Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302 [0.03%]
丙酮酸使胰腺肿瘤对HAPTH-302敏感
Jonathan W Wojtkowiak,Heather C Cornnell,Shingo Matsumoto et al.
Jonathan W Wojtkowiak et al.
Background: Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clin...
Christopher S Ahn,Christian M Metallo
Christopher S Ahn
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for th...
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? [0.03%]
如何在癌症和化疗中调节凋亡的线粒体途径
Rana Elkholi,Thibaud T Renault,Madhavika N Serasinghe et al.
Rana Elkholi et al.
In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that promote tumorigenesis and how ...
Aaron M Hosios,Matthew G Vander Heiden
Aaron M Hosios
Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells [0.03%]
代谢和转录谱分析发现丙酮酸脱氢酶激酶4介导肿瘤细胞上皮间质转化和耐药性
Yuting Sun,Anneleen Daemen,Georgia Hatzivassiliou et al.
Yuting Sun et al.
Background: Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug ...
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis [0.03%]
SIRT3和SIRT4是连接线粒体代谢与肿瘤发生的线粒体抑癌蛋白
Yueming Zhu,Yufan Yan,Daniel R Principe et al.
Yueming Zhu et al.
It is a well-established scientific observation that mammalian cells contain fidelity proteins that appear to protect against and adapt to various forms of endogenous and exogenous cellular conditions. Loss of function or genetic mutation o...
Endothelial cell metabolism: parallels and divergences with cancer cell metabolism [0.03%]
内皮细胞代谢：与癌细胞代谢的相同点和不同点
Dries Verdegem,Stijn Moens,Peter Stapor et al.
Dries Verdegem et al.
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to...
Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia [0.03%]
酮体介导的代谢重编减弱胰腺癌恶病质
Surendra K Shukla,Teklab Gebregiworgis,Vinee Purohit et al.
Surendra K Shukla et al.
Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known...
Debarshi Roy,Susmita Mondal,Chen Wang et al.
Debarshi Roy et al.
Background: Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogeni...
Eileen White
Eileen White
Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cellular self-cannibalization by a...