Baxdrostat versus Osilodrostat: Steroid Biosynthesis in Human Adrenocortical Cells [0.03%]
巴塞德罗stat与奥斯洛德罗 stat：人肾上腺皮质细胞中类固醇生物合成中的作用
Yuki Taki,Takashi Kono,Ikki Sakuma et al.
Yuki Taki et al.
To compare the functional selectivity of baxdrostat versus osilodrostat in primary human adrenocortical cells, focusing on aldosterone suppression while preserving cortisol biosynthesis, we conducted an experimental ex vivo study using prim...
EXPRESSION OF CONCERN: Intracellular FGF1 promotes invasion and migration in thyroid carcinoma via HMGA1 independent of FGF receptors [0.03%]
表达关注：细胞内FGF1通过HMGA1促进甲状腺癌的侵袭和迁移，独立于FGF受体
Zuyao Chen,Xiaolin Zhong,Weiqiang Tang et al.
Zuyao Chen et al.
Thyroid function tests and resting heart rate in Graves` disease: a prospective longitudinal study [0.03%]
Graves病患者的甲状腺功能和静息心率：一项前瞻性队列研究
Beatrice Egger,Uwe Riedmann,Lisa Schmitt et al.
Beatrice Egger et al.
Objective: Increased resting heart rate (RHR) is a typical sign of thyrotoxicosis. RHR may therefore serve as a monitoring tool, but longitudinal data on continuous measures of RHR and thyroid hormones are sparse. We eval...
Perioperative management of patients with primary aldosteronism: a practical approach for the Endocrinologist [0.03%]
原发性醛固酮增多症患者的围手术期管理：内分泌科医生的实用方法
Patrícia da Cunha Brito,Adriana de Sousa Lages,Catarina Machado et al.
Patrícia da Cunha Brito et al.
Primary aldosteronism (PA) is the most common endocrine cause of secondary hypertension yet remains significantly underdiagnosed. Early recognition is essential, as excess aldosterone leads to substantial cardiovascular and renal morbidity....
LAT1-mediated amino acid metabolism reprogramming: a novel metabolic vulnerability in recurrent pituitary neuroendocrine tumors [0.03%]
LAT1介导的氨基酸代谢重构：促肾上腺皮质激素型垂体神经内分泌肿瘤复发的新代谢弱点
Zhi-Jie Pei,Gao-Wei Li,Jiang-Hao Yu et al.
Zhi-Jie Pei et al.
Objective: Tumor recurrence remains a major challenge in the management of pituitary neuroendocrine tumors (PitNETs). This study aimed to investigate recurrence-associated metabolic alterations in PitNETs using an integra...
Maternal methyl-donor supplementation and hypothalamic methylation stability [0.03%]
母体甲基供体补充与下丘脑甲基化稳定性关系研究
Thomas Gerhard Brune,Bettina Schloesser,Marianne Volleth et al.
Thomas Gerhard Brune et al.
Background: Maternal nutrition can shape fetal epigenetic programming with long-term health effects. This study tested whether central and peripheral tissues differ in responsiveness to maternal methyl-donor supplementati...
German Law on Protection of Children with DSD: First data on care after enactment [0.03%]
德国DSD儿童保护法：实施后的第一次数据考察
Uta Neumann,Gerhard Binder,Felicitas Eckoldt et al.
Uta Neumann et al.
Introduction: In May 2021, a German law was implemented to protect children with differences of sex development (DSD) from non-consensual genital surgery. In children and persons incapable of giving consent, exceptions ca...
Fertility preservation in prepubertal boys: management and follow-up challenges [0.03%]
青春期前男孩的生育力保存：管理和随访挑战
Vittorio Ferrari,Federico Baronio,Marcello Lanari et al.
Vittorio Ferrari et al.
Survival after childhood cancer and severe haematological disorders has improved substantially, shifting clinical attention toward long-term quality-of-life outcomes. Preservation of male reproductive potential represents a major challenge,...
Shared diagnostic biomarkers in metabolic syndrome and coronary artery disease identified by integrated bioinformatics and machine learning [0.03%]
基于集成生物信息学和机器学习的代谢综合征与冠状动脉疾病的共有诊断生物标志物识别研究
Nuojin Wang,Keyan Hu,Shuting Zhang et al.
Nuojin Wang et al.
Background: Metabolic syndrome (MetS) comprises various complicated metabolic disorders. Coronary artery disease (CAD) is a major cardiovascular disease worldwide. These two diseases are principal causes of morbidity and ...
Recognition and accreditation of postgraduate training centers in Endocrinology in Europe [0.03%]
欧洲内分泌学住院医师培训中心的认定与认证
Hans Perrild,Anton Luger,Mirjam Christ-Crain et al.
Hans Perrild et al.
Background: The quality of care of patients with endocrine diseases depends on the training of trainees. To ensure this the European Society of Endocrinology (ESE) and the UEMS (European Union of Medical Specialists) Sect...