Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis [0.03%]
癌相关成纤维细胞通过上调脂质生物合成促进ALK驱动的肺腺癌细胞的耐药性
Ann-Kathrin Daum,Lisa Schlicker,Marc A Schneider et al.
Ann-Kathrin Daum et al.
Background: Targeted therapy interventions using tyrosine kinase inhibitors (TKIs) provide encouraging treatment responses in patients with ALK-rearranged lung adenocarcinomas, yet resistance occurs almost inevitably. In ...
Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? [0.03%]
血清代谢标志物能反映健康生活方式与结直肠癌风险之间的关系吗？
Komodo Matta,Vivian Viallon,Anastasia Chrysovalantou Chatziioannou et al.
Komodo Matta et al.
Background: Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomic...
Lamsal Apsana,Andersen Sonja Benedikte,Nonstad Unni et al.
Lamsal Apsana et al.
Background: Despite decades of efforts to find successful treatment approaches, cachexia remains a major unmet medical need. This condition, that affects patients with diverse underlying conditions, is characterized by se...
Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights [0.03%]
富马酸水合酶在乳腺癌中的致癌作用：代谢重组和机制洞察
Shyng-Shiou F Yuan,Anupama Vadhan,Hieu D H Nguyen et al.
Shyng-Shiou F Yuan et al.
Breast cancer remains the most prevalent malignancy among women globally, with its complexity linked to genetic variations and metabolic alterations within tumor cells. This study investigates the role of fumarate hydratase (FH), a key enzy...
Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation [0.03%]
生理培养基对急性髓系白血病生物能量和细胞增殖的影响
Brett R Chrest,McLane M Montgomery,Raphael T Aruleba et al.
Brett R Chrest et al.
Increasing emphasis has been placed on improving the physiological relevance of cell culture media with formulations such as Human Plasma-Like Medium (HPLM). Given that shifts in mitochondrial metabolism and nutrient use are emerging as ant...
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells [0.03%]
改进的VPS4B O-GlcNAc修饰触发脂肪细胞向鼻咽癌细胞转移油滴
Haimeng Yin,Ying Shan,Qin Zhu et al.
Haimeng Yin et al.
Background: The tumor microenvironment (TME) supplies critical metabolites that support cancer cell survival and progression. Adipocytes support tumor progression by secreting free fatty acids (FFAs) and adipokines; howev...
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival [0.03%]
乳酸脱氢酶A偶联的NAD+再生对急性髓系白血病细胞存活至关重要
Ayşegül Erdem,Séléna Kaye,Francesco Caligiore et al.
Ayşegül Erdem et al.
Background: Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent of glycolysis depen...
S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer [0.03%]
腺苷蛋氨酸代谢调控结直肠癌CD8+t细胞功能
Xiaohua Yang,Tianzhang Kou,Hongmiao Wang et al.
Xiaohua Yang et al.
Metabolite nutrients within the tumor microenvironment shape both tumor progression and immune cell functionality. It remains elusive how the metabolic interaction between T cells and tumor cells results in different anti-cancer immunothera...
Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer [0.03%]
卵巢癌和胃肠道癌症患者腹水中微生物来源的代谢产物的鉴定及其影响
Sisi Deng,Wooyong Kim,Kefan Cheng et al.
Sisi Deng et al.
Background: Malignant ascites is a common complication of advanced ovarian cancer (OC) and gastrointestinal cancer (GI), significantly impacting metastasis, quality of life, and survival. Increased intestinal permeability...
Proteomic and lipidomic analysis of low-density lipoprotein identifies potential biomarkers of early estrogen receptor-positive breast cancer [0.03%]
低密度脂蛋白的蛋白质组和脂质组分析鉴定出雌激素受体阳性早期乳腺癌潜在生物标志物
Yamama Abu Mohsen,Rachel Twitto-Greenberg,Anna Cohen et al.
Yamama Abu Mohsen et al.
Estrogen receptor (ER)-positive breast cancer (BC) is a prevalent and fatal cancer among women, and there is a need to identify molecules involved in the disease pathophysiology which could also serve as biomarkers for early detection. Dete...