Clinical and genetic spectrum of cytochrome P450 oxidoreductase deficiency in Chinese patients [0.03%]
中国患者细胞色素P450还原酶缺乏症的临床及基因型研究
TingTing Wang,Chong Li,Chao Han et al.
TingTing Wang et al.
Background: Cytochrome P450 oxidoreductase deficiency (PORD) is a rare autosomal recessive disorder with heterogeneous endocrine, reproductive, DSD-related, and skeletal manifestations. Population-specific data in Chinese...
Impact of GAD-65 antibody detection on antihyperglycemic therapy in T2D [0.03%]
GAD-65抗体检测对2型糖尿病降糖治疗的影响
Sharon Halliburton,Eric Herber,Kevin M Pantalone et al.
Sharon Halliburton et al.
Guidelines recommend that latent autoimmune diabetes in adults be managed similarly to type 1 diabetes, emphasizing early insulin initiation, while other guidance suggests incorporating non-insulin antihyperglycemic therapies based on comor...
Impact of GAD-65 Antibody Detection on Antihyperglycemic Therapy in T2D [0.03%]
GAD-65抗体检测对2型糖尿病降糖治疗的影响
Sharon Halliburton,Eric Herber,Kevin M Pantalone et al.
Sharon Halliburton et al.
Guidelines recommend Latent Autoimmune Diabetes in Adults be managed similar to type 1 diabetes, emphasizing early insulin initiation, while other guidances suggest incorporating non-insulin antihyperglycemic therapies based on comorbiditie...
CYP19A1 Variation in Healthy Children: Associations with Breast Development and Pubertal Gynecomastia [0.03%]
CYP19A1在健康儿童中的变异与乳腺发育和青春期男性乳房发育症的关系
Veronica L R Groendahl,Stine A Holmboe,Alexander S Busch et al.
Veronica L R Groendahl et al.
Background: CYP19A1 encodes aromatase, the enzyme converting androgens to estrogens, thereby influencing breast tissue development in healthy children. Ob...
Artificial intelligence in thyroid nodules and cancer: clinical validation and real-world performance [0.03%]
人工智能在甲状腺结节和癌症中的应用：临床验证及实际性能评估
Mustafa Sahin,Nikolaos George Angelopoulos,Rodis D Paparodis
Mustafa Sahin
Thyroid nodules are detected in a large proportion of adults undergoing high-resolution ultrasonography, yet only a minority harbor clinically significant cancer. The clinical problem is therefore not only cancer detection but calibrated ri...
Artificial intelligence in thyroid nodules and cancer: clinical validation and real-world performance [0.03%]
人工智能在甲状腺结节和癌症中的应用：临床验证与实际性能评估
Mustafa Sahin,Nikolaos George Angelopoulos,Rodis D Paparodis
Mustafa Sahin
Thyroid nodules are detected in a large proportion of adults undergoing high-resolution ultrasonography, yet only a minority harbor clinically significant cancer. The clinical problem is therefore not only cancer detection but calibrated ri...
Fibroblast growth factor 21 and its relationship with central precocious puberty in girls [0.03%]
成纤维细胞生长因子21与中枢性早熟的关系研究
Xiaojing Hao,Jiangya Wang,Ran Zhou et al.
Xiaojing Hao et al.
Background: Studies have shown that obesity and insulin resistance are associated with central precocious puberty (CPP) in girls. Serum fibroblast growth factor 21 (FGF21) levels are associated with obesity and insulin re...
Learning curve of blood pressure management during pheochromocytoma surgery without preoperative alpha-blockade dose-escalation [0.03%]
术前不用α阻断剂滴定的嗜铬细胞瘤手术中的学习曲线及血压管理体验逐渐增加的影响
Isabelle Holscher,Mahsoem Ali,Koen M A Dreijerink et al.
Isabelle Holscher et al.
Background: Adrenalectomy without preoperative dose-escalation of α-blockade is gaining popularity for managing pheochromocytoma, showing comparable outcomes but shorter hospital stays and less postoperative hypotension....
Effects of burosumab on macrophage polarization and TRPV1 expression in children with XLH [0.03%]
布罗舒马斯特对低血磷性维生素D抵抗型佝偻病患儿巨噬细胞极化及TRPV1表达的影响
Alessandra Di Paola,Stefania Palumbo,Lucia Argenziano et al.
Alessandra Di Paola et al.
Purpose: X-linked hypophosphatemia (XLH) is a rare genetic disorder caused by PHEX mutations, leading to hypophosphatemia and impaired bone mineralization. Burosumab, a monoclonal antibody targeting FGF23, improves phosph...
PCOS-like phenotype in rats after intrauterine EV exposure: puberty and adulthood [0.03%]
宫内暴露外泌体对大鼠多囊卵巢综合征样表型的影响：青春期与成年期
Gabriela Rosas,Evelin M Hernández-García,Leonardo Gómez-Emeterio et al.
Gabriela Rosas et al.
Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy affecting female fertility. It has been hypothesized that PCOS has its origins during intrauterine life, where prenatal exposure to endocrine-disrupting environments during ...