrum and Genotype-phenotype Correlation of NR5A1 Variants in 46, XY DSD: A Systematic Review and Meta-analysis [0.03%]
NR5A1变异在46,XY差异性发育症中的谱系及基因型表型相关性：系统评价和meta分析
Dallago Renata T,Batista Rafael Loch,Domenice Sorahia et al.
Dallago Renata T et al.
Context: NR5A1 encodes steroidogenic factor 1, a master regulator of adrenal and gonadal development. Pathogenic NR5A1 variants are among the most common genetic findings in 46,XY differences of sex development (DSD), yet...
Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice [0.03%]
脂联素通过调节雄性小鼠的昼夜肝脏转录组来影响能量代谢
Misa Hirose,Enrique Calvo,Violetta Pilorz et al.
Misa Hirose et al.
Adiponectin is an adipocyte-derived hormone with insulin-sensitizing and lipid-lowering effects. Its expression and circulating levels show pronounced variation across the day, which opens the possibility that adiponectin influences metabol...
Clinical Characteristics and Management of PD-1/PD-L1 Inhibitor-Induced secondary Adrenal Insufficiency [0.03%]
PD-1/PD-L1抑制剂所致继发性肾上腺功能不全的临床特征及处理措施
Na Li,Tianfu Liang,Hanbing Xie et al.
Na Li et al.
Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors significantly improve outcomes in multiple malignancies; however, they can induce immune-related endocrine adverse events, such as secondary adrenal insufficiency (...
Phosphate handling as a determinant of osteoporosis in primary hyperparathyroidism [0.03%]
原发性甲状旁腺功能亢进症患者骨质疏松的发病机制与磷代谢的关系
Sebastian Szewczyk,Michał Popow,Urszula Ambroziak
Sebastian Szewczyk
Introduction: Primary hyperparathyroidism is characterized by chronic parathyroid hormone excess, leading to hypercalcemia, increased bone turnover, and skeletal complications. Although osteoporosis is a common manifestat...