Gene expression profiles associated with stimulus-responsive insulin secretion in insulinoma [0.03%]
与刺激诱导的胰岛素分泌相关的基因表达谱系在胰岛细胞瘤中的作用
Kenji Sugawara,Yuko Okada,Tomokazu Matsuda et al.
Kenji Sugawara et al.
Insulinoma is a functional pancreatic neuroendocrine tumor that usually causes fasting hypoglycemia through inappropriate autonomous insulin secretion. However, some insulinomas show postprandial or stimulus-induced hypoglycemia, suggesting...
Post-bariatric hypoglycaemia: from altered gut physiology to targeted therapies [0.03%]
代谢手术后低血糖：从肠道生理变化到靶向治疗
Wei Yang,Tricia M-M Tan
Wei Yang
Post-bariatric hypoglycaemia (PBH) is an increasingly recognised complication of bariatric and metabolic surgery, that can markedly impair quality of life and jeopardise the long-term benefits of surgery. This review summarises the current ...
Group education improves self-management of adrenal insufficiency in patients and their relative [0.03%]
群体教育改善了肾上腺功能不全患者及其家属的自我管理能力
Anna-Karin Åkerman,Charlotte Höybye,Katarina Berinder et al.
Anna-Karin Åkerman et al.
Objective: Self-management and patient education are cornerstones in managing adrenal insufficiency (AI), to prevent adrenal crisis (AC). Glucocorticoid (GC) education group meetings are increasingly being incorporated in...
Dampened HPG axis activity and altered ovarian gene transcription in Dummerstorf high-fertility mouse line FL2 [0.03%]
抑制下丘脑-垂体-性腺轴活性和Dummerstorf高生育力小鼠品系FL2卵巢基因转录的改变
Carolin L M Ludwig,Simon Bohleber,Anja Baufeld et al.
Carolin L M Ludwig et al.
Animal models of enhanced fertility are rare, as most genetically modified mouse models with reproductive phenotype display subfertility or infertility. Here we describe the ovarian phenotype of the Dummerstorf line 2 (FL2) mouse strain, wh...
Omer Denizhan Tatar
Omer Denizhan Tatar
This Perspective comments on a recent national cohort study of ectopic ACTH syndrome that identified late-night salivary cortisol (LNSC) ≥130 nmol/L as an independent predictor of mortality. The finding is clinically important because it s...
Bone turnover marker rhythmicity: implications for osteoporosis treatment and fracture healing [0.03%]
骨转换标记的节律性：对骨质疏松症治疗和骨折愈合的意义
Megan M Tidd,Christine M Swanson
Megan M Tidd
Abstract: Bone turnover is a dynamic process with markers of bone turnover displaying varying degrees of rhythmicity. The objective of this narrative review was to synthesize current evidence on the regulation of bone tur...
Beyond the GH-IGF-1 Axis: A Network Perspective Integrating Clinical Observations and Mechanistic Insights [0.03%]
超越GH-IGF-1轴：整合临床观察和机制见解的网络视角
Go Yoshimichi
Go Yoshimichi
Background: Obesity encompasses a heterogeneous group of conditions that include not only simple obesity, but also genetic and endocrine disorders. The growth hormone (GH)-insulin-like growth factor 1(IGF-1) axis plays a ...
Thyroid function, nutritional status, inflammation, and sarcopenia in haemodialysis patients: an integrated cross-sectional analysis [0.03%]
血液透析患者的甲状腺功能、营养状况、炎症和肌少症的综合横断面分析
Karina Schiavoni Scandelai,Hércules Rezende Freitas,Maria das Graças Coelho de Souza et al.
Karina Schiavoni Scandelai et al.
Objective: To investigate the interrelationships among thyroid function, nutritional status, inflammation, and sarcopenia in patients undergoing haemodialysis (HD), and to identify variables associated with sarcopenia usi...
Pharmacovigilance Evaluation of Somatrogon-Associated Adverse Events in Real-World Databases [0.03%]
基于真实世界数据库的Somatrogon相关不良事件的药理学评价
Mengyuan Cai,Qian Guo,Huqiang Dong et al.
Mengyuan Cai et al.
Background: Somatrogon, a long-acting recombinant human growth hormone, is used in children with growth hormone deficiency. While clinical trials have shown its safety, real-world post-marketing data are limited, and unco...
Increased Mortality in Chronic Hypoparathyroidism: A Nationwide Cohort Study in Sweden [0.03%]
瑞典慢性低甲状旁腺素血症患者死亡率增高的全国队列研究
Wafa Kamal,Ylva Trolle Lagerros,Michael Mannstadt et al.
Wafa Kamal et al.
Context: Previous studies on mortality outcomes in patients with chronic hypoparathyroidism have reported inconsistent results. Objective: ...