Andrew N Macintyre,Jeffrey C Rathmell
Andrew N Macintyre
Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify their metabolism after activation b...
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging [0.03%]
基于纳米结构引发基质辅助激光解析电离成像监测化疗过程中单细胞及肿瘤代谢响应
Peter J O&#x;Brien,Michelle Lee,Mary E Spilker et al.
Peter J O&#x;Brien et al.
Background: Tissue imaging of treatment-induced metabolic changes is useful for optimizing cancer therapies, but commonly used methods require trade-offs between assay sensitivity and spatial resolution. Nanostructure-Ini...
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth [0.03%]
甾醇调节元件结合蛋白依赖性脂质合成对细胞存活和肿瘤生长的支持作用
Beatrice Griffiths,Caroline A Lewis,Karim Bensaad et al.
Beatrice Griffiths et al.
Background: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregul...
Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations [0.03%]
代谢调节因子FGFR4缺乏通过系统和微环境代谢改变延缓乳腺癌进展
Yongde Luo,Chaofeng Yang,Min Ye et al.
Yongde Luo et al.
Background: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnor...
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates [0.03%]
癌细胞的代谢需求与其大小和蛋白质合成速率相关耦合
Sonia C Dolfi,Leo Li-Ying Chan,Jean Qiu et al.
Sonia C Dolfi et al.
Background: Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that t...
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis [0.03%]
利用商业化的基于靶向液相色谱质谱的代谢组学试剂盒探索性研究脑脊液中代谢物以区分脑膜转移癌
Background: Leptomeningeal metastasis (LM) is a devastating complication of cancer that is difficult to treat. Thus, early diagnosis is essential for LM patients. However, cerebrospinal fluid (CSF) cytology has low sensit...