Metformin directly acts on mitochondria to alter cellular bioenergetics [0.03%]
二甲双胍通过直接作用于线粒体来改变细胞生物能量学
Sylvia Andrzejewski,Simon-Pierre Gravel,Michael Pollak et al.
Sylvia Andrzejewski et al.
Background: Metformin is widely used in the treatment of diabetes, and there is interest in 'repurposing' the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin r...
GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer [0.03%]
GLUT3在上皮间质转化过程中被诱导并促进非小细胞肺癌细胞增殖
Mark Masin,Jessica Vazquez,Simona Rossi et al.
Mark Masin et al.
Background: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of ...
Edoardo Gaude,Christian Frezza
Edoardo Gaude
Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic aberrations associated with it....
Decoding the dynamics of cellular metabolism and the action of 3-bromopyruvate and 2-deoxyglucose using pulsed stable isotope-resolved metabolomics [0.03%]
应用脉冲稳定的同位素分辨代谢组学解析细胞代谢动力学及溴化丙酮酸和2-脱氧葡萄糖的作用机制
Matthias Pietzke,Christin Zasada,Susann Mudrich et al.
Matthias Pietzke et al.
Background: Cellular metabolism is highly dynamic and continuously adjusts to the physiological program of the cell. The regulation of metabolism appears at all biological levels: (post-) transcriptional, (post-) translat...
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane [0.03%]
代谢供应与需求的分离：膜能量需求波动时的正常生理反应中的有氧糖酵解
Tamir Epstein,Liping Xu,Robert J Gillies et al.
Tamir Epstein et al.
Background: Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is...
Mitochondria and cancer [0.03%]
线粒体与癌症
Navdeep S Chandel
Navdeep S Chandel
Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice [0.03%]
亮氨酸补充剂通过不同机制促进正常体重和超重小鼠的胰腺癌生长
Kristyn A Liu,Laura M Lashinger,Audrey J Rasmussen et al.
Kristyn A Liu et al.
Background: The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses ...
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process [0.03%]
一种通过氧化还原过程攻击肿瘤细胞中α-酮戊二酸脱氢酶的小分子设计及其策略效应
Shawn D Stuart,Alexandra Schauble,Sunita Gupta et al.
Shawn D Stuart et al.
Background: Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growi...
Ralph J Deberardinis
Ralph J Deberardinis
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways [0.03%]
癌症代谢中的低氧信号通路：同时选择相互连接的生理通路的重要性
Norma Masson,Peter J Ratcliffe
Norma Masson
Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pathways that are dysregulated in ...