Cardiometabolic Insights in Cystic Fibrosis and Highly Effective Modulator Therapies: a Narrative Review [0.03%]
囊性纤维化和高效调节治疗的心血管代谢新见解：综述
Fabian O Lurquin,Michel P Hermans,Sophie Gohy et al.
Fabian O Lurquin et al.
Alongside pulmonary and nutritional benefits, highly effective modulator therapies (HEMT) can promote an increase in body fat and raise the prevalence of overweight/obesity, dyslipidemia, and hypertension in patients with cystic fibrosis. T...
Continuity of care in Klinefelter syndrome: age-adapted modules for standardized clinical data collection (I-KS) [0.03%]
克兰费尔特综合征的连续护理：适应年龄的模块化标准化临床数据采集(I-KS)
Corinna Grasemann,Claus H Gravholt,Lexi Breen et al.
Corinna Grasemann et al.
Abstract: Klinefelter syndrome (KS) is an underdiagnosed condition, affecting approximately 1 in 600 male births. Despite its relatively high prevalence, more than two-thirds of affected individuals remain undiagnosed, an...
Gwen Lomberk,Rosalia C M Simmen
Gwen Lomberk
A Predictive Nomogram for Treatment Response in Osteonecrosis Patients Receiving Denosumab with UKA: Integrating Bone Turnover Markers and Functional Parameters [0.03%]
结合骨转换标志物和功能参数的骨坏死患者接受地诺单抗联合UKA治疗反应预测 nomogram集成
Guoping Zou,Keke Pu,Yuanyuan Zeng et al.
Guoping Zou et al.
Background: s: Primary spontaneous osteonecrosis of the knee (SONK) is a debilitating condition that primarily affects elderly patients with an unknown etiology. Denosumab has emerged as a novel therapeutic agent for oste...
Long-term intranasal oxytocin therapy in patients with hypothalamic syndrome: case series and literature review [0.03%]
下丘脑综合征患者长期鼻内给药催产素治疗：病例系列和文献综述
Yusi Wang,Yi Wang,Bingyan Cao et al.
Yusi Wang et al.
Context: Hypothalamic syndrome (HS) is a rare endocrine disorder, resulting from Prader-Willi syndrome (PWS), craniopharyngiomas, ROHHAD syndrome and unknown etiologies. Oxytocin has been shown to facilitate weight loss i...
Performance of diabetes risk prediction models: A systematic review and meta-analysis [0.03%]
糖尿病风险预测模型性能的系统综述和 Meta 分析
Meichen Li,Aowei Tan,Linjie Song et al.
Meichen Li et al.
Background: Type 2 diabetes mellitus (T2DM) poses a significant global public health burden, where early detection of at-risk populations is imperative for implementing targeted preventive strategies. This systematic revi...
Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density [0.03%]
月经周期性状与骨矿物质密度共享遗传结构的全基因组新见解
Bowen Lei,Lin He,Yang Qu et al.
Bowen Lei et al.
Objective: While the phenotypic associations of menstrual traits, such as age at menarche (AAM) and age at natural menopause (ANM), with bone mineral density (BMD) have been well-observed, the understanding of their share...
Highlights on protein phosphatase 2A (PP2A) functions in male germ cells and its importance for male fertility [0.03%]
蛋白质磷酸酶2A(PP2A)在生精细胞中的功能及其对雄性生育力的影响的研究进展
Violaine Simon
Violaine Simon
Infertility is a common issue that affects approximately 30 million men worldwide, most often resulting from defects during spermatogenesis, a complex cellular differentiation process allowing the formation of spermatozoa. During spermatoge...
Mechanism of KLF7 in regulating the proliferation and apoptosis of granulosa cells in polycystic ovarian syndrome [0.03%]
KLF7在多囊卵巢综合征颗粒细胞增殖及凋亡中的作用机制研究
Honghong Wang,Yanhua Chen,Qiumei Wang et al.
Honghong Wang et al.
Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with the function of granulosa cells. This study was conducted to explore the regulatory mechanism of Kruppel-like factor 7 (KLF7) in t...
Diagnostic Implications of Renin Reactivity in Confirmatory Tests: A Comparative Study of Direct Renin Concentration and Plasma Renin Activity in Primary Aldosteronism [0.03%]
肾素反应性确诊试验的诊断意义：原发性醛固酮增多症患者中直接肾素浓度与血浆肾素活性比较研究
Tomoyuki Nagasaka,Yoshiaki Hishida,Hiroki Yasuda et al.
Tomoyuki Nagasaka et al.
Objective: Renin measurement is a key to diagnosing primary aldosteronism (PA). However, it remains unclear whether plasma renin activity (PRA) or direct renin concentration (DRC), which are based on different principles,...