Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum [0.03%]
Hk2在产后小脑中的来源是颗粒神经元前体细胞
Timothy R Gershon,Andrew J Crowther,Hedi Liu et al.
Timothy R Gershon et al.
Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma [0.03%]
AS160_v2剪接变体的表达和磷酸化支持葡萄糖转运蛋白GLUT4激活及瓦博格效应在多发性骨髓瘤中的作用
Javelin C Cheng,Samuel K McBrayer,Cristian Coarfa et al.
Javelin C Cheng et al.
Background: Multiple myeloma (MM) is a fatal plasma cell malignancy exhibiting enhanced glucose consumption associated with an aerobic glycolytic phenotype (i.e., the Warburg effect). We have previously demonstrated that ...
Pierre Leprince
Pierre Leprince
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells [0.03%]
富马酸水合酶缺乏的癌细胞中反向精氨琥珀酸裂解酶活性增强
Liang Zheng,Elaine D MacKenzie,Saadia A Karim et al.
Liang Zheng et al.
Background: Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell...
Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells [0.03%]
呼吸链复合物I对线粒体缺陷肿瘤细胞产生瓦堡效应的表型是必需的
Claudia Calabrese,Luisa Iommarini,Ivana Kurelac et al.
Claudia Calabrese et al.
Background: Aerobic glycolysis, namely the Warburg effect, is the main hallmark of cancer cells. Mitochondrial respiratory dysfunction has been proposed to be one of the major causes for such glycolytic shift. This hypoth...
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production [0.03%]
p53促进糖异生相关基因的表达并增强肝脏葡萄糖生成作用
Ido Goldstein,Keren Yizhak,Shalom Madar et al.
Ido Goldstein et al.
Background: The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as g...
Calorie restriction and cancer prevention: a mechanistic perspective [0.03%]
从机制上谈卡里restricted和癌症预防的关系
Stephen D Hursting,Sarah M Dunlap,Nikki A Ford et al.
Stephen D Hursting et al.
Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned from research on CR to cancer ...
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism [0.03%]
糖酵解通量的平衡：6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶在癌症代谢中的作用
Susana Ros,Almut Schulze
Susana Ros
The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor suppressors....
Elena Anso,Andrew R Mullen,Dean W Felsher et al.
Elena Anso et al.
Background: Cancer cells engage in aerobic glycolysis and glutaminolysis to fulfill their biosynthetic and energetic demands in part by activating MYC. Previous reports have characterized metabolic changes in proliferatin...
Chi Van Dang,Michael Pollak
Chi Van Dang