Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism [0.03%]
6-磷酸果糖-2-激酶(PFKFB3)的抑制通过诱导自噬作为生存机制来应对缺氧环境
Alden C Klarer,Julie O&#x;Neal,Yoannis Imbert-Fernandez et al.
Alden C Klarer et al.
Background: Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from f...
Pearl Lee,Karen H Vousden,Eric C Cheung
Pearl Lee
Cancers cells shift their metabolism towards glycolysis in order to help them support the biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and avoid excessive reactive oxygen species (ROS) accumulatio...
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress [0.03%]
酸中毒会重新编程细胞代谢以减轻氧化应激
Gregory Lamonte,Xiaohu Tang,Julia Ling-Yu Chen et al.
Gregory Lamonte et al.
Background: A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microen...
Shawn McGuirk,Simon-Pierre Gravel,Geneviève Deblois et al.
Shawn McGuirk et al.
Background: Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic route in cancer cells. However, little ...
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma [0.03%]
hexokinase-2介导的呼吸型糖酵解在小脑神经发生及髓母细胞瘤病理发生中的作用
Timothy R Gershon,Andrew J Crowther,Andrey Tikunov et al.
Timothy R Gershon et al.
Background: While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma [0.03%]
己糖激酶2介导的神经元糖酵解对小脑神经发生及髓母细胞瘤发病的作用不可或缺
Timothy R Gershon,Andrew J Crowther,Andrey Tikunov et al.
Timothy R Gershon et al.
Background: While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells [0.03%]
喹啉-3-磺胺类衍生物抑制乳酸脱氢酶A并逆转癌细胞的糖酵解作用
Julia Billiard,Jennifer B Dennison,Jacques Briand et al.
Julia Billiard et al.
Background: Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerob...
LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer [0.03%]
LKB1是ErbB2阳性乳腺癌肿瘤发生和促生长代谢的关键调控因子
Fanny Dupuy,Takla Griss,Julianna Blagih et al.
Fanny Dupuy et al.
Background: Germline and somatic mutations in STK11, the gene encoding the serine/threonine kinase LKB1, are strongly associated with tumorigenesis. While loss of LKB1 expression has been linked to breast cancer, the mech...
Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers [0.03%]
ETS-1的基因表达谱揭示了卵巢癌和乳腺癌中的代谢及氧化应激相关性
Meghan L Verschoor,Chris P Verschoor,Gurmit Singh
Meghan L Verschoor
Background: The Ets-1 proto-oncogene is frequently upregulated in cancer cells, with known involvement in cancer angiogenesis, metastasis, and more recently energy metabolism. In this study we have performed various bioin...
Jason A Zastre,Rebecca L Sweet,Bradley S Hanberry et al.
Jason A Zastre et al.
The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication of new daughter cells. To suppo...